Frecuencia de Streptococcus pneumoniae aislados de enfermedad invasiva en Paraguay, serotipos y perfil de sensibilidad (2010-2018)

León, María Eugenia; Kawabata, Akiko; Nagai, Minako; Rojas, Liliana; Zárate, Noemí; Irala, Juan; Gómez, Gloria; Ortellado, Juana; Leguizamón, Myrian; Franco, Rossana; Segovia, Nancy; Chamorro, Gustavo

doi:10.18004/mem.iics/1812-9528/2020.018.01.38-046

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serotypes found among pneumococci in the nasopharynx include the most common serotypes that caused invasive disease in Paraguay in the years prior to vaccine introduction (2010–2012) [ 41 ]. In addition, in this study, strains with resistance to antimicrobials were found more frequently in serotypes included in PCV10.The data on isolates from nasopharyngeal colonization can provide relevant information on the potential burden of pneumococcal disease and are important for understanding circulation before vaccination programs are implemented as well as for evaluating the impact after vaccine introduction in the country.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal colonization by Streptococcus pneumoniae in children and adults before the introduction of the 10-valent conjugate vaccine, Paraguay

et al. 2023

Self Cite

View full text Add to dashboard Cite

Streptococcus pneumoniae is a cause of invasive diseases such as pneumonia, meningitis, and other serious infections among children and adults in Paraguay. This study was conducted to establish S. pneumoniae baseline prevalence, serotype distribution, and antibiotic resistance patterns in healthy children aged 2 to 59 months and adults ≥60 years of age prior to the introduction of PCV10 in the national childhood immunization program in Paraguay. Between April and July 2012, a total of 1444 nasopharyngeal swabs were collected, 718 from children aged 2 to 59 months and 726 from adults ≥60 years of age. The pneumococcal isolation, serotyping, and antibiotic susceptibility testing were performed using standard tests. Pneumococcal colonization prevalence was 34.1% (245/718) in children and 3.3% (24/726) in adults. The most frequent pneumococcal vaccine-types (VT) detected in the children were 6B (42/245), 19F (32/245), 14 (17/245), and 23F (20/245). Carriage prevalence with PCV10 serotypes was 50.6% (124/245) and PCV13 was 59.5% (146/245). Among colonized adults, prevalence of PCV10 and PCV13 serotypes were 29.1% (7/24) and 41.6% (10/24), respectively. Colonized children were more likely to share a bedroom, have a history of respiratory infection or pneumococcal infection compared to non-colonized children. no associations were found in adults. However, no significant associations were found in children and neither in adults. Vaccine-type pneumococcal colonization was highly prevalent in children and rare in adults in Paraguay prior to vaccine introduction, supporting the introduction of PCV10 in the country in 2012. These data will be useful to evaluate the impact of PCV introduction in the country.

show abstract

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal colonization by Streptococcus pneumoniae in children and adults before the introduction of the 10-valent conjugate vaccine, Paraguay

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…For the three periods analysed were pre-vaccination (2006-2012), post-PCV10 (2013-2017) and post-PCV13 (2018-2020). A total of 885 S. pneumoniae isolates from cerebrospinal fluid (97), pleural fluid (263), blood (458) and bronchoalveolar lavage (57), as well as 278 PCR-positive/culture-negative clinical samples of cerebrospinal fluid (30), pleural fluid (241) and blood (7), were included.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…Some serotypes included in PCV13 still remain a cause of IPD, in particular 19A and 3 [6]. Although penicillin has been the treatment of choice for pneumococcal infection for a long period of time, the increased incidence of pneumococcal strains resistant to penicillin and other antibiotics threatens the treatment of pneumococcal infections [7]. Serotypes 19A, 6A, 6B, 9V, 14, 15A, 19F and 23F have shown the greatest resistance to penicillin and erythromycin, and many of them are included in the vaccines [8].…”

Section: Introductionmentioning

confidence: 99%

Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay

León

Samudio

Kawabata

et al. 2023

Journal of Medical Microbiology

Self Cite

View full text Add to dashboard Cite

Introduction. Streptococcus pneumoniae remains a major cause of mortality and morbidity worldwide in children <5 years of age, even with advances in vaccination programmes. Hypothesis/Gap Statement. Reviewing and reporting trends in the distribution of pneumococcal serotypes and antimicrobial resistance in Paraguay will be useful for decision-making in public health. Aim. This study analysed the serotype distribution and antimicrobial resistance of S. pneumoniae and the characteristics of pneumococcal disease in children <5 years old before and after the introduction of pneumococcal conjugate vaccines (PCVs). Methodology. A total of 885 isolates and 278 S. pneumoniae PCR-positive clinical specimens were referred to the Central Laboratory of Public Health (LCSP) within the meningitis and pneumonia laboratory based-surveillance network in the period 2006–2020. Conventional and molecular microbiological techniques were used for confirmation and characterization. Results. We identified 563 cases of pneumococcal disease in the pre-vaccination period, 325 cases in the post-PCV10 period and 275 cases in the post-PCV13 period. The serotypes covered by PCV10 decreased from 78.6–6.5 %. However, additional serotypes covered by PCV13 increased from 6.6–57.5% and non-PCV13 serotypes increased from 14.8–36.0 % (P<0.001) in the post-PCV13 period. In cases of meningitis, the rate of resistance to penicillin decreased after the introduction of conjugate vaccines. No resistance to ceftriaxone was found in any period. In cases without meningitis, the rate of resistance to penicillin and ceftriaxone decreased slightly. However, the rate of resistance to erythromycin and tetracycline increased and that to trimethoprim–sulfamethoxazole (SXT) decreased in the post-PCV13 period compared to the pre-PCV period. The multidrug resistance rate was 8.5 %. Conclusion. A change in the circulating serotypes and antimicrobial resistance to certain antibiotics was observed. Non-vaccine serotype circulation and multidrug resistance may compromise the success of the conjugate vaccines.

show abstract

Frecuencia de Streptococcus pneumoniae aislados de enfermedad invasiva en Paraguay, serotipos y perfil de sensibilidad (2010-2018)

Cited by 2 publications

References 0 publications

Nasopharyngeal colonization by Streptococcus pneumoniae in children and adults before the introduction of the 10-valent conjugate vaccine, Paraguay

Nasopharyngeal colonization by Streptococcus pneumoniae in children and adults before the introduction of the 10-valent conjugate vaccine, Paraguay

Serotypes and antimicrobial resistance of Streptococcus pneumoniae in children under 5 years of age pre- and post-pneumococcal conjugate vaccine introduction in Paraguay

Contact Info

Product

Resources

About