Free Fatty Acid Scintigraphy in Patients with Successful Thrombolysis after Acute Myocardial Infarction

Fc, Visser; Westera, G.; Mj, van Eenige; Ee, van der Wall; Ga, Heidendal; Jp, Ross

doi:10.1097/00003072-198501000-00012

Cited by 19 publications

(2 citation statements)

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“…N Engl J Med 1986;314:884-888.) Visser and colleagues [59] performed myocardial imaging in 23 patients after injection of radioiodinated heptadecanoic acid during and 2 weeks, 3 months, and 12 months after thrombolytic therapy for acute myocardial infarction. Ischemia and hypoxia decrease the clearance rate and peak of this early component.…”

Section: Tissue Characterizationmentioning

confidence: 99%

Analytic Reviews : Detection of Viable Myocardium after Myocardial Infarction

Miller¹

1990

J Intensive Care Med

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The availability of effective therapeutic interventions to promote the acute salvage and subsequent definitive revascularization of jeoparized myocardium after a myocardial infarction has prompted the development of a number of noninvasive techniques for the detection of myocyte viability in this setting. Newly developed noninvasive metabolic probes (positron emission tomography [PET] and nuclear magnetic resonance [NMR] spectroscopy) may supplant available methods of regional ventricular function and perfusion assessment as the definitive techniques for determination of myocardial viability. Myocardial perfusion imaging with Thallium 201 or technetium-labeled isonitriles can be used acutely or in the chronic postinfarction setting to identify areas of residual blood flow. Regional wall motion changes assessed by radionuclide ventriculography or two-dimensional echocardiography may be correlated with perfusion imaging to improve the predictive value of thallium imaging for residual viability. Echocardiography tissue characterization, with or without the use of contrast agents, can be used to define the ischemic risk area and can experimentally distinguish infarcted from potentially viable myocardium. Accumulation of fluorine 18-labeled deoxyglucose and abnormal clearance of C 11-palmitate have been used to identify patients who may benefit from subsequent revascularization procedures. A similar discordance between flow and metabolic tracers is observed with single photon-emitting radionuclides such as iodophenylpentadecanoic acid. Proton NMR imaging is not yet able to distinguish viable from infarcted tissue, and NMR spectroscopy is now performed experimentally to identify changes in oxidative phosphorylation in infarcted and ischemic myocardium. 23NMR imaging following the administration of &dquo;shift&dquo; reagents has been experimentally evaluated for the detection of intracellular edema characteristic of irreversible ischemic injury.After infarction, markers of myocardial viability are less available than are methods for the diagnosis and quantification of myocardial necrosis. The focus of investigation has recently shifted from infarct size as a prognostic and therapeutic end point to the noninvasive determination of the functional and metabolic correlates of myocyte viability.The availability of effective therapeutic interventions to promote acute salvage and subsequent definitive revascularization of jeopardized myocardium after a myocardial infarction has prompted the development of a number of noninvasive techniques for the detection of myocyte viability in this setting. Newly developed noninvasive metabolic probes (e.g., positron emission tomography [PET] and nuclear magnetic resonance [NMR] spectros-

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Section: Tissue Characterizationmentioning

confidence: 99%

Analytic Reviews : Detection of Viable Myocardium after Myocardial Infarction

Miller¹

1990

J Intensive Care Med

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“…From the high RCV (4.2%) and the non-random distribution of the residuals it can be concluded that monoexponential curve fitting is mathematically inadequate. Monoexponential curve fitting, after background correction, has been used in most of the previous studies (1,4,6,7,9,(11)(12)(13) of myocardial metabolism. In normal myocardium the mean TV2 value equals the values found in this study after monoexponential plus constant curve fitting (about 22 min).…”

Section: Analysis Of Time-activity Curvesmentioning

confidence: 99%

Analysis of Myocardial Time-Activity Curves of 123I-Heptadecanoic Acid I. Curve Fitting

Eenige

Visser²,

Duwel³

et al. 1987

Nuklearmedizin

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Myocardial time-activity curves can be described by two or more parameters. To establish the optimal curve fitting method 33 myocardial time-activity curves were analyzed with different curve fitting methods: monoexponential, biexponential and monoexponential plus constant. A background correction was not applied. Biexponential curve fitting resulted in redundancy of parameters. Optimal curve fitting was obtained with monoexponential plus constant. The constant represents the background activity together with the stored radiolabelled lipids and the half-time value represents the wash-out of radioiodide from the myocardium. A strong relation was found between the constant and the half-time value: small errors in the determination of the constant (background activity) resulted in considerable errors of the half-time value. It is concluded that optimal analysis of a myocardial time-activity curve can be performed with a monoexponential plus constant without earlier correction for background activity.

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Myocardial imaging with radiolabeled free fatty acids: current views

Wall¹

1987

Developments in Cardiovascular Medicine

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Free Fatty Acid Scintigraphy in Patients with Successful Thrombolysis after Acute Myocardial Infarction

Cited by 19 publications

References 0 publications

Analytic Reviews : Detection of Viable Myocardium after Myocardial Infarction

Analytic Reviews : Detection of Viable Myocardium after Myocardial Infarction

Analysis of Myocardial Time-Activity Curves of 123I-Heptadecanoic Acid I. Curve Fitting

Myocardial imaging with radiolabeled free fatty acids: current views

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