FRAKSI EKSTRAK ETANOL BUAH PARE (Mommordica charantia L.) SEBAGAI ANTIINFLAMASI TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α)

Abstract

Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.

Potensi Ekstrak Etanol Kulit Batang Jabon (Anthocephalus cadamba (Roxb) Miq.) Sebagai Antiinflamasi

“…Pada penelitian lain pada ekstrak metanol kulit batang jabon didapati bahwa aktivitas antiinflamasi dari ekstrak tersebut kemungkinan adalah melalui penghambatan pelepasan mediator nyeri dan biosintesis prostaglandin (Chandrashekar et al, 2010). Senyawa triterpenoid dapat mengurangi inflamasi pada kaki tikus karena dapat menghambat produksi TNF-(tumour necrosis factor) yang merupakan sitokin proinflamasi (Parawansah et al, 2022). Selain itu juga triterpenoid dapat menghambat ekspresi enzim COX-2 (Wardani, 2020).…”

Oral Administration of Perilla (Perilla frutescens) Leaves Extract Inhibited the Increase of Tumor Necrosis Factor-Alpha, Interleukin-6 and Did Not Inhibit the Increase of Foam Cell Amount in Obese Wistar Rats (Rattus norvegicus)

“…One type of vegetable that is believed to have anti-inflammatory and antioxidant benefits is perilla leaves which contains many terpenoid compounds. Terpenoids are able to suppress the activation of pro-inflammatory cytokines (Parawansah et al, 2022). Another content that is mostly found in perilla leaves is phenolic compounds, which show potential as antioxidants.…”