Free‐Choice Alcohol Consumption in Mice After Application of the Appetite Regulating Peptide Leptin

Kiefer, Falk; Jahn, Holger; Wolf, Karsten D.; Kämpf, P.; Knaudt, Kristina; Wiedemann, Klaus

doi:10.1111/j.1530-0277.2001.tb02280.x

Cited by 47 publications

(18 citation statements)

References 17 publications

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“…Interestingly, alcohol consumption does not appear to follow this paradigm. Leptin administration significantly increased the consumption of ethanol in mice exposed to an ethanol deprivation-then-reinstatement procedure (144). High leptin levels at onset of alcohol withdrawal in humans were predictive of cravings and alcohol relapse; anti-opioid receptor drugs used to prevent relapse reduced leptin levels (145).…”

Section: Food-related Hormones Influence Dopaminergic Activity and Sementioning

confidence: 99%

Hunger and Satiety Gauge Reward Sensitivity

Cassidy

Tong

2017

Front. Endocrinol.

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Many of the neurocircuits and hormones known to underlie the sensations of hunger and satiety also substantially alter the activity of the dopaminergic reward system. Much interest lies in the ways that hunger, satiety, and reward tie together, as the epidemic of obesity seems tied to the recent development and mass availability of highly palatable foods. In this review, we will first discuss the basic neurocircuitry of the midbrain and basal forebrain reward system. We will elaborate how several important mediators of hunger—the agouti-related protein neurons of the arcuate nucleus, the lateral hypothalamic nucleus, and ghrelin—enhance the sensitivity of the dopaminergic reward system. Then, we will elaborate how mediators of satiety—the nucleus tractus solitarius, pro-opiomelanocortin neurons of the arcuate nucleus, and its peripheral hormonal influences such as leptin—reduce the reward system sensitivity. We hope to provide a template by which future research may identify the ways in which highly rewarding foods bypass this balanced system to produce excessive food consumption.

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Section: Food-related Hormones Influence Dopaminergic Activity and Sementioning

confidence: 99%

Hunger and Satiety Gauge Reward Sensitivity

Cassidy

Tong

2017

Front. Endocrinol.

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“…Leptin also regulates the hypothalamic–pituitary–adrenal (HPA) axis, which is involved in the neurobiology of alcohol craving (Adinoff et al 2005), and several studies suggest a role of leptin in the neurobiology of alcohol craving. For example, leptin may enhance motivation for alcohol consumption in habituated mice after alcohol withdrawal (Kiefer et al 2001a). Similarly, in AD subjects, plasma leptin is significantly higher than in healthy controls, and correlates with self-rated craving and decreases during withdrawal (Kiefer et al 2001b).…”

Section: Appetitive Hormonesmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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“…VTA and NAcc. Interestingly, both hormones have been invoked to play a role in alcohol and cocaine craving [35,36,37,38]. Therefore, these hormones may well be considered as forming the biological link between ‘chemical’ and behavioral food addiction.…”

Section: Overlap Between Chemical and Behavioral Addictionmentioning

confidence: 99%

Does Food Addiction Exist? A Phenomenological Discussion Based on the Psychiatric Classification of Substance-Related Disorders and Addiction

2012

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The relationship between overeating, substance abuse and (behavioral) addiction is controversial. Medically established forms of addiction so far pertain to substance use disorders only. But the preliminary Diagnostic and Statistical Manual for Mental Disorders V (DSM V) suggests replacing the previous category ‘Substance-Related Disorders’ with ‘Addiction and Related Disorders’, thus for the first time allowing the diagnosis of behavioral addictions. In the past psychiatrists and psychologists have been reluctant to systematically delineate and classify the term behavioral addiction. However, there is a broad overlap between chemical and behavioral addiction including phenomenological, therapeutic, genetic, and neurobiological aspects. It is of interest to point out that the hormone leptin in itself has a pronounced effect on the reward system, thus suggesting an indirect link between overeating and ‘chemical’ addiction. Thus, leptin-deficient individuals could be classified as fulfilling criteria for food addiction. In our overview we first review psychological findings in chemical (substance-based) and subsequently in behavioral addiction to analyze the overlap. We discuss the diagnostic validity of food addiction, which in theory can be chemically and/or behaviorally based.

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Free‐Choice Alcohol Consumption in Mice After Application of the Appetite Regulating Peptide Leptin

Abstract: We suggest that leptin may enhance motivation for alcohol consumption in habituated mice after alcohol withdrawal.

Cited by 47 publications

References 17 publications

Hunger and Satiety Gauge Reward Sensitivity

Hunger and Satiety Gauge Reward Sensitivity

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

Does Food Addiction Exist? A Phenomenological Discussion Based on the Psychiatric Classification of Substance-Related Disorders and Addiction

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