This paper proposes a cross-layer approach called routing-aware multiple description coding with multipath transport to support video communications over mobile ad-hoc networks. This approach establishes a packet loss model based on the MAC access mechanism and network parameters, and utilizes it along with the routing messages from multipath routing to estimate the packet loss probability of transmitted video packets. Then the estimated results are passed to the application layer to assist reference frame selection for multiple description coding in order to mitigate error propagation introduced in the motioncompensated loop. Results show that this is an effective approach to improve error resilience of video transmission over mobile ad-hoc networks and enhance the video experience for multiple users.