Framework and guide for intralesional steroid injections in idiopathic granulomatous mastitis

Moldoveanu, Dan; Lee, Christine; Hesley, Gina

doi:10.1016/j.ejrad.2023.111118

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…MRI specifically shows peripherally enhancing fluid or solid masses (Figure 6) (12). Current treatment focuses on observation, application of antibiotics, steroids, immunosuppressants, surgery (13)(14)(15)(16), and traditional Chinese The skin of the right breast breakdown forms sinus tracts and ulcerated surfaces. Ultrasound image of a patient with GLM with hypoechoic areas leading to the skin and sinus tract formation.…”

Section: Introductionmentioning

confidence: 99%

Pathological manifestations of granulomatous lobular mastitis

Cui,

Sun,

Guo

et al. 2024

Front. Med.

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Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease with unknown etiology, characterized by non-caseous granulomatous inflammation of the lobules, which infiltrate lymphocytes, neutrophils, plasma cells, monocytes, and eosinophils may accompany. GLM is often misdiagnosed as breast cancer due to the lack of specificity in clinical and imaging examinations, and therefore histopathology is the main basis for confirming the diagnosis. This review provides an overview of the pathological features of granulomatous lobular mastitis and cystic neutrophil granulomatous mastitis (CNGM, a pathologic subtype of GLM). As well as pathologic manifestations of other breast diseases that need to be differentiated from granulomatous lobular mastitis such as breast tuberculosis, lymphocytic mastopathy/diabetic mastopathy, IgG4-related sclerosing mastitis (IgG4-RSM), nodular disease, Wegener’s granulomatosis, and plasma cell mastitis. Besides, discusses GLM and CNGM, GLM and breast cancer, emphasizing that their relationship deserves further in-depth exploration. The pathogenesis of GLM has not yet been clearly articulated and needs to be further explored, pathology enables direct observation of the microscopic manifestations of the disease and contributes to further investigation of the pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Pathological manifestations of granulomatous lobular mastitis

Cui,

Sun,

Guo

et al. 2024

Front. Med.

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Ductal lavage followed by observation versus oral corticosteroids in idiopathic granulomatous mastitis: A randomized trial

Chen,

Huang,

Huang

et al. 2024

Nat Commun

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Oral corticosteroids represents the most prevalent treatment for idiopathic granulomatous mastitis. Ductal lavage with triamcinolone acetonide and antibiotics followed by observation (DL-OBS) has emerged as a novel strategy, but a comparison of them remains lacking. Here in this multicenter, open-label, non-inferiority, randomized trial (ClinicalTrials.gov identifier: NCT03724903), we assigned 140 patients to oral corticosteroids (N = 71) and DL-OBS (N = 69), stratified by baseline M-score. The primary outcome is complete Clinical Response rate at 1 year. The non-inferiority margin is −15%. The primary outcome is 85.5% in DL-OBS and 87.3% in oral corticosteroids (difference: −1.8%; 95%CI, 13.2 to 9.5; P non-inferiority = .01) in intention-to-treat population, and 92.6% vs 98.2% (difference −5.6%; 95%CI −13.4 to 2.2; P non-inferiority = .01) in per-protocol population, respectively. The most common (>15%) adverse events were Cushingoid, epigastric pain and arthralgia in oral corticosteroids, and irregular menstruation in DL-OBS, respectively. Here, we report that DL-OBS shows similar efficacy to oral corticosteroids but with better safety profile.

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Framework and guide for intralesional steroid injections in idiopathic granulomatous mastitis

Cited by 2 publications

References 20 publications

Pathological manifestations of granulomatous lobular mastitis

Pathological manifestations of granulomatous lobular mastitis

Ductal lavage followed by observation versus oral corticosteroids in idiopathic granulomatous mastitis: A randomized trial

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