Free radical scavenging activity of Cleome gynandra L. leaves on adjuvant induced arthritis in rats

Narendhirakannan, R. T.; Subramanian, S.; Kandaswamy, M.

doi:10.1007/s11010-005-3234-6

Cited by 38 publications

(25 citation statements)

References 36 publications

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“…Our previous studies indicates that extract of A. marmelos possess the polyphenol and flavonoids compounds that modulates the activity of enzymic and nonenzymic antioxidants and enhances the defense against ROS-generated damage in diabetic rats and Cleome gynandra leaf extract contains high content of glycosides and flavonoids and possess significant anti-arthritic activity as evidenced by mediated through its inhibiting effect on the formation of lipid peroxide and effective free radical scavenging activity [74,75].…”

Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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Skin is the largest body organ that serves as an important environmental interface providing a protective envelope that is crucial for homeostasis. On the other hand, it is a major target for toxic insult by a broad spectrum of physical and chemical agents that are capable of altering its structure and function. There are a large number of dietary contaminants and drugs can manifest their toxicity in skin. These environmental toxicants or their metabolites are inherent oxidants and/or directly or indirectly drive the production of a variety of reactive oxidants also known as reactive oxygen species. These are short-lived entities that are continuously generated at low levels during the course of normal aerobic metabolism. These are believed to activate proliferative and cell survival signaling that can alter apoptotic pathways that may be involved in the pathogenesis of a number of skin disorders. The skin possesses an array of antioxidant defense mechanisms that interact with toxicants to obviate their deleterious effect. The ''antioxidant power'' of a food is an expression of its capability both to defend the human organism from the action of the free radicals and to prevent degenerative disorders. Plants like olive trees have their own built-in protection against the oxidative damage of the sun, and these built-in protectors function as cell protectors in our own body. Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive.

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Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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“…The antinociceptive activity could be because of the flavonoid-mediated peripheral mechanism. Most of the NSAIDs have all around adjusted mitigating and ulcerogenic exercises, which are thought to be because of prostaglandins synthetase inhibitor activity [32][33][34].…”

Section: As An Anti-inflammatory Agentmentioning

confidence: 99%

“…Glutathione peroxidase activities; reduced glutathione and superoxide dismutase activity were also decreased significantly. The free radical scavenging capacity of C. gynandra leaf extract was additionally confirm by histological examination [16,32,35].…”

Section: As a Free Radical Scavenging Agentmentioning

confidence: 99%

Medicinally Important Plant Cleome Gynandra: A Phytochemical and Pharmacological Explanation

Adhikari¹,

Paul

2018

Asian J Pharm Clin Res

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Cleome genus includes 601 plant species from the family Cleomaceae. Of more than 600 plants, 206 (34.3%) plants are having accepted species names. Cleome gynandra Linn. is a well-known medicinal plant with traditional and pharmacological importance. A good number of secondary plant metabolites have also been isolated from different parts of C. gynandra. Our investigation confirms two mutant varieties of C. gynandra exists in India. Accordingly, the objective of this study was designed to critically evaluate the pharmacological and phytochemical evaluation of C. gynandra of two mutant variety, to provide a consolidated platform for research potential of both the mutant varieties of C. gynandra. Careful scrutiny reveals that the plant possesses a huge range pharmacological applications, such as anti-inflammatory, free radical scavenging, anticancerous, immunomodulator, and antidiabetic agents. To arrive its pharmacological importance the published papers also shown an enormous amount of phytochemicals endorsement. Scientific perusal reveals different parts of the plant has an immense medicinal importance which proofs its traditional use round the glove. But in North-Eastern region of India, the same plant abundantly found in pink mutant variety. To date, there is not much research investigation for this mutant variety to validate its pharmacological importance. Therefore, research needs to scrutinize and compare the medicinal claims of the pink mutant variety in the bio-diverse region of North-East India.

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“…Free radicals such as Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions 6 and can react with and damage complex cellular molecules such as fats, proteins, or DNA 7 . In low/moderate concentrations free radicals are involved in normal physiological functions but excess production of free radicals or decrease in antioxidant level leads to oxidative stress 8 .…”

Section: Issn: 0975-8232mentioning

confidence: 99%

Untitled

2011

IJPSR

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Phytochemical constituents present in the aqueous and ethanolic extract of Syzygium cumini seeds were investigated which were found to be responsible for its medicinal efficacy. The major phytoconstituents present in S. cumini seeds were further determined by GCMS analysis which showed the presence of polyphenols, sesquiterpenes, n-alkanes. The antibacterial activity of ethanolic extract of S. cumini seeds were tested against common human pathogens by agar well diffusion method and minimum inhibitory concentration required to inhibit the growth of various pathogens were also evaluated. The seed extract was found to have high antibacterial activity. The total polyphenolic content of the ethanolic extract of S. cumini seed was determined by Folin-Ciocalteau method. The antioxidant activity of S. cumini seed ethanolic extract was evaluated by DPPH free radical scavenging assay, reducing power assay and total antioxidant capacity. S. cumini seed extract was found to have very high and potent antioxidant activity and might be due to the presence of high phenolic components in seed. The cytotoxicity assay of S. cumini seed ethanolic extract was carried out by trypan blue dye exclusion technique where the seed extract showed potential cytotoxic activity against cervical cancer cells.

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Free radical scavenging activity of Cleome gynandra L. leaves on adjuvant induced arthritis in rats

Cited by 38 publications

References 36 publications

Oxidative Stress and Skin Cancer: An Overview

Oxidative Stress and Skin Cancer: An Overview

Medicinally Important Plant Cleome Gynandra: A Phytochemical and Pharmacological Explanation

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