2023
DOI: 10.21203/rs.3.rs-3400800/v1
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Free-heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-kB signaling pathway

Xin Wei,
Fan Zhang,
Dan Cheng
et al.

Abstract: Background: Red blood cells (RBCs) transfusion is related to perioperative neurocognitive disorders. The toxic effect of free-heme has been identified in many pathologies. However, the underlying mechanisms of RBCs transfusion or free-heme in cognitive impairment have not been clearly explored. Therefore, this research was conducted to determine the mechanism of heme-induced neuroinflammation and cognitive impairment. Methods: Rats were received intraperitoneal injection of hemin alone or combined with intrace… Show more

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