Frecuencias genotípicas y alélicas de apolipoproteina e (APOE) en una muestra de adultos en Bogotá

Gómez, Cladelis Rubio; Castañeda, Luz Dary Gutiérrez; Pedraza, Olga Lucía; Tobar, Lilian Torres; Acevedo, Gualberto Hernández; Camacho, Alfonso Suárez; Ruiz, Ángela Gisselle Lozano; Camacho-Bermúdez, Isis Norella

doi:10.31260/repertmedcir.01217372.1008

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“…27 , 28 The genotype frequencies of the APOΕ gene in our sample studied were similar to those described in Colombian, Latin American, and world literature. 26 A hazard ratio (HR) of 1.35 (95%CI 1.00–1.83) has been reported between the presence of the ϵ4 allele and the risk of AD, 29 whereas in a previous study in Colombia, it has been observed that the relationship has an OR of 5.1. 30…”

Section: Discussionmentioning

confidence: 96%

Association between Apoϵ4 allele and cardiometabolic and social risk factors with cognitive impairment in elderly population from Bogota

Pedraza

Camacho

Sierra

et al. 2021

Dement. neuropsychol.

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Being an ϵ4 carrier in the Apoϵ gene has been suggested as a modifying factor for the interaction between cardio-metabolic, social risk factors, and the development of cognitive impairment. Objective: The main objective of this study was to assess the existence of such interaction in a sample of Bogota’s elderly population. Methods: A cross-sectional study was conducted with 1,263 subjects older than 50 years. Each participant was diagnosed by consensus, after neuropsychological and neuropsychiatric evaluations, under a diagnosis of normal cognition, mild cognitive impairment (MCI) according to Petersen’s criteria, or dementia according to DSM-IV criteria. Apoϵ was typified and an analysis of MoCA test was performed in each group carrying or not ϵ4 allele. Results: Our study showed that 75% were women with a median age of 68 years (interquartile range 62–74 years) and a median schooling for 6 years (interquartile range 4–12 years). Dementia was related to low education level of ≤5 years OR=11.20 (95%CI 4.99–25.12), high blood pressure (HBP) OR=1.45 (95%CI 1.03–2.05), and age over 70 years OR=7.68 (95%CI 3.49–16.90), independently of being or not an ϵ4 allele carrier. Diabetic subjects with dementia carrying ϵ4 allele showed a tendency to exhibit lower scores on the MoCA test, when compared with noncarriers’ diabetic subjects with dementia. Conclusions: The presence of ϵ4 allele does not modify the relationship between cognitive impairment and the different cardio-metabolic and social risk factors, except in diabetic subjects ϵ4 carriers with dementia who showed a tendency to exhibit lower scores of the MoCA test, when compared with noncarriers’ diabetic subjects with dementia.

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Section: Discussionmentioning

confidence: 96%