Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

Zhang, Huiwen; Zhao, Xiaoyan; Guo, Yuan‐Lin; Zhu, Cheng‐Gang; Wu, Na‐Qiong; Sun, Jing; Li, Geng; Dong, Qian; Li, Jianjun

doi:10.1186/s12986-017-0195-1

Cited by 16 publications

(9 citation statements)

References 33 publications

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“…Cardiovascular disease represents the most frequent cause of death in well-developed regions, and the number of cardiovascular disease cases is also increasing in the developing regions accompanied by economic growth [1]. As a common cardiovascular disease, coronary artery disease (CAD) ranks as the first cause of mortality across the globe owing to the adverse clinical events [2]. The risk factors contributing to CAD have been well recognized, such as high blood pressure, lipid disorders, cigarette smoking, as well as physical inactivity [3,4].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of microRNA-136-3p Alleviates Myocardial Injury in Coronary Artery Disease via the Rho A/ROCK Signaling Pathway

Lin

Dan

2020

Kidney Blood Press Res

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KeywordsCoronary artery disease · MicroRNA-136-3p · Cardiac microvascular endothelial cells · EIF5A2 · Rho A/ROCK signaling pathway Abstract Objective: Coronary artery disease (CAD) is a cardiovascular disease that poses a fatal threat to human health, and the identification of potential biomarkers may help to delineate its pathophysiological mechanisms. Accumulating evidence has implicated microRNAs (miRNAs) in the pathogenesis and development of cardiovascular diseases. The present study aims to identify the expression of miRNA-136-3p (miR-136-3p) in CAD and further investigate its functional relevance in myocardial injury both in vitro and in vivo. Methods: Initially, CAD models were induced in rats by high-fat diet and intraperitoneal injection of pituitrin. Next, the effect of overexpressed miR-136-3p on cardiac function and pathological damage in myocardial tissue, cardiomyocyte apoptosis, oxidative stress and inflammatory response were assessed in CAD rats. Rat cardiac microvascular endothelial cells (CMECs) were isolated and cultured by the tissue explant method, and the CMEC injury model was induced by homocysteine (HCY). The function of miR-136-3p in vitro was further evaluated. Results: miR-136-3p was poorly expressed in the myocardial tissue of CAD rats and CMEC injury models. In vivo assays indicated that overexpressed miR-136-3p could improve cardiac function and alleviate pathological damage in myocardial tissue, accompanied by reduced oxidative stress and inflammatory response. Moreover, in vitro assays suggested that overexpression of miR-136-3p enhanced proliferation and migration while inhibiting apoptosis of HCY-stressed CMECs. Notably, we revealed that EIF5A2 was a target gene of miR-136-3p, and miR-136-3p inhibited EIF5A2 expression and activation of the Rho A/ROCK signaling pathway. Conclusion: In conclusion, the overexpression of miR-136-3p could potentially impede myocardial injury in vitro and in vivo in CAD through the blockade of the Rho A/ROCK signaling pathway, highlighting a potential miR-136-3p functional relevance in the treatment of CAD.

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Section: Introductionmentioning

confidence: 99%

Overexpression of microRNA-136-3p Alleviates Myocardial Injury in Coronary Artery Disease via the Rho A/ROCK Signaling Pathway

Lin

Dan

2020

Kidney Blood Press Res

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“…It was demonstrated in AleCardio trial that a twofold higher baseline FFAs was directly associated with 17% higher risk of MACEs in patients with both T2DM and ACS [9]. The study by our group also reported that the HR for fourth FFAs quartile was 1.80 after adjustment for traditional cardiovascular risk factors when compared with that in the first FFAs quartile [25]. In the IMMEDIATE trial, very early intravenous glucose-insulin-potassium for ACS patients could suppress FFAs and ultimately result in less cardiac arrest and in-hospital mortality [26].…”

Section: Discussionmentioning

confidence: 89%

Impact of free fatty acids on prognosis in coronary artery disease patients under different glucose metabolism status

Jin

Cao

Liu

et al. 2019

Cardiovasc Diabetol

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Background The aim of the present study is to examine the effects of free fatty acids (FFAs) on major cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) and different glucose metabolism status. Methods In this study, we consecutively enrolled 5443 patients from March 2011 to May 2015. Patients were categorized according to both status of glucose metabolism status [diabetes mellitus (DM), pre-diabetes (Pre-DM), normal glycaemia regulation (NGR)] and FFAs levels. All subjects were followed up for the occurrence of the MACEs. Results During a median of 6.7 years’ follow-up, 608 MACEs occurred. A twofold higher FFAs level was independently associated with MACEs after adjusting for confounding factors [Hazard Ratio (HR): 1.242, 95% confidence interval (CI) 1.084–1.424, p value = 0.002]. Adding FFAs to the Cox model increased the C-statistic by 0.015 (0.005–0.027). No significant difference in MACEs was observed between NGR and Pre-DM groups (p > 0.05). When patients were categorized by both status of glucose metabolism and FFAs levels, medium and high FFAs were associated with significantly higher risk of MACEs in Pre-DM [1.736 (1.018–2.959) and 1.779 (1.012–3.126), all p-value < 0.05] and DM [2.017 (1.164–3.494) and 2.795 (1.619–4.824), all p-value < 0.05]. Conclusions The present data indicated that baseline FFAs levels were associated with the prognosis in DM and Pre-DM patients with CAD, suggesting that FFAs may be a valuable predictor in patients with impaired glucose metabolism.

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“…Huber et al 13 have proved FFAs are an independent risk factor in predicting mortality in patients with ST-segment elevated MI. Moreover, our previous study also indicated that FFAs presented as an independent risk factor for cardiovascular events in Chinese patients with stable CAD 14. However, the role of FFAs in postprocedural myocardial infarction has not been reported yet.…”

Section: Discussionmentioning

confidence: 92%

Free fatty acids as a marker for predicting periprocedural myocardial injury after coronary intervention

Wang

Zhang

Guo

et al. 2019

Postgraduate Medical Journal

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BackgroundPrevious studies have revealed that plasma levels of free fatty acids (FFAs) are related to cardiovascular risk. However, whether FFAs could predict periprocedural myocardial injury (PMI) following percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) remains unclear.PurposeThis study aimed to investigate the relationship of FFAs to PMI in untreated patients with CAD who underwent PCI.MethodsA total of 374 consecutive patients with CAD without lipid-lowering treatment on admission and with normal preprocedural cardiac troponin I (cTnI) levels who underwent PCI were prospectively enrolled. The baseline characteristics were collected and PMI was evaluated by cTnI analysis within 24 hours. The relation of preprocedural FFA levels to peak cTnI values after PCI was examined.ResultsPreprocedural FFAs were positively correlated with peak cTnI values after PCI in both simple regression model (β=0.119, p=0.021) and multiple regression model (β=0.198, p=0.001). Patients with higher FFA levels had higher postprocedural cTnI levels compared with those with normal FFA levels (0.27±0.68 ng/mL vs 0.66±0.31 ng/mL, p=0.014). In the multivariable model, preprocedural FFA levels were associated with an increased risk of postprocedural cTnI elevation above 1× upper limit of normal (ULN, OR: 1.185, 95% CI 0.997 to 1.223, p=0.019) up to 10× ULN (OR: 1.132, 95% CI 1.005 to 1.192, p=0.003) .ConclusionsThe present study first suggested that elevated FFA levels were associated with an increased risk of PMI in untreated patients with CAD. Further study with large sample size may be needed to confirm our findings.

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Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

Cited by 16 publications

References 33 publications

Overexpression of microRNA-136-3p Alleviates Myocardial Injury in Coronary Artery Disease via the Rho A/ROCK Signaling Pathway

Overexpression of microRNA-136-3p Alleviates Myocardial Injury in Coronary Artery Disease via the Rho A/ROCK Signaling Pathway

Impact of free fatty acids on prognosis in coronary artery disease patients under different glucose metabolism status

Free fatty acids as a marker for predicting periprocedural myocardial injury after coronary intervention

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