Free radical scavenging activity of methanolic extract of marine red algae Actinotrichia fragilis

Baskaran, K.; Rathi, Muthaiyan Ahalliya; Nirmaladevi, N.

doi:10.31024/ajpp.2019.5.5.3

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The findings of the present investigation are similar to those observed by Alghazeer et al [16], who reported that C. tomentosum extracts possess antioxidant and antiproliferative activities which might be helpful in preventing or slowing the progress of various oxidative stress-related disorders. The findings of the present investigation are similar to those observed by Baskaran et al [59], who reported that methanol crude extracts of A. fragilis contain different potential antioxidant compounds able to scavenge different types of free radicals. Acanthophora specifera flavonoid separation reveals a combination of chlorogenic acid (69.64%), caffeic acid (12.86%), vitexin-rahmnose (12.35%), quercetin (1.41%) and catechol (0.59%) [60].…”

Section: Antioxidant Activitysupporting

confidence: 92%

Fillet Fish Fortified with Algal Extracts of Codium tomentosum and Actinotrichia fragilis, as a Potential Antibacterial and Antioxidant Food Supplement

et al. 2022

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With respect to the potential natural resources in the marine environment, marine macroalgae or seaweeds are recognized to have health impacts. Two marine algae that are found in the Red Sea, Codium tomentosum (Green algae) and Actinotrichia fragilis (Red algae), were collected. Antibacterial and antioxidant activities of aqueous extracts of these algae were evaluated in vitro. Polyphenols from the extracts were determined using HPLC. Fillet fish was fortified with these algal extracts in an attempt to improve its nutritional value, and sensory evaluation was performed. The antibacterial effect of C. tomentosum extract was found to be superior to that of A. fragilis extract. Total phenolic contents of C. tomentosum and A. fragilis aqueous extract were 32.28 ± 1.63 mg/g and 19.96 ± 1.28 mg/g, respectively, while total flavonoid contents were 4.54 ± 1.48 mg/g and 3.86 ± 1.02 mg/g, respectively. Extract of C. tomentosum demonstrates the highest antioxidant activity, with an IC50 value of 75.32 ± 0.07 μg/mL. The IC50 of L-ascorbic acid as a positive control was 22.71 ± 0.03 μg/mL. The IC50 values for inhibiting proliferation on normal PBMC cells were 33.7 ± 1.02 µg/mL and 51.0 ± 1.14 µg/mL for C. tomentosum and A. fragilis, respectively. The results indicated that both algal aqueous extracts were safe, with low toxicity to normal cells. Interestingly, fillet fish fortified with C. tomentosum extract demonstrated the greatest overall acceptance score. These findings highlight the potential of these seaweed species for cultivation as a sustainable and safe source of therapeutic compounds for treating human and fish diseases, as well as effective food supplements and preservatives instead of chemical ones after performing in vivo assays.

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Section: Antioxidant Activitysupporting

confidence: 92%

Fillet Fish Fortified with Algal Extracts of Codium tomentosum and Actinotrichia fragilis, as a Potential Antibacterial and Antioxidant Food Supplement

et al. 2022

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“…DPPH has a deep purple colour. Antioxidant compounds cause fading of this colour by scavenging free DPPH radical and transforming it into a 2,2-diphenyl 1-hydrazine, a colourless compound which results in decrease in absorbance [ [72] , [73] , [74] ]. The ability of extracts of aerial parts of Ajuga bracteosa to scavenge DPPH free radical was found to be concentration dependent and highest for methanolic extract as compared to aqueous extract.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of paracetamol-induced hepatotoxicity in Ajuga bracteosa extract treated mice

Ali,

Jan,

Bashir

et al. 2024

Heliyon

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“…Valoniopsis panchynema studies as an anti-inflammatory agent are particularly gaining interest for the treatment of acute and chronic inflammation (20,21) . Marine sulfated polysaccharides, polyphenols and triterpenoids, have anti-coagulant, anti-inflammatory, anti-viral, and anti-tumor properties are essential in the pharmaceutical industry (22) . Researchers have extensively researched these bioactive components for their anti-inflammatory potential.…”

Section: Discussionmentioning

confidence: 99%

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

Bhuvaneshwari,

Chitra,

Vidya

et al. 2023

IJST

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Objectives: To validate the pharmacokinetic effects of the bioactive constituents present in green marine algae Valoniopsis pachynema for treating Psoriasis by in silco methods. Methods: The green marine macroalga was collected from the coastal areas of Ramanathapuram, Tamil Nadu and it was confirmed as Valoniopsis pachynema by the CSIR-Central Marine Algal Research Station, Ramanathapuram. The GC-MS analysis of the algal extract revealed the presence of 7 different functional compounds and these ligands molecules were used for molecular docking studies with TNF-α, which is majorly involved in causing Psoriasis. The ADME Predictions of 7 compounds were computed by SwissADME and PreADMET tools. The physico-chemical properties and druglikeness predictions of the compounds 1-7 were analysed by Molinspiration. The Molecular Docking scores and the residual amino acid interactions of 7 compounds against crystal structure of TNF-α (2AZ5) binding domain were analysed by Autodock Vina. Findings : The potential functional compounds present in the algal extract were found to be Cycloartenol (CAL), Eicosane (ESN), Phytol (PTL), Cis-13 Eicosenoic acid (CEA), Octadecanoic acid (ODA), Squalene (SQL) and Neophytadiene (NPN). The pharmacokinetic properties and docking studies of all 7 different ligands revealed Cycloartenol as the effective ligand having inhibitor constant 3.05µM and binding energy of -7.52 kcal/mol against TNF-α and it was found to interact with the amino acids ILE 136 and PRO 139 present in the active site domain of the protein. According to the in silico studies, the active component (Cycloartenol (CAL) in Valoniopsis pachynema reduces the amount of tumour necrosis factor which is produced in chronic skin inflammation. Thus, the seaweed metabolites were found to be the promising candidates https://www.indjst.org/ 4339

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Free radical scavenging activity of methanolic extract of marine red algae Actinotrichia fragilis

Cited by 5 publications

References 9 publications

Fillet Fish Fortified with Algal Extracts of Codium tomentosum and Actinotrichia fragilis, as a Potential Antibacterial and Antioxidant Food Supplement

Fillet Fish Fortified with Algal Extracts of Codium tomentosum and Actinotrichia fragilis, as a Potential Antibacterial and Antioxidant Food Supplement

Attenuation of paracetamol-induced hepatotoxicity in Ajuga bracteosa extract treated mice

In-Silico and Pharmacokinetic Studies of Bioactive Constituents from Green Marine Macro Algae Valoniopsis pachynema Against Psoriasis

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