Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing Loss: A Preliminary Study

Chang, Young-Soo; Choi, Ji Eun; Ahn, Jong Hyeon; Ryu, Nam-Gyu; Moon, Il Joon; Hong, Sung Hwa; Cho, Yang-Sun; Chung, Wingyan

doi:10.1177/0003489417694910

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…Possible predictive factors of idiopathic sudden SNHL, such as patients’ demographics, hypertension, diabetes, 24,25 dyslipidaemia 24 and smoking, were used to calculate the Framingham risk score, revealing clinical applications. Although a previous study adopted the Framingham risk score as a prognostic tool for idiopathic sudden SNHL, 14 our current data demonstrate the clinical significance of using the Framingham risk score after adjusting for several possible factors. In addition, the present study demonstrates an overall successful recovery rate for those with idiopathic sudden SNHL of 48.7 per cent.…”

Section: Discussioncontrasting

confidence: 52%

“…This rate is higher than that reported in the previous study (23.8 per cent), which included only the patients with combined risk factors including hypertension, diabetes, hyperlipidaemia, and a history of malignant tumour or stroke. 14 These differences in the inclusion criteria between the two studies should be considered before interpreting and adjusting the results for clinical decision-making. The observations made in the current study might shed additional light on how to better formulate a prognosis for idiopathic sudden SNHL patients, regardless of multiple co-morbidities.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study suggested that the Framingham risk score may be a useful tool in predicting the prognosis for patients with idiopathic sudden SNHL and multiple co-morbidities. 14 In that study, authors demonstrated that the high-risk group (Framingham risk score of 20 per cent or higher) had poorer hearing recovery than the low-risk group in terms of their mean pure tone average (PTA) thresholds. As that study included patients with a combination of well-established risk factors, such as hypertension, diabetes, hyperlipidaemia, smoking and stroke, the overall successful recovery rate was only 23.81 per cent.…”

Section: Introductionmentioning

confidence: 98%

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Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss

et al. 2020

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ObjectiveTo assess the Framingham risk score as a prognostic tool for idiopathic sudden sensorineural hearing loss patients.MethodsMedical records were reviewed for unilateral idiopathic sudden sensorineural hearing loss patients between January 2010 and October 2017. The 10-year risk of developing cardiovascular disease was calculated. Patients were subdivided into groups: group 1 – Framingham risk score of less than 10 per cent (n = 28); group 2 – score of 10 to less than 20 per cent (n = 6); and group 3 – score of 20 per cent or higher (n = 5).ResultsInitial pure tone average and Framingham risk score were not significantly associated (p = 0.32). Thirteen patients in group 1 recovered completely (46.4 per cent), but none in groups 2 and 3 showed complete recovery. Initial pure tone average and Framingham risk score were significantly associated in multivariable linear regression analysis (R2 = 0.36). The regression coefficient was 0.33 (p = 0.003) for initial pure tone average and −0.67 (p = 0.005) for Framingham risk score.ConclusionFramingham risk score may be useful in predicting outcomes for idiopathic sudden sensorineural hearing loss patients, as those with a higher score showed poorer hearing recovery.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss

et al. 2020

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“…The etiology for ISSNHL is poorly understood and likely multifactorial. Previous research has supported a wide range of underlying comorbidities as being positively associated with ISSNHL, such as vascular, metabolic, allergic, autoimmune, and depressive disorders (4)(5)(6)(7)(8)(9)(10)(11). Environmental factors such as weather patterns have been explored as a potential contributor to disease incidence with little in the way of significant findings, with the possible role of seasonally-associated factors being alternately supported or refuted (12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Accelerated Long-Term Hearing Loss Progression After Recovery From Idiopathic Sudden Sensorineural Hearing Loss

et al. 2021

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Background and Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is characterized by rapid onset, typically unilateral presentation, and variable recovery. This case-control observational study aimed to improve patient counseling by objectively characterizing long-term hearing loss progression following ISSNHL, using sequential audiometry in the largest-to-date cohort of patients with ISSNHL.Methods: Patients diagnosed with ISSNHL at a tertiary referral hospital from 1994 through 2018 with sequential audiometry were studied. Case controls with sensorineural hearing loss (SNHL) were matched by age, sex, baseline hearing status, and frequency of sequential audiometry. Hearing loss progression was quantified using Kaplan–Meier (K–M) analysis to account for variable follow-up duration. A subgroup analysis was performed by age, sex, preexisting comorbidities, ISSNHL-associated symptoms, ISSNHL treatment, and degree of post-ISSNHL hearing recovery.Results: A total of 660 patients were identified with ISSNHL. In patients with post-ISSNHL recovery to good hearing [pure tone average (PTA) <30 dB and word recognition score (WRS) > 70%], median time to progression to non-serviceable (PTA > 50 dB or WRS <50%) SNHL was 16.4 years. In patients with incomplete post-ISSNHL hearing recovery, contralateral ears were also at significantly higher risk of SNHL progression over the following 12-year period. Male sex was associated with increased risk of SNHL progression [odds ratio (OR) 3.45 male vs. female] at 5-year follow up. No other subgroup factors influenced the likelihood of SNHL progression.Discussion and Conclusion: Patients should be counseled on continued risk to long-term hearing after stabilization of hearing post-ISSNHL, with particular emphasis on greater risk to the contralateral ear in those with incomplete ipsilateral recovery.

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“…10,11 Similarly, higher metabolic syndrome scores and higher branchial-ankle pulse wave velocity, representative for arterial stiffness, were associated with the development of vestibular neuritis, indicating an underlying vascular etiology. 12 Prior studies have demonstrated that Framingham Risk Scores (score of cardiovascular risk) may also be useful in predicting outcomes in idiopathic sudden sensorineural hearing loss, 13 but no further studies have demonstrated this relationship for vestibular function.…”

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confidence: 99%

Association Between Cardiometabolic Factors and Dizziness in African Americans: The Jackson Heart Study

et al. 2021

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Background Balance dysfunction is a complex, disabling health condition that can present with multiple phenotypes and etiologies. Data regarding prevalence, characterization of dizziness, or associated factors is limited, especially in an African American population. Purpose The aim of the study is to characterize balance dysfunction presentation and prevalence in an African American cohort, and balance dysfunction relationship to cardiometabolic factors. Research Design The study design is descriptive, cross sectional analysis. Study Sample The study sample consist of N = 1,314, participants in the Jackson Heart Study (JHS). Data Collection and Analysis JHS participants were presented an initial Hearing health screening questionnaire (N = 1,314). Of these, 317 participants reported dizziness and completed a follow-up Dizziness History Questionnaire. Descriptive analysis was used to compare differences in the cohorts' social-demographic characteristics and cardiometabolic variables to the 997 participants who did not report dizziness on the initial screening questionnaire. Based on questionnaire responses, participants were grouped into dizziness profiles (orthostatic, migraine, and vestibular) to further examine differences in cardiometabolic markers as related to different profiles of dizziness. Logistical regression models were adjusted for age, sex, education, reported noise exposure, and hearing sensitivity. Results Participants that reported any dizziness were slightly older and predominantly women. Other significant complaints in the dizzy versus nondizzy cohort included hearing loss, tinnitus, and a history of noise exposure (p < 0.001). Participants that reported any dizziness had significantly higher prevalence of hypertension, blood pressure medication use, and higher body mass index (BMI). Individuals with symptoms alluding to an orthostatic or migraine etiology had significant differences in prevalence of hypertension, blood pressure medication use, and BMI (p < 0.001). Alternatively, cardiometabolic variables were not significantly related to the report of dizziness symptoms consistent with vestibular profiles. Conclusion Dizziness among African Americans is comparable to the general population with regards to age and sex distribution, accordingly to previously published estimates. Participants with dizziness symptoms appear to have significant differences in BMI and blood pressure regulation, especially with associated orthostatic or migraine type profiles; this relationship does not appear to be conserved in participants who present with vestibular etiology symptoms.

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Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing Loss: A Preliminary Study

Abstract: Framingham Risk Scores may be useful in predicting outcomes for ISSHL patients with multiple comorbidities.

Cited by 9 publications

References 27 publications

Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss

Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss

Accelerated Long-Term Hearing Loss Progression After Recovery From Idiopathic Sudden Sensorineural Hearing Loss

Association Between Cardiometabolic Factors and Dizziness in African Americans: The Jackson Heart Study

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