Frailty index to predict all-cause mortality in Thai community-dwelling older population: A result from a National Health Examination Survey cohort

Srinonprasert, Varalak; Chalermsri, Chalobol; Aekplakorn, Wichai

doi:10.1016/j.archger.2018.05.002

Cited by 18 publications

(22 citation statements)

References 26 publications

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“…The present study also identified a very similar prevalence rate to previously reported in two provinces of northern Thailand, which was a 15.0% frailty prevalence [10]. In addition, a previous study reported that the frailty prevalence in community-dwelling older persons in all parts of Thailand was 22.1%, which was higher than in our study [9]. Interestingly, the prevalence rates of frailty among these Asian countries reflect the level of socioeconomic development of the nations.…”

Section: Discussionsupporting

confidence: 90%

“…Again, geographical, socio-demographic and measurement methods explained the difference in prevalence rates in these two Thai studies. The first study, which was a nationwide follow up of 9208 people aged 60 years or over between 2009-2016 and employed the Thai Frailty Index, reported a rate of 22.1% [9]. The index was based on broad frailty phenotypes, namely, medical comorbidity, functional status, and physical and emotional health.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A Cross-Sectional Study

Thinuan

Siviroj

Lerttrakarnnon

et al. 2020

IJERPH

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This study aimed to determine the prevalence and associated factors of frailty among Thai older persons. A cross-sectional study was conducted with a representative sample of 1806 older persons aged 60 years or older. Frailty was assessed by Fried’s frailty phenotypes, which consists of five criteria, namely, unintended weight loss, exhaustion, slow walking, weak handgrip and decreased physical activity. Older people who met 3 in 5, 1–2 in 5, and none of the criteria were considered frail, pre-frail and non-frail respectively. The prevalence was calculated and multinomial logistic regression was performed. Prevalence rates of frailty, pre-frailty and non-frailty were 13.9% (95% CI 9.9 to 18.8), 50.9% (95% CI 47.5 to 54.1) and 35.1% (95% CI 31.5 to 39.9), respectively. Increasing age, lower education, having no spouse, poorer health perception, increasing number of comorbidities, osteoarthritis and smaller mid-arm circumference increased the risk of frailty (p < 0.001). The prevalence of geriatric frailty syndrome in this study was much higher than that of developed countries but was lower than that of less developed countries. Factors associated with frailty reflect common characteristics of disadvantaged older persons in Thailand.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A Cross-Sectional Study

Thinuan

Siviroj

Lerttrakarnnon

et al. 2020

IJERPH

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“…Thailand (74)(75)(76)(77)(78)(79)(80). The findings of these individual studies were consistent with the findings of this systematic review and would not change the conclusions presented in this Thesis chapter.…”

Section: Literature Updatesupporting

confidence: 86%

Sex differences in frailty: the Frailty Index and the male-female health-survival paradox

Gordon¹

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This publication is a 'highly cited paper' (with 62 citations to date) and is placed in the top 1% of papers in the field of Clinical Medicine in 2017 (Scopus 2019). This manuscript is incorporated into Chapter 2.. Author Contribution E Gordon (candidate) Systematic review and data collection (100%) Data analysis (25%) Data interpretation (100%) Wrote and edited manuscript (80%) Response to reviewers' comments (100%) N Peel Edited manuscript (5%) M Samanta Data analysis (75%) O Theou

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“…Gender has been identified as another influencing factor for the prevalence of frailty, wherein it was found to be higher among women than men according to an African American cohort study involving 5317 men and women aged 65 years and older (14.4% and 7.4%, respectively) [10,19]. Currently, the prevalence of frailty among the aging population of Thailand using the frailty index revealed a high prevalence of frailty (22.1%) and could be used to predict mortality (with a hazard ratio of 2.34 with 95% CI 2.10–2.61) [20]. However, there still has not been any study involving an assessment of the frailty status using both frailty phenotypes and biomarkers among Thailand’s population, especially in the region where the highest proportion of the aging population has been identified [1].…”

Section: Introductionmentioning

confidence: 99%

The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand

Semmarath

Seesen

Yodkeeree

et al. 2019

IJERPH

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Thailand has officially reached the status of an “aged society” and become the developing country with the 2nd largest proportion of senior citizens in Southeast Asia. A cross-sectional study of 526 early-old community dwellers was conducted for the Fried frailty phenotype assessment, This included five indicators: Weakness, slowness, physical activity, exhaustion, and weight loss. C-reactive protein (CRP), interleukin-6 (IL-6), insulin-like growth factor-1, and CD4+:CD8+ Ratio which serve as blood-based biomarkers of frailty. The prevalence of frailty and pre-frail in this population was found to be 15% and 69.6% respectively and was higher among women than men. Frail (n = 58) and non-frail (n = 60) participants were evaluated for the associations between the frail indicators and the blood-based biomarkers. Serum levels of IL-6 and CRP from frail group were significantly elevated when compared with the non-frail counterparts (p = 0.044 and 0.033, respectively), and were significantly associated with the frailty status with an Odd RatioIL-6 [OR] of 1.554-fold (95% confidence interval [CI], 1.229–1.966) and an ORCRP of 1.011-fold (95 CI, 1.006–1.016). Decreased hand-grip strength was the only frailty indicator that was significantly associated with both inflammatory biomarkers, (ORIL-6 of 1.470-fold and ORCRP of 1.008-fold). Our study is the first to assess the frailty status among the early-old population in Thailand. These findings will encourage general practitioners to combine frailty indicators and serum biomarkers as early detection tools for at-risk older adults to achieve the goal of healthy aging.

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Frailty index to predict all-cause mortality in Thai community-dwelling older population: A result from a National Health Examination Survey cohort

Cited by 18 publications

References 26 publications

Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A Cross-Sectional Study

Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A Cross-Sectional Study

Sex differences in frailty: the Frailty Index and the male-female health-survival paradox

The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand

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