Free amino acid excretion in tetraplegic patients

Claus-Walker, J; Rodriguez, Gladys P.

doi:10.1038/sc.1980.29

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…A progressive loss of muscle and collagen has been reported in tetraplegic patients, and the effectiveness of the exposed amino acid chains in the treatment and prediction of the course of the disease has been investigated (Claus‐Walker & Rodriguez, 1980 ). Additionally, in dogs with hepatic encephalopathy and severe cirrhosis, increased plasma aromatic amino acids such as tyrosine, phenylalanine, methionine and free tryptophan and a decrease in the branched chain amino acids, valine, leucine and isoleucine have been reported.…”

Section: Discussionmentioning

confidence: 99%

NMR‐based metabolomic investigation of dogs with acute flaccid paralysis due to tick paralysis

Gülersoy,

Balıkçı,

Şahan

et al. 2024

Veterinary Medicine & Sci

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BackgroundAcute flaccid paralysis (AFP) is a complex clinical syndrome with various aetiologies. If untreated, AFP may lead to death due to failure of respiratory muscles. Tick paralysis, which is a noninfectious neurologic syndrome of AFP, occurs following tick attachment, engorgement, and injection of tick saliva toxins. There is no specific diagnostic test for tick paralysis, and mortality increases as definitive diagnosis is delayed. Although metabolomic investigation of tick saliva was conducted, there is a lack of research on metabolomic evaluation of hosts affected by tick paralysis.ObjectivesThus, the aim of this study is to investigate metabolomic changes in serum samples of dogs with tick paralysis due to Rhipicephalus sanguineus using NMR‐based metabolomics and to identify potential diagnostic/prognostic markers.Materials and MethodsForty dogs infested with R. sanguineus, with clinical findings compatible with AFP and with a confirmed tick paralysis diagnosis ex juvantibus, constituted the Paralysis Group. Ten healthy dogs, which were admitted either for vaccination and/or check‐up purposes, constituted the Control Group. After the confirmation tick paralysis, medical history, vaccination and nutritional status, body surface area and estimated tick numbers of all the dogs were noted. Physical examination included body temperature, heart and respiratory rate, capillary refill time evaluation and Modified Glasgow Coma Scale calculation. Serum samples were extracted from venous blood samples of all the dogs and were prepared for NMR analysis, and NMR‐based metabolomics identification and quantification were performed.ResultsNMR‐based serum metabolomics of the present study revealed distinct up/down‐regulated expressions, presenting a promising avenue. Moreover, it was observed that energy metabolism and especially liver functions were impaired in dogs with tick paralysis, and not only the respiratory system but also the kidneys were affected.ConclusionIt was concluded that the present approach may help to better understand the pathological mechanisms developing in cases of AFP due to tick paralysis.

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Section: Discussionmentioning

confidence: 99%

NMR‐based metabolomic investigation of dogs with acute flaccid paralysis due to tick paralysis

Gülersoy,

Balıkçı,

Şahan

et al. 2024

Veterinary Medicine & Sci

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Body Composition in Quadriplegic Patients

Shizgal

Roza

Leduc

et al. 1986

J Parenter Enteral Nutr

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The nutritional state of 12 patients with quadriplegia, secondary to spinal cord injury, was assessed by determining body composition with a multiple isotope dilution technique. For comparative purposes, similar measurements were obtained in 25 normal volunteers. The mean duration of quadriplegia was 14.8 +/- 8.5 months. All the patients were hospitalized, receiving a regular hospital diet and all were on a similar rehabilitation program. Because skeletal muscle atrophy is extensive in quadriplegics, we had expected a reduced body size, which was otherwise normal in composition, with a comparable decrease in both the body cell mass (BCM) and the extracellular mass (ECM). Instead, a body composition characteristic of malnutrition was observed in an unexpectedly large percentage (58%) of patients. In the normally nourished individual, the BCM and ECM are approximately equal in size. However, in seven of the 12 quadriplegic patients, the body composition was characteristic of malnutrition, with a BCM (13.5 +/- 1.6 kg) which was reduced relative to the ECM (28.7 +/- 1.9 kg). Their body composition was significantly (p less than 0.05) different from the body composition of both the healthy volunteers and the other five quadriplegic patients, whose body composition was normal (BCM = 22.9 +/- 1.5 kg, ECM = 28.5 +/- 1.6 kg). The nutritional state of the quadriplegic patients correlated significantly with the level of spinal cord injury and not with the duration of quadriplegia.

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Nutritional and Metabolic Response to Acute Spinal‐Cord Injury

Kearns

Thompson

Werner

et al. 1992

J Parenter Enteral Nutr

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The metabolic response to complete spinal cord injury was prospectively studied in 10 patients with Frankel class A spinal cord injury. Weekly excretory and balance studies profile the changes in nitrogen, calcium, and 3-methylhistidine excretion in relation to body weight and metabolic rate. The initial resting energy expenditures were 10% below what was predicted, and body weight decreased by 10%. Nitrogen excretion paralleled the changes in body weight. Calcium excretion increased for 3 weeks and reached a plateau 150% above baseline. Our results chronicle the magnitude of metabolic response to spinal shock. Comparison with reported values shows this response exceeds that seen in immobilized patients. Nitrogen excretion rose to levels seen in highly stressed patients and must be considered in the management of patients with acute spinal-cord injury.

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Free amino acid excretion in tetraplegic patients

Cited by 3 publications

References 6 publications

NMR‐based metabolomic investigation of dogs with acute flaccid paralysis due to tick paralysis

NMR‐based metabolomic investigation of dogs with acute flaccid paralysis due to tick paralysis

Body Composition in Quadriplegic Patients

Nutritional and Metabolic Response to Acute Spinal‐Cord Injury

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