Free leptin, carotid plaque phenotype and relevance to related symptomatology: Insights from the OPAL-Lille carotid endarterectomy study

Elkalioubie, Ahmed; Zawadzki, Christophe; Roma-Lavisse, Charlotte; Chinetti-Gbaguidi, Giulia; Tagzirt, Madjid; Corseaux, Delphine; Juthier, Françis; Vaast, Bertrand; Vanhoutte, Jonathan; Vincentelli, André; Jude, Brigitte; Haulon, Stéphan; Staels, Bart; Susen, Sophie; Belle, Éric Van; Dupont, Annabelle

doi:10.1016/j.ijcard.2013.07.048

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Another well studied adipokine, leptin, has been suggested to induce vascular endothelial dysfunction [28] and VSMC proliferation [29]. Also, resistin, which is elevated in obesity and T2DM, was found to be a strong risk factor for acute coronary syndrome in different clinical studies [30].…”

Section: Pathophysiology Of Diabetic Vascular Diseasementioning

confidence: 99%

Making Sense in Antisense: Therapeutic Potential of Noncoding RNAs in Diabetes-Induced Vascular Dysfunction

Eken

Jin

Chernogubova

et al. 2013

Journal of Diabetes Research

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The rapid rise of type II diabetes mellitus and its accompanying vascular complications call for novel approaches in unravelling its pathophysiological mechanisms and designing new treatment modalities. Noncoding RNAs represent a class of previously unknown molecular modulators of this disease. The most important features of diabetes-induced vascular disease, which include metabolic deregulation, increased oxidative stress, release of inflammatory mediators like adipokines, and pathologic changes in vascular cells, all are depicted and governed by a certain set of noncoding RNAs. While these mechanisms are being unravelled, new diagnostic and therapeutic opportunities to treat diabetes-induced vascular disease emerge.

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Section: Pathophysiology Of Diabetic Vascular Diseasementioning

confidence: 99%

Making Sense in Antisense: Therapeutic Potential of Noncoding RNAs in Diabetes-Induced Vascular Dysfunction

Eken

Jin

Chernogubova

et al. 2013

Journal of Diabetes Research

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Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways

et al. 2017

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Taken together, these findings indicate that leptin plays a critical role in CAVD development by promoting osteoblast differentiation of human aortic VICs in an Akt- and ERK-dependent manner. This study highlights the role of leptin in CAVD development, and further studies are needed to determine whether reducing circulating leptin levels or blocking leptin actions on VICs is efficient to slow CAVD progression.

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Free leptin, carotid plaque phenotype and relevance to related symptomatology: Insights from the OPAL-Lille carotid endarterectomy study

Cited by 2 publications

References 10 publications

Making Sense in Antisense: Therapeutic Potential of Noncoding RNAs in Diabetes-Induced Vascular Dysfunction

Making Sense in Antisense: Therapeutic Potential of Noncoding RNAs in Diabetes-Induced Vascular Dysfunction

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways

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