Free Cortisol of Human Plasma in the First Three Months of Life

Rokicki, W; Forest, Maguelone G.; Loras, B; Bonnet, H; J, Bertrand

doi:10.1159/000243148

Cited by 38 publications

(25 citation statements)

References 19 publications

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“…Any explanation for this low value must take into account the fact »that cortisol displays no circadian rhythm at this age. These low serum cortisol concentrations in neonates are in agreement with the results of Rockicki et al (6) and Forest (9). The work of Struckmeyer & Haid (8) showed no clear trend with age^ whereas Lashansky et al (7) found distinctly higher concentrations in infants.…”

Section: Discussionsupporting

confidence: 93%

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Establishment of Reference Ranges for Cortisol in Neonates, Infants, Children and Adolescents

Jonetz-Mentzel¹,

Wiedemann²

1993

Clinical Chemistry and Laboratory Medicine

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Summary:Cortisol was determined in the sera of 687 normal, healthy probands between the ages of 5 days and 18 years (neonates, infants, children and adolescents), using a fluorescence polarization immunoassay (FPIA) on the TDx from Abbott Laboratories. The proband collective was divided into 9 age groups and each group into males and females. In accordance with the recommendations of the International Federation of Clinical Chemistry, the 95% scatter range was taken as the reference range. Only a few reference groups showed a normal Gaussian distribution. In addition to the 50th percentile, the 2.5th and 97.5th percentiles were determined for all reference groups. Minimal and maximal values were also determined. The U-test of Mann & Whitney was used to test for significant differences between the individual reference groups. Groups showing no significant differences were combined, and reference ranges were finally calculated for eortisol in the serum of normal, healthy neonates, infants, children and adolescents. The serum eortisol concentration showed a significant increase with age. In the 14 -15 years age group, there was also a significant difference between males and females. IntroductionThe aim of the investigation was:

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Section: Discussionsupporting

confidence: 93%

“…Those childhood reference ranges that have appeared in the literature are shown in table 4 (6)(7)(8)(9). These data are not comparable with the present results for the following reasons:…”

Section: Discussionmentioning

confidence: 99%

Establishment of Reference Ranges for Cortisol in Neonates, Infants, Children and Adolescents

Jonetz-Mentzel¹,

Wiedemann²

1993

Clinical Chemistry and Laboratory Medicine

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“…Full-term neonates exhibited significantly higher salivary cortisol concentrations than healthy preterm neonates. In contrast, Rokicki et al [31]observed that free plasma cortisol concentrations in premature newborns at 3–5 days of life exceeded the values in full-term neonates, but their study protocol did not consider temporal changes of adrenal secretory activity and blood samples were randomly collected throughout the day. However, our data indicate that maxima of cortisol secretion already characterize adrenal activity in premature neonates and that the amplitude of these surges increases in the postnatal period.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Evaluation of Salivary Cortisol Levels in Full-Term and Preterm Neonates

Bettendorf¹,

Albers

Bauer³

et al. 1998

Horm Res Paediatr

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The aim of the present study was to test the practicability of sequential cortisol determinations in saliva of low birth weight neonates and to evaluate the impact of systemic and inhaled glucocorticoid therapy on saliva concentrations of cortisol in preterm neonates with bronchopulmonary dysplasia (BPD). Salivary cortisol levels were measured by RIA in saliva samples from 10 full-term and 10 preterm healthy neonates and from 20 preterm neonates with BPD during systemic [dexamethasone (DEX); n = 10] or topical steroid therapy [budesonide (BUD); n = 10]. Saliva samples of each individual were collected on 3 consecutive days at 06.00, 12.00, 18.00 and 24.00 h. Cortisol levels in saliva ranged from 0.8 to 60.6 nmol/l (median 6.5 nmol/l) in full-term neonates, from 0.6 to 52.1 nmol/l (median 5.5 nmol/l) in preterm neonates, from 0.4 to 14.0 nmol/l (median 1.0 nmol/l) in preterm neonates treated with DEX and from 0.4 to 15.2 nmol/l (median 2.5 nmol/l) in preterm neonates treated with BUD. Autocorrelation analysis revealed a distinct endogenous cortisol rhythm in 2 of the 10 healthy full-term neonates and in 3 of the 10 healthy preterm neonates with a wavelength of 12–30 h. Salivary cortisol levels in preterm neonates treated with DEX or BUD were significantly lower than those measured in healthy preterm neonates. These results demonstrate that the measurement of salivary cortisol levels is a reliable and practicable way of assessing adrenal function in full-term and preterm neonates. This study also shows for the first time that some neonates display an endogenous cortisol rhythm which is not coupled to the exogenous day/night cycle. Furthermore, systemic and nebulized glucocorticoids suppress adrenal function in low-birth-weight neonates. After treatment these children should be closely monitored for potential adrenal insufficiency.

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“…Healthy full-term neonates have mean serum cortisol concentrations of 339 nmol/l at the age of 0–6 h [23], and preterm infants at the same age have mean serum cortisol concentrations of 400 nmol/l [23]. During the first day of life, the serum cortisol concentration gradually declines [24, 25], and at the age of 3–10 days, average levels of 165–219 nmol/l in preterm, and 171–250 nmol/l in full-term infants have been measured [21, 25].…”

Section: Discussionmentioning

confidence: 99%

Antenatal and Early Postnatal Dexamethasone Treatment Decreases Cortisol Secretion in Preterm Infants

Karlsson

Kallio²,

Toppari

et al. 2000

Horm Res Paediatr

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Glucocorticoids are used antenatally to accelerate the maturation of fetal respiratory and cardiovascular systems when a threat of preterm delivery exists. Postnatally, they are used to prevent and treat respiratory distress syndrome. This study investigates the effects of antenatal (ACT) and early postnatal corticosteroid treatment (PCT) on serum cortisol and plasma catecholamine and adenosine 3′,5′-cyclic monophosphate (cAMP) concentrations in preterm neonates. The infants in the ACT group had a significantly lower cortisol concentration than the infants in the non-ACT group on the first day of life. After birth, the infants were further divided into non-PCT and PCT groups. PCT suppressed cortisol levels significantly after 2 days, and the cortisol levels were still lower 2 days after discontinuation of PCT. No effect of PCT on plasma cAMP or catecholamine concentrations was observed. The results indicate that both ACT and a short PCT can significantly suppress basal cortisol levels in preterm infants.

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Free Cortisol of Human Plasma in the First Three Months of Life

Cited by 38 publications

References 19 publications

Establishment of Reference Ranges for Cortisol in Neonates, Infants, Children and Adolescents

Establishment of Reference Ranges for Cortisol in Neonates, Infants, Children and Adolescents

Longitudinal Evaluation of Salivary Cortisol Levels in Full-Term and Preterm Neonates

Antenatal and Early Postnatal Dexamethasone Treatment Decreases Cortisol Secretion in Preterm Infants

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