Frailty Severity and Cognitive Impairment Associated with Dietary Diversity in Older Adults in Taiwan

Huang, Wei-Ching; Huang, Yi-Chen; Lee, Meei-Shyuan; Chang, Hsing-Yi; Doong, Jia-Yau

doi:10.3390/nu13020418

Cited by 30 publications

(29 citation statements)

References 32 publications

(45 reference statements)

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“…Regarding the CF syndrome, the prevalence of CF syndrome was 4.5% among the study participants. This finding was consistent with several studies around the world; these studies included Roppolo, Mulasso [ 29 ], Ma, Zhang [ 30 ], Panza, Lozupone [ 31 ], Arai, Satake [ 32 ], Liu, Han [ 33 ], Lee, Kim [ 34 ], Aliberti, Cenzer [ 35 ], Moon, Huh [ 36 , 37 ], and two recent studies conducted by Jing, Li [ 38 ] and Navarro-Pardo, Facal [ 39 ].…”

Section: Discussionsupporting

confidence: 91%

Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia

Alkhodary

Aljunid

Ismail

et al. 2022

IJERPH

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Background: Cognitive frailty (CF) as a potential risk factor for dementia, functional disability, poor quality of life, and mortality. The aim of this study was to explore the health care-related utilization and out-of-pocket (OOP) expenditures, sociodemographic characteristics, and comorbidities among elderly Malaysians with CF. Methods: A cross-sectional study targeting elderly Malaysian aged ≥65 years was conducted. The study included all participants of the fourth phase of the Malaysian representative Long-Term-Research-Grant-Scheme Towards-Useful-Aging (LRGS-TUA) community-based study. A structured and validated interview questionnaire was used. Results: In total, 1006 elderly were interviewed, with a 66.18% response rate. Only 730 respondents met the inclusion criteria. Of the eligible respondents, the CF prevalence was 4.5%. Around 60.6% of the participants with CF had utilized outpatient care at government clinics within the past 6 months. The estimated mean total OOP payments for CF during the past 6 months was 84 Malaysian Ringgit (RM) (SD 96.0). Conclusions: CF among elderly Malaysians is within the internationally recognized range of prevalence. The OOP payments for seeking health care among CF elderly are not different from that of other elderly categories. There is a high possibility of underutilization of the health care services of CF cases while they are still needy.

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Section: Discussionsupporting

confidence: 91%

Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia

Alkhodary

Aljunid

Ismail

et al. 2022

IJERPH

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“…Adequate total protein intake (≥1.2 g/kg body weight) from food sources has been identified among the dietary determinants in frailty prevention [23]. In contrast to other studies, intake of protein-rich foods does not show relevance to frailty in our study [24,25]. A possible explanation is that about one-third of our participants were recruited from retirement homes and the rest from community congregate meal sites.…”

Section: Discussioncontrasting

confidence: 72%

Novel Healthy Eating Index to Examine Daily Food Guides Adherence and Frailty in Older Taiwanese

et al. 2021

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This study was conducted to investigate the adherence of Daily Food Guides (DFGs) among older Taiwanese, and the relationship of dietary quality and frailty. 154 functional independent older adults who were retirement home residents or community dwellers involved in congregate meal services were recruited. DFGs adherence was measured using a novel Taiwanese Healthy Index (T-HEI). Dietary quality was further assessed using Dietary Approach to Stop Hypertension (DASH) and Mediterranean Diet Score (MDS). Frailty was defined using modified Fried’s criteria. Of the total participants, 12.3% were considered non-frail individuals, while 77.3% were prefrail, and 10.4% were frail. Compared to non-frail participants, prefrail and frail individuals indicated significantly lower adherence to DFGs (ptrend = 0.025). Intake of dark or orange vegetables (ptrend = 0.010), whole grains (ptrend = 0.007), as well as nuts and seeds (ptrend = 0.029) by non-frail individuals were significantly higher than the levels by prefrail and frail individuals. Linear regression model adjusted for age, gender, and functional ability showed that T-HEI was inversely associated with frailty status (β = −0.16 ± 0, p = 0.047), but additional adjustment for nutritional status attenuated the association (β = −0.14 ± 0, p = 0.103). A similar relationship was observed for DASH but not MDS (DASH: β = −0.18 ± 0.01, p = 0.024; MDS: β = −0.06 ± 0.02, p = 0.465). After adjustment for confounders, the association was not observed. However, the distribution of whole grains component in both DASH and MDS was significantly higher in non-frail than prefrail and frail individuals, indicating the importance of whole grains intake in frailty prevention. In conclusion, higher adherence to DFGs and better dietary quality were associated with a lower prevalence of frailty. Higher nutrient-dense foods intake such as whole grains, dark or orange vegetables, nuts, and seeds mark a watershed in frailty prevention.

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“…On the other hand, another positive effect of caffeine, such as on cognitive functions, does not translate into an unequivocal benefit from habitual intake in older people ( 44 , 45 ), probably because of the well-known tolerance effect that reduces the systemic impact of caffeine ( 46 ). Ultimately, no studies have analyzed the independent influence of coffee/tea consumption on frailty, but only “patterns” in which tea and coffee are components that contribute to the pattern score ( 47–49 ). Therefore, our results on coffee/tea consumption need to be interpreted within older people where, however, further research data are needed.…”

Section: Discussionmentioning

confidence: 99%

Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit–Vegetable Intake

Brunelli

Davin

Sestito

et al. 2021

The Journals of Gerontology: Series A

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Frailty syndrome is an age-related condition involving a loss of resilience, susceptibility to adverse health outcomes, and poor quality of life. This study was conducted in the framework of InveCe.Ab, an ongoing longitudinal population-based study. Plasma from 130 older individuals (older adults aged 76–78 years) was analyzed and validated (on 303 participants) using mass spectrometry-based metabolomics approaches. Equivalence tests showed that metabolites from the central cellular metabolic pathways were equivalent in frail and fit participants. Hippuric acid was the only cometabolite that distinguished fit from frail older adults. Logistic regression analysis indicated that high hippuric acid levels are significantly associated with a reduction of the risk of frailty after 4 years. Mediation analysis using a Frailty Index, hippuric acid, and fruit–vegetable intake supported the role of fruit–vegetable consumption in the hippuric acid relationship with the Frailty Index. These data point to low plasma hippuric acid as a plausible hallmark of frailty status, associated with lower fruit–vegetable intakes.

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Frailty Severity and Cognitive Impairment Associated with Dietary Diversity in Older Adults in Taiwan

Cited by 30 publications

References 32 publications

Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia

Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia

Novel Healthy Eating Index to Examine Daily Food Guides Adherence and Frailty in Older Taiwanese

Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit–Vegetable Intake

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