Framework nucleic acids as promising reactive oxygen species scavengers for anti-inflammatory therapy

Zhu, Yujie; Shi, Ruijianghan; Lu, Weitong; Shi, Sirong; Chen, Yang

doi:10.1039/d3nr05844a

Nanoscale

2024

DOI: 10.1039/d3nr05844a

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Framework nucleic acids as promising reactive oxygen species scavengers for anti-inflammatory therapy

Yujie Zhu,

Ruijianghan Shi,

Weitong Lu

et al.

Abstract: Reactive oxygen species (ROS) are an array of derivatives of molecular oxygen that participate in multiple physiological processes under the control of redox homeostasis. However, in pathological conditions, the over-production...

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Cited by 4 publications

References 109 publications

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Highly Efficient Quenching of Singlet Oxygen by DNA Origami Nanostructures

Andres Garcia‐Diosa,

Grundmeier,

Keller

2024

Chemistry A European J

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DNA origami nanostructures (DONs) are able to scavenge reactive oxygen species (ROS) and their scavenging efficiency toward ROS radicals was shown to be comparable to that of genomic DNA. Herein, we demonstrate that DONs are highly efficient singlet oxygen quenchers outperforming double‐stranded (ds) DNA by several orders of magnitude. To this end, a ROS mixture rich in singlet oxygen is generated by light irradiation of the photosensitizer methylene blue and its cytotoxic effect on Escherichia coli cells is quantified in the presence and absence of DONs. DONs are found to be vastly superior to dsDNA in protecting the bacteria from ROS‐induced damage and even surpass established ROS scavengers. At a concentration of 15 nM, DONs are about 50 000 times more efficient ROS scavengers than dsDNA at an equivalent concentration. This is attributed to the dominant role of singlet oxygen, which has a long diffusion length and reacts specifically with guanine. The dense packing of the available guanines into the small volume of the DON increases the overall quenching probability compared to a linear dsDNA with the same number of base pairs. DONs thus have great potential to alleviate oxidative stress caused by singlet oxygen in diverse therapeutic settings.

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Highly Efficient Quenching of Singlet Oxygen by DNA Origami Nanostructures

Andres Garcia‐Diosa,

Grundmeier,

Keller

2024

Chemistry A European J

View full text Add to dashboard Cite

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Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations

Fan,

Sun,

Chao

2024

Small Methods

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Tetrahedral framework nucleic acids (tFNAs) are renowned for their controllable self‐assembly, exceptional programmability, and excellent biocompatibility, which have led to their widespread application in the biomedical field. Beyond these features, tFNAs demonstrate unique chemical and biological properties including high cellular uptake efficiency, structural bio‐stability, and tissue permeability, which are derived from their distinctive 3D structure. To date, an extensive range of tFNA‐based nanostructures are intelligently designed and developed for various biomedical applications such as drug delivery, gene therapy, biosensing, and tissue engineering, among other emerging fields. In addition to their role in drug delivery systems, tFNAs also possess intrinsic properties that render them highly effective as therapeutic agents in the treatment of complex diseases, including arthritis, neurodegenerative disorders, and cardiovascular diseases. This dual functionality significantly enhances the utility of tFNAs in biomedical research, presenting valuable opportunities for the development of next‐generation medical technologies across diverse therapeutic and diagnostic platforms. Consequently, this review comprehensively introduces the latest advancements of tFNAs in the biomedical field, with a focus on their benefits and applications as drug delivery nanoplatforms, and their inherent capabilities as therapeutic agents. Furthermore, the current limitations, challenges, and future perspectives of tFNAs are explored.

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Compensatory effect-based oxidative stress management microneedle for psoriasis treatment

Wu,

Yang,

Yang

et al. 2025

Bioactive Materials

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Framework nucleic acids as promising reactive oxygen species scavengers for anti-inflammatory therapy

Abstract: Reactive oxygen species (ROS) are an array of derivatives of molecular oxygen that participate in multiple physiological processes under the control of redox homeostasis. However, in pathological conditions, the over-production...

Cited by 4 publications

References 109 publications

Highly Efficient Quenching of Singlet Oxygen by DNA Origami Nanostructures

Highly Efficient Quenching of Singlet Oxygen by DNA Origami Nanostructures

Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations

Compensatory effect-based oxidative stress management microneedle for psoriasis treatment

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