Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae)

Luhata, Lokadi Pierre; Usuki, Toyonobu

doi:10.1016/j.bmcl.2022.128528

Cited by 20 publications

(11 citation statements)

References 26 publications

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“…Another study shows that AC exhibits a high activity in DPPH radical scavenging with an IC 50 value of 0.09 μg/mL. In addition, AC shows more potent in scavenging H 2 O 2 with an IC 50 value of 2.6 μg/mL than ascorbic acid (IC 50 = 4.0 μg/mL) [55] . The anti-oxidative activity can be divided two groups, including the direct and the indirect anti-oxidative activity.…”

Section: Anti-oxidative Stressmentioning

confidence: 97%

The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao¹,

Ren²,

Wu³

2022

Biomedicine & Pharmacotherapy

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Section: Anti-oxidative Stressmentioning

confidence: 97%

The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao¹,

Ren²,

Wu³

2022

Biomedicine & Pharmacotherapy

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“…The EtOAc fraction (E1-3, 3210 mg) was subjected to RP-HPLC, and 6 fractions were collected (A-F) . Verbascoside and isoversbascoside were previously isolated and identified from fractions A and B 20) . Fractions C to F, named E1-3A, E1-3B, E1-3C and E1-3D, were submitted for spectroscopic analysis (UV, IR, NMR, MS) .…”

Section: Resultsmentioning

confidence: 99%

<i>In vitro</i> DPPH Radical Scavenging Activity of α-Pyrones from <i>Odontonema strictum</i> (Acanthaceae)

et al. 2023

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An ethyl acetate leaf extract from Odontonema strictum has been reported to have potent antihypertensive activity by inhibiting coronary artery contractions in porcine heart. However, the phytochemistry of the active fraction was unknown. Here we report, for the first time, the isolation and characterization of four known α-pyrones from the active fraction. The antioxidant activity of umuravumbolide (IC 50 = 55.7±0.027 µg/mL), deacetylumuravumbolide (IC 50 = 0.24±0.0002 µg/mL), dideacetylboronolide (IC 50 = 149±0 µg/mL) and deacetylboronolide (IC 50 = 24±0 µg/mL) was evaluated in vitro against 2,2-diphenyl-1-picrylhydrazyl radicals. Ascorbic acid was used as a positive control (IC 50 = 1.73×10 -3 ±0.3 µg/mL). The presence of 6-substituted 5,6-dihydro-α-pyrones and phenylpropanoid glucosides in the active fraction was suggested to be responsible for the antihypertensive activity. This is the first time that the antioxidant potential of these phytochemicals has been evaluated, and the results indicate that O. strictum has potential as an herbal medicine. Thus, further chemotaxonomic studies among the genera Odontonema and Tetradenia, a known source of α-pyrones, are recommended.

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“…The presence of the o -dihydroxyphenyl group in their molecule has been shown to have a strong positive effect on antioxidant potential [ 52 , 53 ]. Several authors have demonstrated that these compounds showed great DPPH• scavenging ability as well as reducing power [ 54 , 55 , 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites

et al. 2023

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Some of the more than 350 Scutellaria species, such as S. baicalensis and S. lateriflora, have been used in traditional medicine and today play an important role in official phytotherapy. Other species have been less investigated, and their therapeutic potential is unknown. This is one of the few studies on Scutellaria brevibracteata subsp. subvelutina, and the first research of this species’ in vitro cultures. The aim of this study was to establish an in vitro culture and analyse its phytochemical profile and biological activity. In the methanolic extracts from biomass cultured on six solid Murashige and Skoog (MS) medium variants supplemented with different combinations of 6-benzylaminopurine (BAP) and 1-naphthaleneacetic acid (NAA) in the range 0.5–3 mg/L analysed by HPLC, the presence of specific flavonoids (baicalein, baicalin, wogonin, wogonoside, scutellarin, chrysin), phenylpropanoid glycosides (verbascoside, isoverbascoside), and phenolic acids (p-hydroxybenzoic, caffeic, ferulic, m-coumaric acids) was confirmed. The dominant metabolites were wogonoside and verbascoside with the highest content of 346 and 457 mg/100 g DW, respectively. Thus, the extract with the highest content of bioactive metabolites was selected for further research and subjected to evaluation of antioxidant and antimicrobial potential. The extract exhibited good free radical scavenging activity (IC50 = 0.92 ± 0.01 mg/mL) and moderate reducing power and chelating activity. The brine shrimp lethality bioassay proved its lack of biotoxicity. Antimicrobial activity was tested against sixteen strains of Gram-positive and Gram-negative bacteria and fungi. The strongest growth inhibitory activity was observed against Trichophyton tonsurans.

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Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae)

Cited by 20 publications

References 26 publications

The pharmacokinetic property and pharmacological activity of acteoside: A review

The pharmacokinetic property and pharmacological activity of acteoside: A review

<i>In vitro</i> DPPH Radical Scavenging Activity of α-Pyrones from <i>Odontonema strictum</i> (Acanthaceae)

In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites

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