2012
DOI: 10.1007/s10517-012-1782-9
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Free and Protein-Bound Angiotensin II1-7 in the Regulation of Drinking Behavior and Hemodynamics in Rats

Abstract: We compared physiological activity of synthetic analogues of endogenous protein-peptide compounds, complexes of angiotensin II(1-7)with functionally different proteins (transport protein, serum albumin; and neurospecific Ca(2+)-binding protein, S100b). Physiological activity of angiotensin II(1-7)was shown to depend on the type of a carrier protein. Our results suggest that complexes of angiotensins with BSA and S100b are strong factors for the integration of central and peripheral functions at the homeostatic… Show more

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Cited by 1 publication
(3 citation statements)
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“…For example, AngII-BSA significantly enhances drinking behavior, so it is logical to assume a potentiating effect of this conjugate, similar to native AngII, on hemodynamic parameters, such as blood pressure and heart rate Notes: Hemodynamic effects: an increase (↑) or a decrease (↓) values are indicated, the percentage change in the measured parameters relative to the control is indicated in parentheses; behavioral effects: minus/plus means the absence/presence of an effect, the severity of which increases from minimum (+) to maximum (++++). The data were taken from Kotov et al, 2003;Pevtsova et al, 2008;Pevtsova et al, 2009;Tolpygo et al, 2012. Frontiers in Pharmacology | www.frontiersin.org November 2021 | Volume 12 | Article 772217 (Kaschina and Unger, 2003). However, the observed effects of AngII-BSA on hemodynamic parameters are much weaker when compared with AngII.…”
Section: Discussionmentioning
confidence: 99%
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“…For example, AngII-BSA significantly enhances drinking behavior, so it is logical to assume a potentiating effect of this conjugate, similar to native AngII, on hemodynamic parameters, such as blood pressure and heart rate Notes: Hemodynamic effects: an increase (↑) or a decrease (↓) values are indicated, the percentage change in the measured parameters relative to the control is indicated in parentheses; behavioral effects: minus/plus means the absence/presence of an effect, the severity of which increases from minimum (+) to maximum (++++). The data were taken from Kotov et al, 2003;Pevtsova et al, 2008;Pevtsova et al, 2009;Tolpygo et al, 2012. Frontiers in Pharmacology | www.frontiersin.org November 2021 | Volume 12 | Article 772217 (Kaschina and Unger, 2003). However, the observed effects of AngII-BSA on hemodynamic parameters are much weaker when compared with AngII.…”
Section: Discussionmentioning
confidence: 99%
“…Significantly, sometimes cardinally differing spectra of the activity of free and protein-bound angiotensins were demonstrated in a number of our works (Kotov et al, 2003;Pevtsova et al, 2008;Pevtsova et al, 2009;Tolpygo et al, 2012). For the study, central effector RASoctapeptide AngII and its derivatives heptapeptide Ang (1-7) and hexapeptide AngIV were selected.…”
Section: Modulation Of Angiotensin Activity By Conjugation With Proteinsmentioning
confidence: 99%
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