Free radical and antioxidant status in rheumatoid arthritis

Bhowmick, Kaushik; Chakraborti, Goutam; Gudi, NS; Moideen, AV Kutty; Shetty, H. V.

doi:10.1016/s0973-3698(10)60073-8

Cited by 12 publications

(11 citation statements)

References 20 publications

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“…It should be added that a similar increase in 254 SOD activity was found in the plasma of RA patients [33] and in the synovial 255 membrane of mice with collagen-induced arthritis [34]. 256 257 Interestingly, the changes in the enzymatic antioxidant systems produced by 258 adjuvant arthritis were totally prevented in the C5 group which was fed with a diet 259 containing 5% cocoa (P < 0.05; Fig.…”

Section: Introduction 47 48mentioning

confidence: 76%

Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis

Ramos-Romero

Pérez-Cano

Ramiro-Puig

et al. 2012

Pharmacological Research

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23 24Cocoa contains flavonoids with antioxidant properties. The aim of this study was to 25 ascertain the effect of cocoa intake on oxidative stress associated with a model of 26 chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5 or 27 10% cocoa-enriched diet or were given p.o. a quercetin suspension every other day for 28 10 days. Arthritis was induced by a heat-killed Mycobacterium butyricum suspension. 29Reactive oxygen species (ROS) produced by macrophages, and splenic superoxide 30 dismutase (total, cytoplasmic and mitochondrial) and catalase activities were 31 determined. Clinically, joint swelling in arthritic rats was not reduced by antioxidants; 32 however, the 5% cocoa diet and quercetin administration reduced ROS production. 33Moreover, the 5% cocoa diet normalized the activities of superoxide dismutase and 34 catalase. In conclusion, a cocoa diet reduces the oxidative stress associated with a 35 chronic inflammatory pathology, although it was not enough to attenuate joint swelling. 36 37

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Section: Introduction 47 48mentioning

confidence: 76%

Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis

Ramos-Romero

Pérez-Cano

Ramiro-Puig

et al. 2012

Pharmacological Research

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“…Several studies have clearly indicated the possibility that these changes observed in the oxidative stress parameters in RA patients may be considered to be an accurate reflection of the synovial and articular changes 32–35 . In a study conducted by Chaturvedi et al .…”

Section: Discussionmentioning

confidence: 99%

Status of oxidative stress in rheumatoid arthritis

Pallinti¹,

Ganesan²,

Gaddipati

2009

Int J of Rheum Dis

132

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Aim: To assess the oxidative stress status in rheumatoid arthritis by measuring markers of free radical production, systemic activity of disease, free radical mediated tissue destruction and levels of antioxidant. Methods:Peripheral blood samples were used for all the assays. Total nitric oxide (NO) was quantitatively measured using immunoassay kit. Malondialdehyde (MDA) and vitamin E were measured by spectrophotometric methods.Results: Statistically significant changes were observed in the levels of MDA, vitamin E, total NO and erythrocyte sedimentation rate (ESR) in the patient group. Significant differences were also observed in ESR and vitamin E levels in patients with active disease. Conclusions:Increased oxidative stress status exists, which may lead to connective tissue degradation leading to joint and periarticular deformities in rheumatoid arthritis.

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“…It is basically termed as a systemic, chronic, autoimmune progressive disorder causing inflammation in synovial membrane resulting in the damage of cartilage and subchondral bone associated with consistent pain and inflammation [3]. Several studies have reported the involvement of oxidative stress due to the generation of free radicals as a major underlying mechanism for the progression of rheumatoid arthritis (RA) [4,5]. It has been found that, during the process of inflammation in RA, various pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) are released and deemed as vital markers for the RA progression [6,7].…”

Section: Introductionmentioning

confidence: 99%

Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB

Sun

Wei²,

Bi³

2017

Pharmacology

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The present study was intended to elucidate the effect of rutin, a flavonoid, on arthritis in complete Freund's adjuvant-induced arthritic rats. The present study showed that more pronounced effect has been observed in the case of 15 mg/kg dose of rutin, with significant reduction in paw diameter together with positive modulation of hematological parameters as compared to 2 other tested doses. A significant upsurge in the level of superoxide dismutase, glutathione peroxidase and glutathione were observed together with decrease in the level of malondialdehyde after treatment with rutin in a dose-dependent manner. Furthermore, the effect of rutin on the tumor necrosis factor-α and interleukin-1β in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-κB p65 and NF-κBp65 (Ser536) has been significantly reduced in the presence of rutin. Histopathological examination showed that the inflammatory cells infiltration, synovial hyperplasia, pannus formation and cartilage and bone erosion had considerably improved on administration of rutin. In conclusion, our paper strongly demonstrated the protective effect of rutin against the rheumatoid arthritis involved via suppression of NF-κB p65 protein expression.

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Free radical and antioxidant status in rheumatoid arthritis

Cited by 12 publications

References 20 publications

Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis

Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis

Status of oxidative stress in rheumatoid arthritis

Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB

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Free radical and antioxidant status in rheumatoid arthritis

Cited by 12 publications

References 20 publications

Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis

Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis

Status of oxidative stress in rheumatoid arthritis

Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-&#x03BA;B

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Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB