Free radical-scavenging activity of indolic compounds in aqueous and ethanolic media

Caño, Antonio; Alcaraz, Olga; Arnao, Marino B.

doi:10.1007/s00216-003-1848-7

Cited by 78 publications

(60 citation statements)

References 30 publications

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“…Animals can obtain IAA from intestinal absorption of a diet rich in vegetables or from synthesis from tryptophan in various tissues. 6 Studies have showed that IAA can provide antioxidant activity by inhibiting lipid peroxidation similarly to other indolic compounds 7,8 and provide semen preservation at similar concentrations 9 in water coconut 10 ; in addition, IAA have a topic antiinflammatory action. 11 Recent studies have shown that oral or subcutaneous administration of IAA can promote a possible beneficial effect by increasing the phagocytic capacity of rat neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Protective action of indole‐3‐acetic acid on induced hepatocarcinoma in mice

Mourão

Cruz

Paulo

et al. 2008

Cell Biochemistry & Function

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In this study, we report the protective effects of IAA on diethylnitrosamine (DEN)-induced hepatocarcinogenesis. BALB/c mice received daily IAA at 50 (T 50 ), 250 (T 250 ), and 500 (T 500 ) mg Kg À1 per body mass by gavage for 15 days. At day 15, animals were administered DEN and sacrificed 4 h later. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed in sera. In addition, hepatomorphologic alterations, activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), gene expression of antioxidant enzymes and DNA integrity were evaluated in the liver. IAA administration did not show any alterations in any of the parameters available, except for a reduction of the gene expression for antioxidant enzymes by 55, 56, 27, and 28% for SOD, CAT, GPx, and GR upon T 500 , respectively compared with the control. Several hepatic alterations were observed by DEN exposure. Moreover, IAA administration at 3 doses was shown to provide a total prevention of the active reduction of CAT and GR induced by DEN exposure compared with the control. IAA at T 500 was shown to give partial protection (87, 71, 57, and 90% for respectively SOD, CAT, GPx, and GR) on the down-regulation of the enzymes induced by DEN and this auxin showed a partial protection (50%) on DEN-induced DNA fragmentation for both parameters when compared to DEN alone. This work showed IAA hepatocarcinogenesis protection for the first time by means of a DEN-protective effect on CAT and GR activity, and by affecting antioxidant gene expression and DNA fragmentation.

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Section: Introductionmentioning

confidence: 99%

Protective action of indole‐3‐acetic acid on induced hepatocarcinoma in mice

Mourão

Cruz

Paulo

et al. 2008

Cell Biochemistry & Function

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“…It has been reported that GOA was synthesized from indole-3-acetic acid, which is known to be a plant hormone and also an antioxidant, 26) through HOA in the kernels of supersweet corn after seed germination. GOA and HOA have been suggested to be inactive metabolites of indole-3-acetic acid; 25) however, the antioxidative effects of these substances were demonstrated here and may protect seeds against oxidative stress, rather than simply being inactive metabolites of indole-3-acetic acid.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative Activities of Oxindole-3-acetic Acid Derivatives from Supersweet Corn Powder

Midoh

Tanaka

Nagayasu

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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The components contributing to the antioxidative activity of supersweet corn powder (SSCP), which is commonly used in corn soup and snacks in Japan, were clarified and the effects investigated. 7-(O--Glucosyloxy)oxindole-3-acetic acid (GOA) was found to be the component most strongly contributing to the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity of the 80% ethanol extract of SSCP, and the presence of its aglycone, 7-hydroxy-oxindole-3-acetic acid (HOA) was confirmed. GOA and HOA respectively contributed 35.1% and 10.5% to the DPPH radicalscavenging activity of the 80% ethanol extract of SSCP. Mice orally administered with HOA at doses of both 500 and 1500 mg/kg showed a significantly lower (p < 0:05) level of thiobarbituric acid reactive substances (TBARS) in the plasma than the vehicle-treated control. These results suggest that GOA and HOA were at least partly involved in the antioxidative activity of SSCP in vitro and that HOA might have possessed antioxidative activity in vivo.

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“…In recent years, many physiological properties of MLT have been described resulting in much attention in the development of synthetic compounds possessing the indole ring. Synthetic indole derivatives such as indole-3-propionic acid 7 , indole amine-triazoles 8 , and stobadine 9 have shown significant antioxidant activity. Our group identified the antioxidant activity of MLT analogue indole derivatives such as 2-phenylindoles 10 , indole-3-propionamides 11 , 5-bromoindole hydrazide/hydrazones derivatives 12 , and N-methylindole hydrazide/hydrazones 13 .…”

Section: Introductionmentioning

confidence: 99%