Framework nucleic acids directed assembly of Au nanostructures for biomedical applications

Abstract

Au nanostructures have elicited considerable interest because of their unique optical and physicochemical properties. These characteristics are mostly depended on the size, shape, chemical composition and dielectric environment of Au nanoparticles (AuNPs). Because of the easy chemical modification and programmable design of DNA molecules, they can not only combine to the surface of AuNP for improved stability, but also form the framework nucleic acids (FNAs) for direct assembly of different Au nanostructures with precise configuration and multiple dimensions. This paper starts with the synthesis and properties of Au nanomaterials. Followed by a brief introduction to the development of FNA nanotechnology, the FNA-directed assembly of Au nanostructures is discussed. Then, we focus on the biomedical applications of these Au nanostructures, including biosensing and therapeutics. In the end, we envision an insight into the remaining challenges and future perspectives toward FNA-based metal functional materials.

Nucleic acid drug and delivery techniques for disease therapy: Present situation and future prospect

“…Research and development in the field of small nucleic acid drugs mainly focus on two directions, one the one hand, the development of gene sequencing technology and the reduction of the cost make it possible for the industrialization of small nucleic acid drugs, 48 on the other hand, the development of RNA modification technology 49 and breakthrough on drug delivery system increases the RNA stability in blood and efficacy and safety. 50,51 The indications for small nucleic acid drugs cover a wide range.…”

Bottom‐up DNA nanostructure‐based paper as point‐of‐care diagnostic: From method to device

“…The conjugation of different FNAs, including linear DNA, aptamers, triplexes and DNAzymes, with different nanomaterials, such as metal nanomaterials, carbon nanotubes and bio-nanomaterials, results in the generation of composite nanomaterials, such as aptamer-AuNP, 115 linear DNA-carbon nanotubes 116 and hairpin DNA functionalized Fe 3 O 4 magnetic nanoparticles. 117 These composite nanomaterials exhibit unique or enhanced functional properties due to the synergistic activity of the two components.…”

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

“…Inorganic nanoparticles include metal, metal oxide, and magnetic nanoparticles. Metal nanoparticles (MNPs) such as gold (Au), silver (Ag), platinum (Pt), palladium (Pd), and quantum dots (QDs), e.g., cadmium selenide (CdSe), cadmium sulfide (CdS), silver sulfide (Ag 2 S), and zinc sulfide (ZnS), , were used. Metal oxide nanoparticles (MO X NPs) such as titanium oxide (TiO 2 ), zinc oxide (ZnO), silicon oxide (SiO 2 ), and hydroxyapatite were used.…”