Frailty: Diagnosis and management

Morley, John E.

doi:10.1007/s12603-011-0338-4

Cited by 79 publications

(31 citation statements)

References 106 publications

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“…Included subjects were aged 70 years or older and presented at least 1 of the 3 following clinical criteria: (1) Memory complaint spontaneously reported to a general practitioner, (2) limitation in one instrumental activity of daily living, (3) slow gait speed. Subjects with dementia were not included in the trial.…”

Section: Methodsmentioning

confidence: 99%

Neuropsychological Profile of “Cognitive Frailty” Subjects in Mapt Study

Delrieu¹,

Andrieu²,

Pahor³

et al. 2016

J Prev Alz Dis

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Objectives: An international group proposed the existence of “cognitive frailty”, a condition defined by simultaneous presence of physical frailty and cognitive impairment in the absence of dementia. The objective was to compare the neuropsychological profiles in subgroups of elders differentiated across their physical frailty (Fried phenotype) and cognitive status (Clinical Dementia Rating score) to characterize the “cognitive frailty” entity. Method: We studied baseline characteristics of 1,617 subjects enrolled in Multidomain Alzheimer Disease Preventive Trial (MAPT). Included subjects were aged 70 years or older and presented at least 1 of the 3 following clinical criteria: (1) Memory complaint spontaneously reported to a general practitioner, (2) limitation in one instrumental activity of daily living, (3) slow gait speed. Subjects with dementia were not included in the trial. Results: “Cognitive frailty individuals” significantly differed from “individuals with cognitive impairment and without physical frailty”, scoring worse at executive, and attention tests. They presented subcortico-frontal cognitive pattern different of Alzheimer Disease. Cognitive performance of subjects with 3 criteria or more of the frailty phenotype are cognitively more impaired than subjects with only one. Discusion: The characterization of “cognitive frailty” must be done in frail subjects to set up specific preventive clinical trials for this population.

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Section: Methodsmentioning

confidence: 99%

Neuropsychological Profile of “Cognitive Frailty” Subjects in Mapt Study

Delrieu¹,

Andrieu²,

Pahor³

et al. 2016

J Prev Alz Dis

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“…Recently, the frailty syndrome, which renders individuals more vulnerable to adverse health outcomes through generally subtle and progressive physical changes, has attracted attention in the medical and scientific communities as well as within the public health departments of numerous countries (3). In fact acting on frailty through effective interventions may change the aging trajectories of many individuals from the possible "pathological aging" pattern to the more personally and economically desirable "successful aging" (4).…”

Section: Introductionmentioning

confidence: 99%

Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group

Kelaiditi

Cesari

Canevelli

et al. 2013

The Journal of nutrition, health and aging

766

550

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Abstract:The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons. In parallel, dementia and cognitive disorders also represent major healthcare and social priorities. Although physical frailty and cognitive impairment have shown to be related in epidemiological studies, their pathophysiological mechanisms have been usually studied separately. An International Consensus Group on "Cognitive Specific aim of this approach was to facilitate the design of future personalized preventive interventions in older persons. Finally, the Group discussed the use of multidomain interventions focused on the physical, nutritional, cognitive and psychological domains for improving the well-being and quality of life in the elderly. The consensus panel proposed the identification of the so-called "cognitive frailty" as an heterogeneous clinical manifestation characterized by the simultaneous presence of both physical frailty and cognitive impairment. In particular, the key factors defining such a condition include: 1) presence of physical frailty and cognitive impairment (CDR=0.5); and 2) exclusion of concurrent AD dementia or other dementias. Under different circumstances, cognitive frailty may represent a precursor of neurodegenerative processes. A potential for reversibility may also characterize this entity. A psychological component of the condition is evident and concurs at increasing the vulnerability of the individual to stressors.

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“…Indeed, diabetes mellitus and insulin resistance increase the risk for accelerated aging and for the development of frailty syndrome (Kahn 2007;Sinclair et al 2012;Volpato et al 2012). In addition, the frailty prevalence in elderly with diabetes is much greater than that in the general elderly population, and the frail diabetic individuals have a higher mortality than robust diabetic individuals (Morley 2011;Morley et al 2014;Rodríguez-Mañas et al 2014). Diabetes mellitus disease process may contribute to the increased risk of falls, institutionalization, and disability (Abdelhafiz and Sinclair, 2011).…”

Section: Introductionmentioning

confidence: 99%

Exercise interventions in polypathological aging patients that coexist with diabetes mellitus: improving functional status and quality of life

Cadore

Izquierdo

2015

AGE

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In elderly populations, diabetes is associated with reduced muscle strength, poor muscle quality, and accelerated loss of muscle mass. In addition, diabetes mellitus increases risk for accelerated aging and for the development of frailty syndrome. This disease is also associated with a polypathological condition, and its complications progressively affect quality of life and survival. Exercise interventions, including resistance training, represent the cornerstones of diabetes management, especially in patients at severe functional decline. This review manuscript aimed to describe the beneficial effects of different exercise interventions on the functional capacity of elderly diabetics, including those at polypathological condition. The SciELO, Science Citation Index, MEDLINE, Scopus, SPORTDiscus, and ScienceDirect databases were searched from 1980 to 2015 for articles published from original scientific investigations. In addition to the beneficial effects of exercise interventions on glycemic control, and on the cardiovascular risk factors associated with diabetes, physical exercise is an effective intervention to improve muscle strength, power output, and aerobic power and functional capacity in elderly diabetic patients. Thus, a combination of resistance and endurance training is the most effective exercise intervention to promote overall physical fitness in these patients. In addition, in diabetic patients with frailty and severe functional decline, a multicomponent exercise program including strength and power training, balance exercises, and gait retraining may be an effective intervention to reduce falls and improve functional capacity and quality of life in these patients.

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Frailty: Diagnosis and management

Cited by 79 publications

References 106 publications

Neuropsychological Profile of “Cognitive Frailty” Subjects in Mapt Study

Neuropsychological Profile of “Cognitive Frailty” Subjects in Mapt Study

Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group

Exercise interventions in polypathological aging patients that coexist with diabetes mellitus: improving functional status and quality of life

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