Free Fatty Acid Metabolism during Perinatal Life

Free Fatty Acids and Glucose in the Plasma of Newly Born Lambs: Effects of Environmental Temperature

“…FFA levels were very low in the twin lamb delivered manually after a prolonged parturition and in the lambs that V an D uyne [16] subjected to severe oxygen deprivation in utero. Glucose levels in the twin were remarkably high; those in Van Duyne's lambs were not recorded.…”

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

“…Although such data must be interpreted cautiously, a fall of this magnitude is usually acceptable evidence of a change from the utilization of carbohydrate to the utilization of fat as a source of calories. after birth and fall off slowly thereafter, although at 1 yr. of age the free fatty-acid level is still higher than that in adults (Van Duyne & Havel, 1959;Novak, Melichar, Hahn & Koldovsky, 1961;Novak, Melichar & Hahn, 1965 a;Novak, Melichar, Hahn & Koldovsky, 19656;Van Duyne, 1966;Keele, Kay, Brown <fe Nordquist, 1966;Melichar, Novak, Zoula, Hahn & Koldovsky, 1966;Persson & Gentz, 1966;Melichar & Wolf, 1967;Milner & Wright, 1967). after birth and fall off slowly thereafter, although at 1 yr. of age the free fatty-acid level is still higher than that in adults (Van Duyne & Havel, 1959;Novak, Melichar, Hahn & Koldovsky, 1961;Novak, Melichar & Hahn, 1965 a;Novak, Melichar, Hahn & Koldovsky, 19656;Van Duyne, 1966;Keele, Kay, Brown <fe Nordquist, 1966;Melichar, Novak, Zoula, Hahn & Koldovsky, 1966;Persson & Gentz, 1966;Melichar & Wolf, 1967;Milner & Wright, 1967).…”

The glycogenolytic response to stimulation of the splanchnic nerves in adrenalectomized calves, sheep, dogs, cats and pigs

“…Evidence has accumulated in recent years to show that the control of carbohydrate metabolism in the young animal, during the period between birth and weaning, differs from that in the adult in a variety of ways (Shelley, 1961(Shelley, , 1969Edwards, 1966Edwards, , 1970van Duyne, 1966) and the situation is further complicated by wide differences between species (Shelley & Neligan, 1966). In the calf, removal of either the pituitary or of both adrenal glands results in death from hypoglycaemia within 24 hr in the absence of adequate replacement therapy (Comline & Edwards, 1965), whereas adult animals develop an increased sensitivity to the hypoglycaemic effect of insulin over a period of several weeks under these conditions but do not become hypoglycaemic spontaneously unless food is witheld (de Bodo & Altszuler, 1958).…”