Free Phenols in Maize Pith and Their Relationship with Resistance to &lt;I&gt;Sesamia nonagrioides&lt;/I&gt; (Lepidoptera: Noctuidae) Attack

Santiago, Rogelio; Malvar, R. A.; Baamonde, M. D.; Revilla, Pedro; Souto, X. Carlos

doi:10.1603/0022-0493-98.4.1349

Cited by 41 publications

(32 citation statements)

References 51 publications

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“…On the basis of these rules we have since searched for further potential candidates to inhibit FGFs, examining different libraries of natural products. We found that gentisic acid (GA; 2,5-dihydroxybenzoic acid), a widespread plant secondary metabolite involved in pest defense and a catabolite of aspirin, is a potential inhibitor of FGF (27)(28)(29)(30)(31)(32). Here we show that GA does indeed define a new chemical group of FGF inhibitors, which includes homogentisic acid (HGA; 2-(2,5-dihydroxyphenyl)acetic acid), the toxic agent in alkaptonuria.…”

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confidence: 92%

Gentisic Acid, a Compound Associated with Plant Defense and a Metabolite of Aspirin, Heads a New Class of in Vivo Fibroblast Growth Factor Inhibitors

Fernandez

Cuevas

Angulo

et al. 2010

Journal of Biological Chemistry

106

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Fibroblast growth factors are key proteins in many intercellular signaling networks. They normally remain attached to the extracellular matrix, which confers on them a considerable stability. The unrestrained accumulation of fibroblast growth factors in the extracellular milieu, either due to uncontrolled synthesis or enzymatic release, contributes to the pathology of many diseases. Consequently, the neutralization of improperly mobilized fibroblast growth factors is of clear therapeutic interest. In pursuing described rules to identify potential inhibitors of these proteins, gentisic acid, a plant pest-controlling compound, an aspirin and vegetarian diet common catabolite, and a component of many traditional liquors and herbal remedies, was singled out as a powerful inhibitor of fibroblast growth factors. Gentisic acid was used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it was shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis. In addition, we obtained evidence from in vivo disease models that this group of inhibitors may be of interest to treat cancer and angiogenesis-dependent diseases.The fibroblast growth factors (FGFs) 4 constitute one of the largest families of polypeptide growth factors. There are 22FGFs in humans and mice that differ significantly in both size (17-20 kDa) and sequence, although each contains a core homology region encompassing 120 -130 residues. Phylogenetic analyses suggest that the FGF genes can be arranged into seven subfamilies. All FGFs bind to heparin with high affinity (K d between 1-2 nM), except for the members of the FGF-19 subfamily (i.e.: FGF-15, -19, -21, and -23) that have little or no affinity for these glycosaminoglycans (1). Apart from the family comprising FGF-11 to FGF-14, FGFs exert their diverse biological actions by binding to a series of membrane tyrosine kinase receptors (FGFRs) that are encoded by four genes (2-4). For this reason the FGF family is currently considered to be constituted by 18 members.FGFs were first isolated in the 1980s from bovine brain extracts due to their mitogenic and angiogenic activities (5). The affinity of FGFs for heparin was recognized very soon after their discovery (6), although the physiological substrate for FGF in normal conditions is heparan sulfate, a proteoglycan whose glycoside moiety is a glycosaminoglycan like heparin. Although initially conceived as FGF traps and protectors, it was later shown that these proteoglycans also participate in FGF signaling, although they are not absolutely required (4,7,8).In addition to the effects on cell replication and angiogenesis observed initially, FGFs r...

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confidence: 92%

Gentisic Acid, a Compound Associated with Plant Defense and a Metabolite of Aspirin, Heads a New Class of in Vivo Fibroblast Growth Factor Inhibitors

Fernandez

Cuevas

Angulo

et al. 2010

Journal of Biological Chemistry

106

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“…Boham et al [13] had reported that the increase of 'phenolics' is related to higher resistance in Brassica plant. It had documented that the amount of free p-coumaric acid in grains was related to the degree of resistance level of infestation by Sesamia larval forms to growing maize plant [22]. It has been further documented that the development of S. oryzae on legumes, peas, lentils, green and black gram was related to the grain properties [23].…”

Section: Discussionmentioning

confidence: 99%

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2017

RJLBPCS

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with grain length, grain length to width ratio and 100-grain weight (P<0.01), but had no relationship with grain width and grain thickness. Grain carbohydrate, had shown significant positive relation with S.oryzae infestation while in case of lipid, flavonoid and phenol content, the relation is significantly negative. In consideration of physico-chemistry of the rice grains proper storage procedure should be adopted.

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“…Allelopathic plant water extracts application at low concentration improved the performance of maize which might be attributed to the presence of various secondary metabolite including phenolics such as indole-3-acetic acid (IAA) (Casimiro et al, 2001), vanillic acid, phydroxybenzoic acid, p hydroxybenzaldehyde, p-coumaric acid, ferulic acid (Sene et al, 2001), tannic acid (Santiago et al, 2005), and chlorogenic acid (Bushman et al, 2002) present in sorghum water extract (Cheema, 1988). Allelopathic crop water extracts delay the expression of senescence related genes, increase plant photosynthesis duration (Lim et al, 2007) and scavenge harmful effects of reactive oxygen species (ROS) (Rice-Evans et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Influence of Foliage Applied Allelopathic Water Extracts on the Grain Yield, Quality and Economic Returns of Hybrid Maize

Kamran¹,

Cheema²,

Farooq³

et al. 2016

IJAB

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To cite this paper: Kamran, M., Z.A. Cheema, M. Farooq and A.U. Hassan, 2016. Influence of foliage applied allelopathic water extracts on the grain yield, quality and economic returns of hybrid maize. AbstractAllelochemicals at low concentrations can promote the crop growth and productivity. In this study, allelopathic extracts of sorghum, maize, rice and moringa each at 3% were applied alone and in various combinations at 30 and 50 days after sowing (DAS) of maize crop. No spray and water spray were included as controls for comparison. Application of allelopathic extracts significantly improved plant height, number of grains and grain rows per cob, number of grains per row, 1000-grain weight, grain yield, protein, starch, oil and leaf chlorophyll contents of maize as compared to control during both the years of study. Maximum increase in grains per cob, grain rows per cob, 1000-grain weight, grain number and grain yield (35%) was noted by combined application of sorghum and moringa water extracts. Economic analysis revealed that combination of sorghum and moringa extracts was the most economical followed by combination of maize and moringa extracts and moringa extract alone. In conclusion, sorghum and moringa extract combination at 3% may be foliage applied for harvesting better maize yield of good quality with comparatively higher economic returns.

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Free Phenols in Maize Pith and Their Relationship with Resistance to <I>Sesamia nonagrioides</I> (Lepidoptera: Noctuidae) Attack

Cited by 41 publications

References 51 publications

Gentisic Acid, a Compound Associated with Plant Defense and a Metabolite of Aspirin, Heads a New Class of in Vivo Fibroblast Growth Factor Inhibitors

Gentisic Acid, a Compound Associated with Plant Defense and a Metabolite of Aspirin, Heads a New Class of in Vivo Fibroblast Growth Factor Inhibitors

Untitled

Influence of Foliage Applied Allelopathic Water Extracts on the Grain Yield, Quality and Economic Returns of Hybrid Maize

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