Framing studies remain a powerful line of research in political communication. However, in recent years, coinciding with the emergence of social media, theoretical and operational advances have been detected, as well as a significant reorientation of its research agenda. The interaction between media and platforms such as Twitter or Facebook has built a clearly hybrid communicative environment and profoundly transformed the organization of public debate. This is the case, especially, with processes such as the setting of the public agenda or the construction of interpretive frames. Based on a systematic review of the international reference literature (2011–2021), this article analyses the influence of social media on the evolution of framing studies. Moreover, specifically, the beginning of a new stage of digital development is contextualized, and a triple research impact is explored. The main contributions of the text are that it (1) identifies advances in the theoretical and empirical organization of these studies; (2) explores its reorientation of content towards a greater balance between the analysis of media and political frames; and (3) reviews the recent experimental development of effects studies. Finally, the main challenges for future research in this field are detailed.