Free-breathing non-contrast-enhanced flow-independent MR angiography using magnetization-prepared 3D non-balanced dual-echo Dixon method: A feasibility study at 3 Tesla

Yoneyama, Masami; Zhang, Shuo; Hu, Houchun H.; Chong, Le Roy; Bardo, Dianna M. E.; Miller, Jeffrey H; Toyonari, Nobuyuki; Katahira, Kentaro; Katsumata, Yasutomo; Pokorney, Amber; Ng, Chian Keat; Kouwenhoven, Marc; Cauteren, Marc Van

doi:10.1016/j.mri.2019.08.017

Cited by 36 publications

(52 citation statements)

References 44 publications

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“…Recently, a Compressed SENSE accelerated 3D REACTnon-CE-MRA was introduced, which overcomes these limitations by the following: On the one hand, mDIXON XD combines the above-mentioned benefits of SSFP with reduced sensitivity to inhomogeneities in the magnetic field [20,40]. mDIXON XD provides robust suppression of fat and background and allows for separation of water and fat, consequently leading to insensitivity of REACTnon-CE-MRA to inhomogeneities in the magnetic field, even in large FOVs [41].…”

Section: Discussionmentioning

confidence: 99%

“…3D magnetizationprepared mDIXON XD (Philips Healthcare) was combined with a 30 ms T2 prep sequence. Since it was verifiable that background suppression of mDIXON XD in combination with T2 prep was sufficient for cardiovascular applications, no STIR preparation was applied, contrary to the original REACT sequence as introduced by Yoneyama et al [20]. To compensate for cardiac and respiratory motion, ECG-triggering (end-diastolic) and respiratory navigator-triggering were added to the originally proposed REACT sequence, therefore being referred to as "modified" REACT-non-CE-MRA throughout the manuscript.…”

Section: Image Acquisitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography

Pennig

Wagner

Weiss

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background: Patients with Congenital heart disease (CHD) require repetitive imaging of the pulmonary vasculature throughout their life. In this study, we compared a novel Compressed SENSE accelerated (factor 9) electrocardiogram (ECG)and respiratory-triggered 3D modified Relaxation-Enhanced Angiography without Contrast and Triggering (modified REACTnon-contrast-enhanced magnetic resonance angiography (modified REACT-non-CE-MRA)) with standard non-ECG-triggered time-resolved 4D CE-MRA for imaging of the pulmonary arteries and veins in patients with CHD. Methods: This retrospective analysis of 25 patients (June 2018-April 2019) with known or suspected CHD was independently conducted by two radiologists executing measurements on modified REACT-non-CE-MRA and 4D CE-MRA on seven dedicated points (inner edge): Main pulmonary artery (MPA), right and left pulmonary artery, right superior and inferior pulmonary vein, left superior (LSPV) and inferior pulmonary vein. Image quality for arteries and veins was evaluated on a four-point scale in consensus. Results: Twenty-three of the 25 included patients presented a CHD. There was a high interobserver agreement for both methods of imaging at the pulmonary arteries (ICC ≥ 0.96); at the pulmonary veins, modified REACT-non-CE-MRA showed a slightly higher agreement, pronounced at LSPV (ICC 0.946 vs. 0.895). Measurements in 4D CE-MRA showed higher diameter values compared to modified REACT-non-CE-MRA, at the pulmonary arteries reaching significant difference (e.g. MPA: mean 0.408 mm, p = 0.002). Modified REACT-non-CE-MRA (average acquisition time 07:01 ± 02:44 min) showed significant better image quality than 4D CE-MRA at the pulmonary arteries (3.84 vs. 3.32, p < 0.001) and veins (3.32 vs. 2.72, p = 0.015).

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Section: Discussionmentioning

confidence: 99%

Section: Image Acquisitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography

Pennig

Wagner

Weiss

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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“…1 of the supplemental material). For non-CE-MRA, imaging was based on a flow-independent 3D isotropic REACT sequence combining a 50 ms T2 preparation sequence and a STIR pulse with a 3D mDIXON XD (Philips Healthcare) readout [21]. The combination of T2 preparation and STIR enables the suppression of tissue with short T1 and T2, while enhancing the blood signal with long T1 and T2.…”

Section: Imagingmentioning

confidence: 99%

“…Recently, a novel 3D Relaxation-Enhanced Angiography without Contrast and Triggering (REACT) sequence, a combination of non-volume-selective short tau inversion recovery (STIR) and T2 preparation pulses with dual gradient echo Dixon (mDIXON XD) readout, was introduced. It combines the benefits of steady-state free precession (SSFP), such as bright-blood signal with robust fat and background suppression for flow-independent isotropic 3D non-CE-MRA [21]. While it is not suitable for intracranial MRA, REACT provides a simultaneous depiction of arterial and venous vessels and has shown encouraging results in displaying the pulmonary vasculature in congenital heart disease at 1.5 T [21,22].…”

Section: Introductionmentioning

confidence: 99%

Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT) for Fast Imaging of Extracranial Arteries in Acute Ischemic Stroke at 3 T

et al. 2020

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Purpose To evaluate a novel flow-independent 3D isotropic REACT sequence compared with CE-MRA for the imaging of extracranial arteries in acute ischemic stroke (AIS). Methods This was a retrospective study of 35 patients who underwent a stroke protocol at 3 T including REACT (fixed scan time: 2:46 min) and CE-MRA of the extracranial arteries. Three radiologists evaluated scans regarding vessel delineation, signal, and contrast and assessed overall image noise and artifacts using 5-point scales (5: excellent delineation/no artifacts). Apparent signal- and contrast-to-noise ratios (aSNR/aCNR) were measured for the common carotid artery (CCA), internal carotid artery (ICA, C1 segment), and vertebral artery (V2 segment). Two radiologists graded the degree of proximal ICA stenosis. Results Compared to REACT, CE-MRA showed better delineation for the CCA and ICA (C1 and C2 segments) (median 5, range 2–5 vs. 4, range 3–5; P < 0.05). For the ICA (C1 and C2 segments), REACT provided a higher signal (5, range 3–5; P < 0.05/4.5, range 3–5; P > 0.05 vs. 4, range 2–5) and contrast (5, range 3–5 vs. 4, range 2–5; P > 0.05) than CE-MRA. The remaining segments of the blood-supplying vessels showed equal medians. There was no significant difference regarding artifacts, whereas REACT provided significantly lower image noise (4, range 3–5 vs. 4 range 2–5; P < 0.05) with a higher aSNR (P < 0.05) and aCNR (P < 0.05) for all vessels combined. For clinically relevant (≥50%) ICA stenosis, REACT achieved a detection sensitivity of 93.75% and a specificity of 100%. Conclusion Given its fast acquisition, comparable image quality to CE-MRA and high sensitivity and specificity for the detection of ICA stenosis, REACT was proven to be a clinically applicable method to assess extracranial arteries in AIS.

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Simultaneous Highly Efficient Contrast‐Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease

Muñoz

Fotaki

Hua

et al. 2023

Magnetic Resonance Imaging

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BackgroundBright‐blood lumen and black‐blood vessel wall imaging are required for the comprehensive assessment of aortic disease. These images are usually acquired separately, resulting in long examinations and potential misregistration between images.PurposeTo characterize the performance of an accelerated and respiratory motion‐compensated three‐dimensional (3D) cardiac MRI technique for simultaneous contrast‐free aortic lumen and vessel wall imaging with an interleaved T2 and inversion recovery prepared sequence (iT2Prep‐BOOST).Study TypeProspective.PopulationA total of 30 consecutive patients with aortopathy referred for a clinically indicated cardiac MRI examination (9 females, mean age ± standard deviation: 32 ± 12 years).Field Strength/Sequence1.5‐T; bright‐blood MR angiography (diaphragmatic navigator‐gated T2‐prepared 3D balanced steady‐state free precession [bSSFP], T2Prep‐bSSFP), breath‐held black‐blood two‐dimensional (2D) half acquisition single‐shot turbo spin echo (HASTE), and 3D bSSFP iT2Prep‐BOOST.AssessmentiT2Prep‐BOOST bright‐blood images were compared to T2prep‐bSSFP images in terms of aortic vessel dimensions, lumen‐to‐myocardium contrast ratio (CR), and image quality (diagnostic confidence, vessel sharpness and presence of artifacts, assessed by three cardiologists on a 4‐point scale, 1: nondiagnostic to 4: excellent). The iT2Prep‐BOOST black‐blood images were compared to 2D HASTE images for quantification of wall thickness. A visual comparison between computed tomography (CT) and iT2Prep‐BOOST was performed in a patient with chronic aortic dissection.Statistical TestsPaired t‐tests, Wilcoxon signed‐rank tests, intraclass correlation coefficient (ICC), Bland–Altman analysis. A P value < 0.05 was considered statistically significant.ResultsBright‐blood iT2Prep‐BOOST resulted in significantly improved image quality (mean ± standard deviation 3.8 ± 0.5 vs. 3.3 ± 0.8) and CR (2.9 ± 0.8 vs. 1.8 ± 0.5) compared with T2Prep‐bSSFP, with a shorter scan time (7.8 ± 1.7 minutes vs. 12.9 ± 3.4 minutes) while providing a complementary 3D black‐blood image. Aortic lumen diameter and vessel wall thickness measurements in bright‐blood and black‐blood images were in good agreement with T2Prep‐bSSFP and HASTE images (<0.02 cm and <0.005 cm bias, respectively) and good intrareader (ICC > 0.96) and interreader (ICC > 0.94) agreement was observed for all measurements.Data ConclusioniT2Prep‐BOOST might enable time‐efficient simultaneous bright‐ and black‐blood aortic imaging, with improved image quality compared to T2Prep‐bSSFP and HASTE imaging, and comparable measurements for aortic wall and lumen dimensions.Evidence Level2.Technical EfficacyStage 2.

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Free-breathing non-contrast-enhanced flow-independent MR angiography using magnetization-prepared 3D non-balanced dual-echo Dixon method: A feasibility study at 3 Tesla

Cited by 36 publications

References 44 publications

Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography

Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography

Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT) for Fast Imaging of Extracranial Arteries in Acute Ischemic Stroke at 3 T

Simultaneous Highly Efficient Contrast‐Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease

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Free-breathing non-contrast-enhanced flow-independent MR angiography using magnetization-prepared 3D non-balanced dual-echo Dixon method: A feasibility study at 3 Tesla

Cited by 36 publications

References 44 publications

Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography

Imaging of the pulmonary vasculature in congenital heart disease without gadolinium contrast: Intraindividual comparison of a novel Compressed SENSE accelerated 3D modified REACT with 4D contrast-enhanced magnetic resonance angiography

Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT) for Fast Imaging of Extracranial Arteries in Acute Ischemic Stroke at 3 T

Simultaneous Highly Efficient Contrast‐Free Lumen and Vessel Wall MR Imaging for Anatomical Assessment of Aortic Disease

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Relaxation-Enhanced Angiography Without Contrast and Triggering (REACT) for Fast Imaging of Extracranial Arteries in Acute Ischemic Stroke at 3 T