Free Radical Scavenging Activity of Some Nigerian Medicinal Plant Extracts

Sofidiya, Margaret O.; Odukoya, Onatolu; Familoni, Oluwole B.; ., S.I. Inya-Agha

doi:10.3923/pjbs.2006.1438.1441

Cited by 46 publications

(14 citation statements)

References 10 publications

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“…It is usually grown in West Africa and Southern Nigeria [32]. Moderate antioxidant property and free radical scavenging activity for this plant was reported by Oke and Hamburger [33] and Sofidiya et al [34]. The amount of total phenolic compounds was also reported as 5 mg g -1 gallic acid equivalent which was considerably higher than total phenolic compounds detected in the present study.…”

Section: Discussioncontrasting

confidence: 45%

Evaluation of Antibacterial Activity and Phenolic Contents of Four Nigerian Medicinal Plants

Çağri‐Mehmetoğlu¹

2017

Int. J. Food Processing Techno.

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In this study, phenolic compounds and antimicrobial properties of four medicinal plants from Nigeria was investigated. The antibacterial properties and minimum inhibition concentration of Microdesmis puberula, Hypoestis verticillaris, Icacina tricantha, and Enterolobium cyclocarpum against 21 different bacteria was carried out using the disc diffusion assay. These plant extract were subjected to phytochemical screening by reverse phase HPLC (high pressure liquid chromatography) coupled with diode array detection and GC-MS (gas chromatography-mass spectrum). H. verticillaris had the most significant activity and showed inhibitory activity against most of the Gram-positive bacteria. However, M. puberula was only effective against the growth of Staphylococcus aureus and Enterobacter sakkai with inhibition zone of 8 mm. Furthermore, both I. tricantha and E. cyclocarpum only had antimicrobial effect on S. warneri with the inhibition zone of 12 and 13 mm, respectively. The results showed that M. puberula mostly contained 0.46 mg100 g-1 dry sample quarcetin and H. verticillaris contained approximately 0.7 mg 100 g-1 dry sample mangiferin and quarcetin. Moreover, both I. tricantha and E. cyclocarpum contain mostly quarcetin and rutin. According to GC-MS results, M. puberula contained thymol and methyl cinnamic acid and H. verticillaris contained methyl cinnamic acid and gallic acid. These plant extracts can be considered to be used in the cosmetic and food industries or even as a safe alternative to synthetic antimicrobial drugs.

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Section: Discussioncontrasting

confidence: 45%

Evaluation of Antibacterial Activity and Phenolic Contents of Four Nigerian Medicinal Plants

Çağri‐Mehmetoğlu¹

2017

Int. J. Food Processing Techno.

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“…The antioxidant capacity of phenolic compounds is mainly attributed to their redox properties, allowing them to act as reducing agents, electron donors, oxygen quenchers, or metal chelators (Sofidiya et al, 2006;Sylvie et al, 2014). In a study carried by Ghasemzadeh et al (2015), the authors claimed that among the three different locations in Malaysia (Kelantan, Pahang, and Johor) E. elatior in the northeastern region (Kelantan) exhibited potent anticancer against the tumour cell lines MCF-7 and MDA-MB-231.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, antiproliferative and antioxidant attributes of ethanolic extract of resinous sediment from Etlingera elatior (Jack.) inflorescence

Al-Mansoub

Asif

Revadigar

et al. 2021

Braz. J. Pharm. Sci.

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The ethanolic extract of resinous sediment (EERS) of Etlingera elatior young inflorescence was examined for its anticancer effect and potential antioxidant activity. The anticancer effect of the EERS was evaluated on four human cancer cell lines, HCT 116, HT-29, Hela, and MCF-7, using the MTT assay. GC-MS analysis showed that the main components found in the EERS were nonyl cyclopropane (4.44%), 1-tetradecane (3.66%), cyclotetradecane (2.41%), cyclododecane (1.92%), and 1-decene (1.72%). The antioxidant activity was determined through different methods. High amounts of TPC and TFC in the EERS were found. Moderate antioxidant capacity of the EERS was detected by DPPH and ABTS assays, with EC 50 values of 44.19 and 56.61 μg/mL and a high FRAP value of 281.79 nmol Fe +2 equivalent/mg extract. In the MTT assay, the EERS showed potent anticancer activity, with IC 50 values of 19.82, 37.001, 50.49, and 53.29 μg/mL against HT-29, HCT 116, Hela, and MCF-7 tumour cell lines, respectively. Moreover, the results were comparable to or less potent than the standard reference drug, 5-fluorouracil. The results showed that the EERS of Etlingera elatior inflorescence contained a high amount of polyphenols and flavonoids, which may to the selective antiproliferative effects towards colon cancer in vitro.

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“…; Article no.EJMP.16429 integrity and shrinkage of nuclei in the induced group, the treated groups showed restoration to the normal histomorphology of the animals. Many of the metabolites from medicinal plants like especially flavonoids exhibited in vitro and in vivo [18,19,20]. The activities of these antioxidants improve cell .…”

Section: Average Weight At Sacrifice(grams)mentioning

confidence: 99%

Histo-morphological Effects of Carica papaya on Cadmium Induced Prefrontal-Cortex Damage in Adult Wistar Rats

Akpan

Omotoso

Ogbonna

et al. 2018

EJMP

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Background: This research investigated the recuperative (restorative) effect of aqueous extract of Carica papaya fruit on cadmium induced prefrontal-cortex damaged in adult Wistar rats (Rattus norvegicus). Previous research reports have confirmed that cadmium toxicity results in cellular damage which is due to an increase in production of reactive oxygen species and prevention of the activities of antioxidant enzymes. Various parts of the brain (prefrontal cortex, hippocampus and so on) are majorly affected by cadmium as its induced damage. Methods: 30 Wistar rats (70 g-190 g) were used for this research. The rats were randomly selected into six groups of five animals each. A single dose of 3CdSO 4 .8H 2 O (Cadmium sulphate octahydrous) 3.5 mg/kg body weights was administered intraperitoneally to three of these groups against control a group that was not exposed to Cadmium. Two groups were treated with different doses of Carica papaya fruit extract for the period of four weeks. After four weeks, the rats were sacrificed and organs excised, weigh and fixed in fixative for histological processing. The photomicrographs of the normal control, induced control and treated groups were observed and compared for histomorphological similarities and differences. Results: Cadmium was observed to have caused a distortion, disruption and calcification in the cells and tissue of the prefrontal cortex. There was shrinkage of nuclei of the neurons in cadmium induced rats. It was also observed that cadmium caused a loss in function of cell in the process of protein biosynthesis. The morphology of the neuronal cells of rats treated with high and low doses of Carica papaya extract was found to be slightly normal with increased viable neuronal cells as compared with the neurons of the normal control group 1 animals, though the restorative effects of the high dose treated rats were more pronounced. Also, it was observed that the damage to the brain section neurons treated with vitamins C and E before induction was not pronounced. Moreso, loss in body weight were observed in cadmium induced group animals and over treatment with Carica papaya, gain in the rats body weight was observed in the treatment animal groups as compared with the body weight of rats in normal control. Animal body weight before cadmium inoculation, after inoculation and before animal sacrifice were compared across all the groups and it was found that, there was a progressive increase in rats body weight (99±2,35≤ 150 ±3.21), (120±2.32≤189±3.21) and (135±1.35≤175±2.15) respectively which was significant at P ≤ 0.05. Conclusion:It can be ascertained from this present study that Carica papaya has ameliorative properties against deleterious effects of cadmium on the neurons and neuroglia of the prefrontalcortex in Wistar rats which is dose dependent.

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Free Radical Scavenging Activity of Some Nigerian Medicinal Plant Extracts

Cited by 46 publications

References 10 publications

Evaluation of Antibacterial Activity and Phenolic Contents of Four Nigerian Medicinal Plants

Evaluation of Antibacterial Activity and Phenolic Contents of Four Nigerian Medicinal Plants

Chemical composition, antiproliferative and antioxidant attributes of ethanolic extract of resinous sediment from Etlingera elatior (Jack.) inflorescence

Histo-morphological Effects of Carica papaya on Cadmium Induced Prefrontal-Cortex Damage in Adult Wistar Rats

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