Fragmentation of the rest‐activity rhythm correlates with age‐related cognitive deficits

Oosterman, Joukje M.; Someren, Eus J.W. Van; Vogels, Raymond L.C.; Harten, Barbera van; Scherder, E.J.A.

doi:10.1111/j.1365-2869.2008.00704.x

Cited by 157 publications

(129 citation statements)

References 37 publications

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“…Strong evidence for this stems from the fact that, if sleep and wakefulness occur out of phase with internal biological time, this impairs several cognitive functions such as learning in humans (Wright et al, 2006). Further, fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits (Oosterman et al, 2009). Thus, stable and consolidated circadian sleep-wake rhythms are an essential requirement for proper cognitive functioning in health and disease, and light is only a means to an end.…”

Section: Au3mentioning

confidence: 99%

Can light make us bright? Effects of light on cognition and sleep

Chellappa

Gordijn

Cajochen

2011

Progress in Brain Research

127

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Light elicits robust nonvisual effects on numerous physiological and behavioral variables, such as the human sleep-wake cycle and cognitive performance. Light effects crucially rely on properties such as dose, duration, timing, and wavelength. Recently, the use of methods such as fMRI to assess light effects on nonvisual brain responses has revealed how light can optimize brain function during specific cognitive tasks, especially in tasks of sustained attention. In this chapter, we address two main issues: how light impinges on cognition via consolidation of human sleep-wake cycles; and how light directly impacts on sleep and cognition, in particular, in tasks of sustained attention. A thorough understanding of how light affects sleep and cognitive performance may help to improve light settings at home and at the workplace in order to improve well-being.

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Section: Au3mentioning

confidence: 99%

Can light make us bright? Effects of light on cognition and sleep

Chellappa

Gordijn

Cajochen

2011

Progress in Brain Research

127

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“…Increasing age is associated with a decrease in sleep efficiency [4], early morning awakening [5; 6], nocturnal awakenings [1 ] and increased sleep latency [7]. Poor sleep in older people has been linked to cognitive decline [8], an increase in falls [9] and poorer physical and mental health [10] with a significant correlation between cognitive ratings and sleep fragmentation [11]. Sleep changes may be due to any number of factors including age-related effects on the homeostatic and/or circadian regulation of sleep [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Blue-Enriched Lighting for Older People Living in Care Homes: Effect on Activity, Actigraphic Sleep, Mood and Alertness

Hopkins

Morgan

Schlangen

et al. 2017

CAR

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Environmental (little outdoor light; low indoor lighting) and age-related physiological factors (reduced light transmission through the ocular lens, reduced mobility) contribute to a light-deprived environment for older people living in care homes. This study investigates the effect of increasing indoor light levels with blueenriched white lighting on objective (rest-activity rhythms, performance) and self-reported (mood, sleep, alertness) measures in older people. Eighty residents (69 female), aged 86 ± 8 yrs (mean ± SD), participated (MMSE 19 ± 6). Overhead fluorescent lighting was installed in communal rooms (n=20) of seven care homes.Four weeks of blue-enriched white lighting (17000 K  900 lux) were compared with four weeks of control white lighting (4000 K  200 lux), separated by three weeks wash-out. Participants completed validated mood and sleep questionnaires, psychomotor vigilance task (PVT) and wore activity and light monitors (AWL). Restactivity rhythms were assessed by cosinor, non-parametric circadian rhythm (NPCRA) and actigraphic sleep analysis. Blue-enriched (17000 K) light increased wake time and activity during sleep decreasing actual sleep time, sleep percentage and sleep efficiency (p < 0.05) (actigraphic sleep). Compared to 4000 K lighting, blueenriched 17000 K lighting significantly (p < 0.05) advanced the timing of participants' rest-activity rhythm (cosinor), increased daytime and night-time activity (NPCRA), reduced subjective anxiety (HADA) and sleep quality (PSQI). There was no difference between the two light conditions in daytime alertness and performance (PVT). Blue-enriched lighting produced some positive (increased daytime activity, reduced anxiety) and negative (increased night-time activity, reduced sleep efficiency and quality) effects in older people.Keywords: care home, light therapy; mood; elderly; rest-activity; sleep. 3 Graphical AbstractThe effect of blue-enriched 17000 K lighting (right) on the rest-activity, sleep and mood of older people living in care homes has been investigated compared to control 4000 K lighting (middle) (left, original lighting) 4

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“…Sleep fragmentation 1 is a common symptom in older adults and is associated with a number of adverse health outcomes including falls, 2 poor quality of life, 3 poorer cognition, [4][5][6] and depression. 7 Sleep disorders such as sleep apnea contribute to sleep fragmentation in some older adults.…”

Section: Introductionmentioning

confidence: 99%