This study analyzed the coverage by two partisan South Korean newspapers of the Middle East respiratory syndrome (MERS) pandemic, examining differences in their use of news frames and cited sources. A content analysis revealed that Hankyoreh, the left-wing newspaper, placed more emphasis on attributing responsibility to the government and society. In contrast, Chosun Ilbo, the right-wing newspaper, placed more emphasis on attributing responsibility to the individual. Severity/uncertainty, economic consequences, and statistical data frame were utilized more in Hankyoreh than the expected frequency. On the other hand, human interest and reassurance frame were utilized more in Chosun Ilbo than the expected frequency. Regarding the sources used in news stories, Hankyoreh used significantly more sources from local governments than did Chosun Ilbo. On the other hand, Chosun Ilbo used significantly more sources from medical agencies and experts than did Hankyoreh. This study advances previous research on the framing of a pandemic in the media by exploring how the partisan leanings of newspapers influence the framing.