Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease

Yadav, Ajay; Sata, Teja Naveen; Verma, Daksh; Sah, Amrendra Kumar; Mishra, Amit; Mrinalini, _; Hossain, Musa; Pant, Kishor; Venugopal, Senthil K.

doi:10.1016/j.iliver.2023.01.002

iLIVER

2023

DOI: 10.1016/j.iliver.2023.01.002

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Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease

Ajay Yadav

Teja Naveen Sata

Daksh Verma

et al.

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Cited by 5 publications

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Delphinidin or α‐amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high‐fat diet

Ali,

Elbaz,

Al‐Mokaddem

et al. 2024

BioFactors

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Non‐alcoholic fatty liver disease (NAFLD) is a liver pathology concomitant with metabolic disarrangement. This study assessed the therapeutic impacts of delphinidin, an anthocyanin, or α‐amyrin, a pentacyclic triterpenoid, on NAFLD in rats and the underlying mechanisms involved. NAFLD was established by feeding a high‐fat diet (HFD) for 10 weeks, either alone or in combination with delphinidin (40 mg/kg, oral) or α‐amyrin (20 mg/kg, oral). Delphinidin or α‐amyrin ameliorated the metabolic and histopathological perturbations induced by HFD. These compounds markedly attenuated NAFLD‐induced hepatic steatosis, as evidenced by a substantial decrease in body weight, insulin resistance, and liver and adipose tissue indices. Alongside normalization of the atherogenic index, both improved HFD‐mediated abnormalities in serum lipids, liver enzymes, leptin, and ghrelin levels. Moreover, their intervention activated the NFE2 like bZIP transcription factor 2 and heme oxygenase 1 pathways and abrogated HFD‐triggered activation of mitogen‐activated protein kinase 1 signaling. These remedies inhibited hepatic apoptosis and modulated the gene expression of lipogenic enzymes. Furthermore, histological analysis corroborated the suppression of lipid accumulation and amelioration of hepatic architecture in the treated rats. Our findings highlight the hepatoprotective value of delphinidin or α‐amyrin against NAFLD and related metabolic diseases through their insulin‐sensitizing, anti‐inflammatory, antioxidant, and antiapoptotic effects.

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Delphinidin or α‐amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high‐fat diet

Ali,

Elbaz,

Al‐Mokaddem

et al. 2024

BioFactors

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show abstract

MicroRNA-122 regulates inflammatory and autophagic proteins by downregulating pyruvate kinase M2 in non-alcoholic fatty liver disease

Hossain,

Mishra,

Yadav

et al. 2024

Mol Cell Biochem

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Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system

Hossain,

Mishra,

Yadav

et al. 2025

Annals of Hepatology

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Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease

Cited by 5 publications

References 60 publications

Delphinidin or α‐amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high‐fat diet

Delphinidin or α‐amyrin attenuated liver steatosis and metabolic disarrangement in rats fed a high‐fat diet

MicroRNA-122 regulates inflammatory and autophagic proteins by downregulating pyruvate kinase M2 in non-alcoholic fatty liver disease

Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system

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