Frailty increases the risk of 30-day mortality, morbidity, and failure to rescue after elective abdominal aortic aneurysm repair independent of age and comorbidities

Arya, Shipra; Kim, Sung In; Duwayri, Yazan; Brewster, Luke P.; Veeraswamy, Ravi K.; Salam, Atef A.; Dodson, Thomas F.

doi:10.1016/j.jvs.2014.08.115

Cited by 218 publications

(166 citation statements)

References 31 publications

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“…Frailty itself has been shown to be a risk factor for death after surgery, even independent of age. 23,24 Although the VQI data set does not have a measure of frailty directly, octogenarian patients were significantly more dependent in their ambulatory status and living situation than the younger population.…”

Section: Discussionmentioning

confidence: 99%

Abdominal aortic aneurysm repair in octogenarians is associated with higher mortality compared with nonoctogenarians

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Arhuidese

et al. 2016

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 99%

Abdominal aortic aneurysm repair in octogenarians is associated with higher mortality compared with nonoctogenarians

Hicks

Obeid

Arhuidese

et al. 2016

Journal of Vascular Surgery

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“…Frailty has been found to be a more powerful predictor of functional status in the elderly than chronological age or comorbidity, with increases in an individual's frailty greatly increasing the risk of death [10,11]. Frailty is also applicable in the diminished homeostatic reserve seen in chronic illness and organ failure.…”

Section: Frailtymentioning

confidence: 99%

The Importance of Prehabilitation in Liver Transplantation

2015

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Over 15,000 patients are listed for liver transplantation across the USA while only 6500 transplants are performed each year. Given the realities of this profound organ shortage, optimal patient preparation is important to assure good outcomes. In recent years, frailty and sarcopenia have emerged as important predictors of post-transplant mortality. Potentially, these risk factors may be remediable with preoperative preparation. Efforts to improve disease management and physical conditioning could not only optimize patients for liver transplantation but could also improve outcomes among those who do not undergo transplantation.

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“…1,2 However, to date, there are no data available on patients treated with endovascular aneurysm repair (EVAR) who have sarcopenia. The purpose of this study was to provide an estimate of long-term mortality risk for EVAR patients with and without sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

Impact of sarcopenia on long-term mortality following endovascular aneurysm repair

et al. 2016

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Sarcopenia, also known as a reduction of skeletal muscle mass, is a patient-specific risk factor for vascular and cancer patients. However, there are no data on abdominal aortic aneurysm (AAA) patients treated with endovascular aneurysm repair (EVAR) who have sarcopenia. To determine the impact of sarcopenia on mortality following EVAR, we retrospectively reviewed 200 patients treated with EVAR by estimating muscle mass on abdominal computed tomography (CT) scans. Mortality was analyzed according to its presence (n=25) or absence (n=175). Sarcopenia was more common in women than men (32.0% vs 9.7%; p=0.005). Patients with sarcopenia had an increased risk of mortality compared to those without (76% vs 48%; p=0.016). Of note, the overall mortality rate was 51% with a median follow up of 8.4 years (interquartile range, 5.3-11.7). In conclusion, the presence of sarcopenia on a CT scan is an important predictor of longterm mortality in patients treated for AAA with EVAR. Pending further study, these data suggest that sarcopenia may aid in pre-procedural long-term survival assessment of patients undergoing EVAR.

show abstract

Frailty increases the risk of 30-day mortality, morbidity, and failure to rescue after elective abdominal aortic aneurysm repair independent of age and comorbidities

Cited by 218 publications

References 31 publications

Abdominal aortic aneurysm repair in octogenarians is associated with higher mortality compared with nonoctogenarians

Abdominal aortic aneurysm repair in octogenarians is associated with higher mortality compared with nonoctogenarians

The Importance of Prehabilitation in Liver Transplantation

Impact of sarcopenia on long-term mortality following endovascular aneurysm repair

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