Free radical scavenging and cytoprotective activities of phenolic antioxidants

Zhang, Jingli; Stanley, Roger; Adaim, Aselle; Melton, Laurence D.; Skinner, Margot A.

doi:10.1002/mnfr.200600072

Cited by 75 publications

(54 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They also confirm previous observations in vitro on wine polyphenols' inhibitory activity on CRP levels [17]. Extra-virgin olive oil, in particular, and fruits, vegetables, wine, and fish are important components of a Mediterranean diet that is rich in polyphenols and simple phenols [18,3,4,5,6]. In this study, we have decided to maintain the usual ad libitum intake of olive oil, but the same extra-virgin olive oil was used for all participants of the study.…”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Anti-Inflammatory Effect of White Wine in CKD Patients and Healthy Volunteers

et al. 2015

View full text Add to dashboard Cite

Background: Mediterranean-style diet has been considered for its important beneficial effects on the progression of CV disease. Wine is an important component of the Mediterranean diet, and moderate wine drinkers have lower mortality rates than nondrinkers and heavy drinkers in epidemiologic studies. The beneficial effects of red wine are thought to be dependent on the polyphenol compounds such as resveratrol that exhibit potent antioxidant activity. However, white wine, although lacking polyphenols, contains simple phenols, such as tyrosol (Tyr) and hydroxytyrosol (OH-Tyr), characteristic also of extra-virgin olive oil, which may share similar antioxidant and inflammatory properties. Patients and Methods: The effect of white wine and extra-virgin olive oil on inflammatory markers was evaluated in 10 healthy volunteers and in 10 patients with CKD (chronic kidney disease) K-DOQI stage III-IV in a prospective, single blind, randomized, cross-over trial. After two weeks of wash-out from alcoholic beverages, subjects were randomized to a cross-over design A-B or B-A of a 2-week treatment with white wine (4 ml/kg body weight, 0.48 g/kg of alcohol 12%, corresponding to 2-3 glasses/daily) and extra-virgin olive oil (treatment A) or extra-virgin olive oil alone (treatment B). The two study periods were separated by a two-week wash-out period. At baseline and at the end of each treatment, plasma levels of inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8) concentration were determined. Urinary levels of Tyr, OH-Tyr, and their metabolites were measured at the same time. Results: During combined consumption of white wine and extra-virgin olive oil (treatment A), plasma levels of CRP and IL-6 decreased from 4.1 ± 1.8 to 2.4 ± 1.9 mg/l (p < 0.05) and from 5.3 ± 3.2 to 3.4 ± 2.3 mg/l (p < 0.05) in CKD patients. CRP decreased from 2.6 ± 1.2 to 1.9 ± 0.9 mg/l (p < 0.05), and IL-6 decreased from 2.2 ± 1.8 to 1.7 ± 1.3 mg/l (p = ns) in healthy volunteers. No significant variation versus baseline was observed during treatment B. A significant increase in urinary Tyr and OH-Tyr was observed during treatment A (white wine and extra-virgin olive oil). Conclusions: Plasma markers of chronic inflammation were significantly reduced in CKD patients during the combined consumption of white wine and olive oil, suggesting a possible anti-inflammatory effect of this nutritional intervention.

show abstract

Section: Discussionsupporting

confidence: 76%

“…These foods are rich in compounds, known for their antioxidant activity [5]. For example, a fundamental role is played by polyphenols and simple phenols, present in vegetables, wine, and olive oil [6].…”

Section: Background and Aim Of The Studymentioning

confidence: 99%

Anti-Inflammatory Effect of White Wine in CKD Patients and Healthy Volunteers

et al. 2015

View full text Add to dashboard Cite

show abstract

“…HCAs have been shown to be phytochemicals with remarkable antioxidant outlines they are able; a) to increase the resistance of low density lipoprotein (LDL) to lipid peroxidation [56,79,80]; b) to protect proteins against oxida-tion [81]; c) to chelate transition metals that catalyze oxida-tive reactions [82]; d) to scavenge a variety of ROS [47,[83][84][85][86]; e) to inhibit enzymes that are involved in oxidative stress [48,87].…”

Section: Coo Hmentioning

confidence: 99%

Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships

Razzaghi‐Asl¹,

Garrido²,

Khazraei³

et al. 2013

CMC

172

View full text Add to dashboard Cite

Hydroxycinnamic acids (HCAs) are important phytochemicals possessing significant biological properties. Several investigators have studied in vitro antioxidant activity of HCAs in detail. In this review, we have gathered the studies focused on the structure-activity relationships (SARs) of these compounds that have used medicinal chemistry to generate more potent antioxidant molecules. Most of the reports indicated that the presence of an unsaturated bond on the side chain of HCAs is vital to their activity. The structural features that were reported to be of importance to the antioxi-dant activity were categorized as follows: modifications of the aromatic ring, which include alterations in the number and position of hydroxy groups and insertion of electron donating or withdrawing moieties as well as modifications of the car-boxylic function that include esterification and amidation process. Furthermore, reports that have addressed the influence of physicochemical properties including redox potential, lipid solubility and dissociation constant on the antioxidant activ-ity were also summarized. Finally, the pro-oxidant effect of HCAs in some test systems was addressed. Most of the investigations concluded that the presence of ortho-dihydroxy phenyl group (catechol moiety) is of significant importance to the antioxidant activity, while, the presence of three hydroxy groups does not necessarily improve the activity. Optimiza-tion of the structure of molecular leads is an important task of modern medicinal chemistry and its accomplishment relies on the careful assessment of SARs. SAR studies on HCAs can identify the most successful antioxidants that could be use-ful for management of oxidative stress-related diseases.Keywords: Antioxidant, hydroxycinnamic acids, in vitro, ROS, structure-activity relationships. OXIDATIVE STRESS AND ANTIOXIDANTSReactive oxygen species (ROS) are oxygen derived molecules that readily react with other compounds and macromolecules and oxidize them. Some representative exam-ples of these species include superoxide (O2•-), hydroxy (HO • ) and peroxy (ROO • ) radicals, hydrogen peroxide (H2O2) and singletROS are involved in important physiological processes such as immune response, gene expression, signal transduc-tion and growth regulation [5,6]; however if they are not kept under tight control by physiological antioxidant systems they will be able to oxidize and damage various biological molecules leading to a condition called oxidative stress [1,7,8]. In this regard, oxidative stress has been reported to be in-volved in the pathogenesis of diseases such as cancer [9], neurodegenerative diseases [10], stroke [11], and others [12,13].Since an important source of ROS comes from environment [14], with the industrial development and the change in life style, oxidative stress related diseases need a special attention [15].Antioxidants operate by preventing or slowing the progression of oxidative damage reactions [16,17]. An antioxidant has been defined as "any substance that delays, p...

show abstract

“…However, their studies were focused on ferulic acid related compounds, its alkyl esters and gallic acid esters. Zhang et al (2006) compared the free radical scavenging activity of hydroxycinnamic acids namely caffeic, ferulic and sinapic acid. But they employed the oxygen radical absorbance capacity (ORAC) and lipid peroxide inhibition capacity (LPIC) assays.…”

Section: Introductionmentioning

confidence: 99%

Reactivity of phenolic compounds towards free radicals under in vitro conditions

2015

View full text Add to dashboard Cite

The free radical scavenging activity and reducing power of 16 phenolic compounds including four hydroxycinnamic acid derivatives namely ferulic acid, caffeic acid, sinapic acid and p-coumaric acid, benzoic acid and its derivatives namely protocatechuic acid, gallic acid and vanillic acid, benzene derivatives namely vanillin, vanillyl alcohol, veratryl alcohol, veratraldehyde, pyrogallol, guaiacol and two synthetic antioxidants, butylated hydroxy anisole (BHA) and propyl gallate were evaluated using 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH • ), 2,2′-Azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS +• ), Hydroxyl radical ( • OH) and Superoxide radical (O 2•-

show abstract

Free radical scavenging and cytoprotective activities of phenolic antioxidants

Cited by 75 publications

References 50 publications

Anti-Inflammatory Effect of White Wine in CKD Patients and Healthy Volunteers

Anti-Inflammatory Effect of White Wine in CKD Patients and Healthy Volunteers

Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships

Reactivity of phenolic compounds towards free radicals under in vitro conditions

Contact Info

Product

Resources

About