Fragmentation of α- and β-alanine molecules by ions at Bragg-peak energies

Bari, Sadia; Sobocinski, P.; Postma, J.; Alvarado, Fresia; Hoekstra, Ronnie; Bernigaud, V.; Manil, B.; Rangama, Jimmy; Huber, B. A.; Schlathölter, Thomas

doi:10.1063/1.2830032

Cited by 41 publications

(37 citation statements)

References 28 publications

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“…The interaction of high energy radiation, electrons, ions and radicals with biomolecules, in particular with the DNA fragments, nucleic purine and pyrimidine bases, phosphate units and deoxyribose sugar, has been extensively studied to uncover effects of primary and secondary particles in radiation damage of living cells and other biological systems [1][2][3][4][5][6]. The secondary electrons, which are produced in large quantities by the primary ionizing particles in the biological material, may cause single-and double strand breaks in the polynucleotides of DNA through site selective cleavage of the molecular bonds.…”

Section: Introductionmentioning

confidence: 99%

Ionization and ionic fragmentation of tetrahydrofuran molecules by electron collisions

Dampc¹,

Szymańska²,

Mielewska³

et al. 2011

J. Phys. B: At. Mol. Opt. Phys.

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Electron impact ionization and ionic fragmentation of tetrahydrofuran molecules in the gas phase were studied in the energy range from ionization threshold up to 150 eV using the technique of mass spectrometry. The cation mass spectra, ionization and ionic fragmentation efficiencies were measured over this energy range. Well-resolved mass peaks were detected in the mass range 10-72 amu and assigned to corresponding ionic molecular fragments. The most abundant cation in the mass spectra is at 42 amu. Appearance energies of selected ionic fragments were also determined. Possible ionic fragmentation processes are discussed.

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Section: Introductionmentioning

confidence: 99%

Ionization and ionic fragmentation of tetrahydrofuran molecules by electron collisions

Dampc¹,

Szymańska²,

Mielewska³

et al. 2011

J. Phys. B: At. Mol. Opt. Phys.

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“…[20] This was achieved through the detection of cationsi n coincidence, ap owerful tool to extract time-related information about fragmentationp rocesses. This technique has been appliedt om ultiply ionized amino acids [21,22] and DNA bases.…”

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confidence: 99%

Formation and Fragmentation of Protonated Molecules after Ionization of Amino Acid and Lactic Acid Clusters by Collision with Ions in the Gas Phase

et al. 2015

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Collisions between O(3+) ions and neutral clusters of amino acids (alanine, valine and glycine) as well as lactic acid are performed in the gas phase, in order to investigate the effect of ionizing radiation on these biologically relevant molecular systems. All monomers and dimers are found to be predominantly protonated, and ab initio quantum-chemical calculations on model systems indicate that for amino acids, this is due to proton transfer within the clusters after ionization. For lactic acid, which has a lower proton affinity than amino acids, a significant non-negligible amount of the radical cation monomer is observed. New fragment-ion channels observed from clusters, as opposed to isolated molecules, are assigned to the statistical dissociation of protonated molecules formed upon ionization of the clusters. These new dissociation channels exhibit strong delayed fragmentation on the microsecond time scale, especially after multiple ionization.

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“…For a-alanine, [7] formation of COOH À or HCOO À (m/z 45) was one of the most dominant channels, whereas for bA it was a rather weak channel. An explanation for this molecule-specific observation may be given by the study reported by Bari et al [1,2] in which CÀC a bond cleavage (leading to the formation of the CH 3 CH(NH 2 )…”

Section: M/z 40 To 45mentioning

confidence: 95%

“…[1,2] Both the intensity and the kinetic energy of the various ionic fragments differ from one isomer to the other.…”

Section: Introductionmentioning

confidence: 99%

Dissociative Electron Attachment to β‐Alanine

et al. 2011

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A detailed study on dissociative electron attachment (DEA) to β-alanine (βA) in the gas phase is presented. Ion yields as a function of the incident electron energy from about 0 to 15 eV have been measured for most of the fragments. As for all α-amino acids, the main reaction corresponds to the loss of a hydrogen atom, although many other fragments have been observed that involved more complex bond cleavages. Threshold energies have been calculated by using the G4(MP2) method for various decomposition reactions. Fragmentation pathways were also investigated to measure metastable decays of the intermediate fragment anion (βA-H)(-) by using the mass-analyzed ion kinetic energy (MIKE) scan technique. Comparisons with α-alanine and other amino acids are made when relevant.

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Fragmentation of α- and β-alanine molecules by ions at Bragg-peak energies

Cited by 41 publications

References 28 publications

Ionization and ionic fragmentation of tetrahydrofuran molecules by electron collisions

Ionization and ionic fragmentation of tetrahydrofuran molecules by electron collisions

Formation and Fragmentation of Protonated Molecules after Ionization of Amino Acid and Lactic Acid Clusters by Collision with Ions in the Gas Phase

Dissociative Electron Attachment to β‐Alanine

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