Free intraperitoneal tumor cells and outcome in gastric cancer patients: a systematic review and meta-analysis

Pecqueux, Mathieu; Fritzmann, Johannes; Adamu, Mariam; Thorlund, Kristian; Kahlert, Christoph; Reißfelder, Christoph; Weitz, Jürgen; Rahbari, Nuh N.

doi:10.18632/oncotarget.5595

Cited by 35 publications

(33 citation statements)

References 98 publications

(216 reference statements)

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“…Similar to Pecqueux et al 106, our study also revealed a high level of heterogeneity for recurrence rates. This finding could be explained by the different follow-up programs of each oncologic center, including different adjuvant therapies and methodologies for diagnosing recurrence.…”

Section: Discussionsupporting

confidence: 90%

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Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis

Tustumi¹,

Bernardo²,

Dias³

et al. 2016

Clinics

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Intraperitoneal free cancer cells in gastric adenocarcinoma are associated with a poor outcome. However, the true prognostic value of intraperitoneal free cancer cells is still unclear, leading to a lack of consensus in the management of gastric cancer. The aim of the present study is to perform a systematic review and meta-analysis to analyze intraperitoneal free cancer cells-positive patients with regard to tumor oncologic stage, recurrence, grade of cellular differentiation, and survival rates and to analyze the clinical significance of intraperitoneal free cancer cells with regard to prognosis. Databases were searched up to January 2016 for prognostic factors associated with intraperitoneal free cancer cells, including oncologic stage, depth of neoplasm invasion, lymph nodal spread, differentiation grade of the tumor, and recurrence and survival rates. A total of 100 studies were identified. Meta-analysis revealed a clear association between intraperitoneal free cancer cells and a poor prognosis. intraperitoneal free cancer cells -positive patients had higher rates of nodal spread (risk difference: 0.29; p<0.01), serosal invasion (risk difference: 0.43; p<0.01), recurrence (after 60 months of follow-up, risk difference: 0.44; p<0.01), and mortality (after 60 months of follow-up, risk difference: 0.34; p<0.01). Intraperitoneal free cancer cells are associated with a poor outcome in gastric cancer. This surrogate biomarker should be used to guide therapy both prior to and after surgery.

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Section: Discussionsupporting

confidence: 90%

“…Pecqueux et al 106 also analyzed the relationship between IFCCs and survival and recurrence rates. However, they compared studies that evaluated recurrence and survival rates at different times, which compromised the validity of the findings.…”

Section: Discussionmentioning

confidence: 99%

Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis

Tustumi¹,

Bernardo²,

Dias³

et al. 2016

Clinics

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“…Though patients were explored for metastatic disease prior to resection, routine peritoneal washings were not performed in the earlier study period. Many studies have demonstrated the association between free intraperitoneal tumor cells and poor survival and peritoneal recurrence (34)(35)(36). It is possible that LP patients had a greater likelihood of undiagnosed peritoneal disease and hence survival rates were lowered.…”

Section: Discussionmentioning

confidence: 99%

Does histology really influence gastric cancer prognosis?

Luu¹,

Thapa²,

Woo³

et al. 2017

J. Gastrointest. Oncol.

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Background: Gastric cancer (GC) is associated with poor survival despite curative-intent surgical resection and systemic therapy. Our objective is to examine the impact of histology on prognosis as well as the impact of linitis plastica (LP) on survival. Methods:The GC database at a single institution was evaluated for patients who underwent resection from 2000 to 2015. Clinicopathologic characteristics were examined and descriptive statistics was used to analyze four groups of patients based on Lauren classification: intestinal (n=93), diffuse (n=20), diffuse with signetring cell features (n=57), and LP (n=40). LP patients had diffuse GC but also presented with circumferential infiltration of the gastric wall for at least a third of the stomach length on endoscopy or imaging. Fisher's exact test was used to compare groups; Cox regression was used for multivariate analysis and Kaplan-Meier method for survival. Results: Of 210 patients who underwent gastric resection, 112 (53%) were male with mean age 65.3 years (SD ±14.6 years). Intestinal GC patients were older at diagnosis but other patient demographics were similar between all groups. LP patients had a higher rate of R1 resection despite higher rates of total gastrectomy (P<0.01). Rates of perineural invasion (PNI) and nodal metastasis were higher in LP (P<0.001). The majority of intestinal GC patients (79%) had stage I/II disease compared to 70% of LP patients with stage III disease.Median overall survival (OS) was 13.7 months for LP, 79 months for intestinal, 97 months for signetring cell, and not reached for diffuse GC (P<0.001). When stratified by stage, there were no significant differences in survival by histology for stage II and stage III patients. However, by Cox regression analysis, factors associated with worse survival included lymphovascular invasion (LVI), nodal disease, and presence of LP. Neutrophil-lymphocyte ratio (NLR), neoadjuvant and adjuvant therapy, and tumor regression grade did not influence survival on multivariate analysis. Conclusions:Intestinal GC is thought to have a better prognosis. Interestingly, this study demonstrates similar outcomes in patients with intestinal, diffuse, and signet-ring cell GC. However, a subset of diffuse GC-LP was associated with an infiltrative pattern of disease characterized by PNI and LVI. Despite controlling for poor prognostic markers, LP was independently associated with a worse prognosis. More research is needed to identify methods of earlier diagnosis and effective systemic therapy to treat this aggressive disease.

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“…As for the two other gastric cancer cell strains, N87 and SGC7901 cells had elevated ANGPTL2 protein expression levels that were slightly lower compared to normal levels. The probable explanation is that the N87 and SGC7901 cell lines had a lower metastatic capacity and the BGC823 and PAMC82 cell lines had a higher degree of malignancy, which exhibited strong migratory ability[32-34]. Recent studies have reported that the carcinogenic capacity of PAMC82 cells is higher than that of N87 cells[35,36].…”

Section: Discussionmentioning

confidence: 99%

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

Sheng¹,

Chen²,

Tu³

et al. 2016

WJG

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AIMTo explore expression of angiopoietin-like protein 2 (ANGPTL2) and its effect on biological behavior such as proliferation and invasiveness in gastric cancer.METHODSWestern blotting was used to detect expression of ANGPTL2 in 60 human normal gastric tissues, 60 human gastric cancer tissues and gastric cell lines including GES-1, N87, SGC7901, BGC823 and PAMC82. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Transwell assay were used to detect the proliferation and invasive ability of gastric cancer cells.RESULTSCompared to normal tissues, ANGPTL2 protein levels were significantly upregulated in gastric tissues, and this level was closely correlated with gastric tumor grade, clinical stage and lymph node metastasis. Compared to GES-1 cells, ANGPTL2 mRNA and protein levels were significantly increased in gastric cancer cells including N87, SGC7901, BGC823 and PAMC82. The expression of ANGPTL2 in highly malignant gastric cancer cell lines BGC823 and PAMC82 was significantly higher than in low malignancy gastric cancer cell lines N87 and SGC7901. MTT and Transwell experiments indicated that the proliferation rate and invasive ability of stable overexpressed gastric cancer cells was faster than in cells transfected with Lv-NC and blank control cells, and the invasive ability of stable overexpressed gastric cancer cells was higher than that of cells transfected with Lv-NC and blank control cells.CONCLUSIONANGPTL2 contributed to proliferation and invasion of gastric cancer cells. In clinical treatment, ANGPTL2 may become a new target for treatment of gastric cancer.

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Free intraperitoneal tumor cells and outcome in gastric cancer patients: a systematic review and meta-analysis

Cited by 35 publications

References 98 publications

Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis

Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis

Does histology really influence gastric cancer prognosis?

ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

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