As with anything creative, change is inevitable." -Enya T he Annals of Pharmacotherapy has been a mainstay in drug therapy literature since 1967. At its inception, it was the first journal to embrace and focus on the fledgling concept of clinical pharmacy. This early vision of the journal (Drug Intelligence its first two-and-a-half years and thereafter Drug Intelligence and Clinical Pharmacy, or DICP as it was affectionately known) was transformed into a reality by its first editor and publisher, Don Francke DSc. Journal content was such that practitioners, students, pharmacologists, and those interested in drug action and reaction could use the journal to educate themselves and others to further improve treatment options for patients. Key early series of articles on pharmacokinetics, drug interactions, pharmacoeconomics, and pharmacoepidemiology introduced these and other evolving concepts to practitioners and furthered their acceptance into the profession.As with many new endeavors, the theory of clinical pharmacy was sometimes difficult to put into action. 1 Perseverance and the support of the dedicated members of the journal's authors, Editorial Board members, reviewers, and translators, along with a similarly dedicated in-house staff, brought the journal to the forefront of clinical pharmacy publications. When Harvey AK Whitney, Jr. MSPharm assumed the role of editor and publisher in 1978 he continued to push for the journal to explore and introduce new concepts to broaden the scope of educational opportunities for readers and contributors alike.