Free Marine Natural Products Databases for Biotechnology and Bioengineering

Barbosa, Arménio Jorge Moura; Roque, Ana C. A.

doi:10.1002/biot.201800607

Cited by 22 publications

(14 citation statements)

References 81 publications

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“…While a significant quantity of active compounds has been isolated from marine algae and added to the compound databases [ 233 , 234 , 235 , 236 , 237 , 238 ] every year, it is disappointing that very few of them have access to clinical trial and the success rate is also not very satisfactory. In this context, the current strategy of drug development requires a reformation with the inclusion of some modern approaches, such as virtual screening and network pharmacology.…”

Section: Algal Metabolites-based Drug Discovery and Designmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

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Section: Algal Metabolites-based Drug Discovery and Designmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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“…The marine environment, which occurs in three-quarters of the globe's surface in seas and oceans, is the largest habitat on earth, featuring an enormous level of biodiversity with many still unknown species, and it is not yet exploited extensively in terms of bioactive natural products. Marine biotechnology and pharmacology represent key ever-evolving issues based on the utilization of marine natural resources [16,17]. In fact, animal adaptation processes for the different and sometimes hostile aquatic environments have led to the promotion and accumulation of a remarkable genetic and biochemical variability, with the consequence that the compounds produced often display prominent differences with respect to those from terrestrial species.…”

Section: The Marine Animal Species As a Source Of Bioactive Moleculesmentioning

confidence: 99%

Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells

Luparello

2021

Foundations

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It is known that in breast cancer biology, autophagy mainly plays a cytoprotective and anti-apoptotic role in vitro, being conceivably responsible for cell resistance to drug exposure and a higher metastatic attitude in vivo. Thus, the development of novel autophagy-targeting agents represents a valuable strategy to improve the efficacy of anticancer interventions. It is widely acknowledged that the enormous biodiversity of marine organisms represents a highly promising reserve for the isolation of bioactive primary and secondary metabolites targeting one or several specific molecular pathways and displaying active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of marine animal-derived extracts or isolated compounds which exert a modulatory effect on the autophagic process in breast cancer cells and list them with respect to the taxonomical hierarchy of the producing species. Where available, the molecular and biochemical aspects associated with the molecules or extracts under discussion will be also summarized.

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“…While a significant quantity of active compounds has been isolated from marine algae and added to the compound databases [213][214][215][216][217][218] every year, it is disappointing that very few of them have access to clinical trial and the success rate is also not very satisfactory. In this context, the current strategy of drug development requires a reformation with the inclusion of some modern approaches, such as virtual screening and network pharmacology.…”

Section: Algal Metabolites-based Drug Discovery and Designmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Hannan¹,

Dash²,

Haque³

et al. 2020

Preprint

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer's disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

show abstract

Free Marine Natural Products Databases for Biotechnology and Bioengineering

Cited by 22 publications

References 81 publications

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

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