Framework to leverage physical therapists for the assessment and treatment of chemotherapy-induced peripheral neurotoxicity (CIPN)

Stoller, Stefanie; Capozza, Scott; Alberti, Paola; Lustberg, Maryam B.; Kleckner, Ian R.

doi:10.1007/s00520-023-07734-2

Cited by 8 publications

(6 citation statements)

References 97 publications

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“…From a practical perspective, the role of physical therapy in people with a glioblastoma can be categorized into two main complementary approaches: (1) managing primary and secondary neurological symptoms, such as gait and balance impairments [54], through tailored programs of gait, balance, and lower extremity strengthening exercises [55]; (2) maximizing physiological function and resistance to stressors through moderate to vigorous regimens of multicomponent exercise training [48,50]. Importantly, maximizing physiological function would be fundamental at the pre-habilitation stages, namely before undergoing surgical interventions or chemoradiotherapy.…”

Section: Physical Therapy Rehabilitationmentioning

confidence: 99%

Rehabilitation in People Living with Glioblastoma: A Narrative Review of the Literature

Zanotto,

Glover,

Zanotto

et al. 2024

Cancers

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Glioblastoma is the most common primary malignant brain tumor. While preliminary data point to the positive effects of rehabilitation for patients with glioblastoma, there are unique challenges for clinicians working with this population, including limited life expectancy and/or rapid neurological deterioration. The aim of this article is to review the literature on rehabilitation of adults with glioblastoma, including the feasibility of interventions, their effectiveness, as well as the current clinical practice. The reviewed literature suggests that rehabilitation has been found beneficial for improving the functional prognosis and quality of life of adults with glioblastoma and is desired by patients. We summarize the qualitative evidence regarding healthcare professionals’ and patients’ perspectives on the use of supportive care services. We conclude there is a need for the design of effective rehabilitation programs for patients with glioblastoma, as well as for the development of glioblastoma-specific clinical guidelines for rehabilitation practitioners.

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Section: Physical Therapy Rehabilitationmentioning

confidence: 99%

Rehabilitation in People Living with Glioblastoma: A Narrative Review of the Literature

Zanotto,

Glover,

Zanotto

et al. 2024

Cancers

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“…Yet, some chemotherapy agents such as taxanes, frequently used in breast cancer, and platins might have extremely harmful neurotoxic adverse effects that can harm neuronal structures via glial damage, inflammation, mitochondrial dysfunction, and other mechanisms [ 1 , 2 ]. Chemotherapy-induced peripheral neuropathy (CIPN), which usually emerges as sensory impairments and ultimately reduces functional ability and quality of life in cancer survivors, is known as a side effect of the specific chemotherapy agents [ 3 ]. The potential mechanism of Taxanes on CIPN was reported to be characterized by failure to achieve anaphase due to the stabilizing effect of these drugs on tubulin proteins.…”

Section: Introductionmentioning

confidence: 99%

“…Not only patients, but also healthcare professionals who work in oncology report the importance of detecting, managing, and monitoring CIPN, however, there is a lack of knowledge about the available assessment methods [ 15 ]. In addition, there is generally not much time to be informed about the management of CIPN in busy oncology clinical settings, and therefore patients might suffer from how to cope with mild to moderate symptoms [ 3 ]. There has not been a standardized approach for preventing CIPN, thus careful monitoring and direction are required [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Physical therapists can do proactive assessment and screening for both sensory and motor functions, including fine motor skills, with the right tools and knowledge [ 17 ]. In a recently published study, the key role of physical therapists was also highlighted in the management of CIPN [ 3 ]. Despite the fact that there are plenty of CIPN evaluation methods reported in the literature, there is also an obvious inconsistency that exists between the diagnosis and rating of CIPN.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational study

Tuğral,

Arıbaş,

Akyol

et al. 2023

BMC Cancer

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Background Chemotherapy is a well-known risk factor for sensorial and motor disturbances. Chemotherapy induced peripheral neuropathy (CIPN) which predominantly affects sensory nerves might cause a diminished fine motor function. This prospective observational study aimed to assess the sensorimotor functions of breast cancer patients before, during, and after chemotherapy. Methods A total of 56 breast cancer patients were evaluated at three different times as follows: T1 (before chemotherapy), T2 (middle chemotherapy), and T3 (completion of chemotherapy). Motor function was assessed with handgrip strength (HGS), peripheral muscle strength (PMS), and the Minnesota Manual Dexterity Test (MMDT). Semmes Weinstein Monofilament Test (SWMT) was performed to assess the sensory function. Fatigue was evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Module Cancer Related Fatigue (EORTC-QLQ-FA12), respectively. Results HGS and MMDT were found significant (χ2: 11.279, p = 0.004 and χ2: 9.893, p = 0.007, respectively) whereas PMS was not found significant (F (2,110) = 1.914, p = 0.152). Pairwise comparisons with Bonferroni adjustments revealed that HGS was found significant between T1 and T3, while significant results were obtained between T1 and T2 as well as T2 and T3 in MMDT (p = 0.01 and p = 0.042). There were significant results in some reference points of SWMT, though they were not found after pairwise comparisons with Bonferroni adjustment (p > 0.05). Fatigue was found significantly increased from T1 through T3 (Median: 19.44 vs 27.77, z: -2.347, p = 0.019, Wilcoxon test). Conclusion Our study showed that decreased handgrip strength and fine motor function, as well as increased fatigue, are evident during the chemotherapy. SWMT can be an optional assessment in the context of tracking changes in cutaneous sensation during chemotherapy due to its non-invasive, cheap, and easily repeatable features among cancer patients. To preserve functional capacity as well as independence in daily living, precautions and follow up assessments during the systemic therapy process should be integrated as early as possible to prevent future deteriorations in daily life for patients who undergo chemotherapy. Trial registration NCT04799080.

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“…There are more than 230 000 physical therapists in the US compared with 13 000 oncologists and 7000 oncology advanced practice clinicians. 6 Training and uniting this diverse workforce is critical to delivering better care for patients with cancer. Exercise oncology has proven benefits for improving cancer-associated anxiety, depressive symptoms, fatigue, health-related quality of life, and physical function, with emerging evidence for CIPN, pain, sleep, and cognitive impairment.…”

mentioning

confidence: 99%

Exercise and Physical Medicine Interventions for Managing Chemotherapy-Induced Peripheral Neuropathy

Gupta,

Kleckner,

Lustberg

2024

JAMA Intern Med

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Framework to leverage physical therapists for the assessment and treatment of chemotherapy-induced peripheral neurotoxicity (CIPN)

Cited by 8 publications

References 97 publications

Rehabilitation in People Living with Glioblastoma: A Narrative Review of the Literature

Rehabilitation in People Living with Glioblastoma: A Narrative Review of the Literature

Assessment of sensorimotor and strength related function of breast cancer patients during systemic drug therapy: a prospective observational study

Exercise and Physical Medicine Interventions for Managing Chemotherapy-Induced Peripheral Neuropathy

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