Fragmented gelsolins are increased in rheumatoid arthritis-associated interstitial lung disease with usual interstitial pneumonia pattern

Suhara, Kozo; Miyazaki, Yasunari; Okamoto, Tsukasa; Ishizuka, Masahiro; Tsuchiya, Kimitake; Inase, Naohiko

doi:10.1016/j.alit.2015.08.002

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…In addition, Landi’s team found that 14-3-3ϵ was increased in the BALF proteome of SSc-ILD patients compared with nonsmokers ( 18 , 20 ). In inflammatory and autoimmune diseases, 14-3-3-ϵ, as a component of the TNFR2 complex, restricts the activation of NF-κB through PI3K/Akt/mTOR signaling and stimulates the activation of C/EBP-β, thus guiding the plasticity of macrophages ( 43 ).…”

Section: Proteomics Studies In Different Ctd-ild Subtypesmentioning

confidence: 99%

Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease

Luo

et al. 2023

Front. Immunol.

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Interstitial lung disease (ILD) is one of the most serious lung complications of connective tissue disease (CTD). The application of proteomics in the past decade has revealed that various proteins are involved in the pathogenesis of each subtype of CTD-ILD through different pathways, providing novel ideas to study pathological mechanisms and clinical biomarkers. On this basis, a multidimensional diagnosis or prediction model is established. This paper reviews the results of proteomic detection of different subtypes of CTD-ILD and discusses the role of some differentially expressed proteins in the development of pulmonary fibrosis and their potential clinical applications.

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Section: Proteomics Studies In Different Ctd-ild Subtypesmentioning

confidence: 99%

Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease

Luo

et al. 2023

Front. Immunol.

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“…Accordingly, BAL with cellular analysis is now formally recommended to assist in the diagnosis of CHP ( 181 ) and has received a conditional recommendation for excluding other potential ILD causes when diagnosing IPF ( 182 ). BAL protein biomarkers may help differentiate ILD subtypes, including organizing pneumonia from UIP in patients with RA-ILD ( 183 ), IPF from other forms of ILD ( 93 , 184 – 186 ), as well as CHP from IPF ( 100 ). Exhaled breath analysis of volatile organic compounds is an evolving, but promising modality for discriminating ILD subtypes that may 1 day provide a non-invasive alternative to BAL ( 187 ).…”

Section: Airway Biomarkersmentioning

confidence: 99%

Biomarkers in Progressive Fibrosing Interstitial Lung Disease: Optimizing Diagnosis, Prognosis, and Treatment Response

2021

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Interstitial lung disease (ILD) comprises a heterogenous group of diffuse lung disorders that commonly result in irreversible pulmonary fibrosis. While idiopathic pulmonary fibrosis (IPF) is the prototypical progressive fibrosing ILD (PF-ILD), a high proportion of patients with other ILD subtypes develop a PF-ILD phenotype. Evidence exists for shared pathobiology leading to progressive fibrosis, suggesting that biomarkers of disease activity may prove informative across the wide spectrum of ILDs. Biomarker investigation to date has identified a number of molecular markers that predict relevant ILD endpoints, including disease presence, prognosis, and/or treatment response. In this review, we provide an overview of potentially informative biomarkers in patients with ILD, including those suggestive of a PF-ILD phenotype. We highlight the recent genomic, transcriptomic, and proteomic investigations that identified these biomarkers and discuss the body compartments in which they are found, including the peripheral blood, airway, and lung parenchyma. Finally, we identify critical gaps in knowledge within the field of ILD biomarker research and propose steps to advance the field toward biomarker implementation.

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“…Nevertheless, the less common organizing pneumonia (OP) and lymphocytic interstitial pneumonia are not as rare as hypothesized. The proteomic profiles of UIP and OP were compared by Suhara et al [38] by analyzing BALf of patients with 2-DE and nano-LC-ESI-MS/MS. The levels of the fragmented proteins gelsolin and Ig kappa chain C region were found to be significantly higher in UIP patients compared to those with an OP pattern.…”

Section: Rheumatoid Arthritis-associated Lung Diseasementioning

confidence: 99%

“…Among others, the authors observed that retinol-binding protein 4 (RBP4) and fetuin-A were significantly lowered in patients with active TB compared to controls, thus suggesting that they could be considered potential biomarkers for monitoring the course of the disease during clinical treatment. [32,[35][36] Lung fibrosis associated to SSc BALf [32,37] RA-ILD BALf [38] PLCH BALf [32,39] CF Serum [41] COPD BALf [29,30,44,46,47] IPAH Serum [48][49][50] TB Serum [61] Electrophoresis -Life Sciences Practical Applications…”

Section: Tuberculosismentioning

confidence: 99%

The Role of One- and Two-Dimensional Electrophoretic Techniques in Proteomics of the Lung

Viglio¹,

Cagnone²,

Chiarelli³

et al. 2018

Electrophoresis - Life Sciences Practical Applications

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The current chapter was designed to keep the reader informed about the present status of pulmonary proteome. Taken together, the results documented here demonstrate that, after a decade of activity, proteomics of pulmonary diseases is catching up with its promise. The constantly growing number of reports in this area supports the view of this approach as one of the decisive methodological tools for the identification/characterization of diseaseassociated proteins. In terms of experimental procedures, the basic options available for proteomic investigations consist in the identification of proteins through the use of gelbased or gel-free techniques followed by MS. Obviously, the question arises of whether sophisticated technologies (such as the non-gel-based proteomic procedures) may currently be more fruitful, in terms of candidate protein marker identification, than "conventional" (read electrokinetic) approaches. In light of the versatility and high degree of reproducibility shown by these new potent strategies, a positive answer is perhaps not surprising. Nevertheless, as documented in this chapter, despite being less sophisticated than competing ones, gel-based techniques still represent a widely used procedure able to generate a reliable protein "fingerprint" and to produce qualitative and quantitative information on the protein patterns of a variety of human fluids.

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Fragmented gelsolins are increased in rheumatoid arthritis-associated interstitial lung disease with usual interstitial pneumonia pattern

Abstract: Fragmented gelsolins may be associated with the pathogenesis of fibrosis in RA-ILD.

Cited by 10 publications

References 33 publications

Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease

Proteomics: Potential techniques for discovering the pathogenesis of connective tissue diseases-interstitial lung disease

Biomarkers in Progressive Fibrosing Interstitial Lung Disease: Optimizing Diagnosis, Prognosis, and Treatment Response

The Role of One- and Two-Dimensional Electrophoretic Techniques in Proteomics of the Lung

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