Free radical scavenging and tyrosinase inhibition activity of oils and sericin extracted from Thai native silkworms (<i>Bombyx mori</i>)

Manosroi, Aranya; Boonpisuttinant, Korawinwich; Winitchai, Supanida; Manosroi, Worapaka; Manosroi, Jiradej

doi:10.3109/13880200903300212

Cited by 51 publications

(38 citation statements)

References 10 publications

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“…All sericin samples showed tyrosinase inhibiting activity with IC 50 values in the range of 1.2-18.76 mg/mL, but only oils from Noneruesee extracted using the hot process, and Nangleung, Somrong, and Noneruesee extracted using the cold process, demonstrated this activity. Oil extracted using the hot process and sericin by basic hydrolysis from Noneruesee yieded the highest antityrosinase activity, but lower than that of the standards vitamin C and kojic acid by 20-49 and 3-8 times, respectively [33].…”

Section: Antioxidant Activitymentioning

confidence: 95%

“…Silkworm has been reported with free radical scavenging and tyrosinase inhibitory activities, as well as superoxide dismutase activity. For example, Manosroi et al conducted an experiment on five Thai native silkworms (Keawsakol, Nangnoi, Somrong, Nangleung, and Noneruesee) and extracted bioactive components (such as oils and sericin) and tested their antioxidant activity [33]. The oils were extracted by a hot process using Soxhlet apparatus and a cold process using petroleum ether, while sericin was extracted by basic hydrolysis and autoclaving.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Bioactive Constituents of the Silk Worm Bombyx mori

Xia

Fang

et al. 2013

Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds

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Silkworm is economically important and also has a large number of activities encompassing anticancer, antibacterial, antibacterial, antiviral, antihypertensive, angiotensin-converting enzyme activity, hepatoprotective, superoxide dismutase enzyme activity, free radical scavenging and tyrosinase inhibitory, antidiabetic, antityrosinase, cognition enhancing, alternative complement pathwayinhibiting, carotenoid binding, chymotrypsin inhibiting, and chitinase activities. These activities may be beneficial to human health.

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Section: Antioxidant Activitymentioning

confidence: 95%

Section: Antioxidant Activitymentioning

confidence: 99%

Bioactive Constituents of the Silk Worm Bombyx mori

Xia

Fang

et al. 2013

Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds

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“…2 Mulberry silkworm (B. mori) has been reared for longtime in many regions of Thailand especially the Northeast. 3 Reports on the various pharmacological activities of the silkworm have been accumulated such as antioxidant, 4 anticancer, 5 antibacterial, 6 antiviral, 7 antihypertensive, 8 and hepatoprotective activities. 9 Type 2 diabetes is a chronic disease with the mechanisms potentially linked to overweight and obesity.…”

Section: Introductionmentioning

confidence: 99%

“…The difference of races was provided different pharmacological capacities. 4 Fibroin and sericin from silkworm were generally used as medical biomaterial.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic Effect of Silkworm Powder, Fibroin and Sericin from Three Thai Silkworm (Bombyx mori Linn.) in Streptozotocin-Induced Diabetic Rats

Rattana¹,

Katisart²,

Butiman³

et al. 2017

Phcog J

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“…Among such natural compounds, a silkworm protein derived from domesticated Bombyx mori has been used effectively in biological research, including an ingredient in cosmetics [7]- [10]. Specifically, silk proteins have well-known bioactive characteristics and functions, such as anti-oxidation, UV-resistance, biocompatibility, biodegradability, inhibitory tyrosine activity, and others [11].…”

mentioning

confidence: 99%

Whitening Effect of Storage Protein 2 from Silkworm Hemolymph

Kim¹,

Hwang²,

Lee³

et al. 2014

ABB

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This study investigated the effects of silkworm hemolymph-derived storage protein 2 (SP2) on the whitening process in mouse B16F1 melanoma cells. After the cells were treated with various concentrations of SP2 (0.1 -1.0 mg/mL), cytotoxicity, melanin contents, and differences in mRNA and protein expression associated with melanogenesis were observed. No cytotoxicity was observed when cells were treated with SP2, even with increased SP2 concentrations of up to 2.0 mg/mL. When treated with various SP2 concentrations in the cells, the protein and mRNA expression of tyrosinase were dose-dependently decreased, respectively, and inhibition of tyrosinase was further increased by 50.0% with increasing SP2 concentration of 1.0 mg/mL. Expression mRNAs coding tyrosinase related protein-1 and protein-2 (TRP-1 and TRP-2) was also significantly decreased in a dose dependent manner. When measuring the melanin content in melanoma cells, SP2 at 1 mg/mL inhibited melanin synthesis by 73.5% compared with non-treated cells. The inhibitory effect was 2.8-fold higher than that obtained using arbutin as a positive control. This study demonstrates that SP2, as a whitening material, is capable of suppressing melanin synthesis through the downregulation of proteins and genes in the melanin biosynthesis pathway.

show abstract

Free radical scavenging and tyrosinase inhibition activity of oils and sericin extracted from Thai native silkworms (Bombyx mori)

Cited by 51 publications

References 10 publications

Bioactive Constituents of the Silk Worm Bombyx mori

Bioactive Constituents of the Silk Worm Bombyx mori

Antihyperglycemic Effect of Silkworm Powder, Fibroin and Sericin from Three Thai Silkworm (Bombyx mori Linn.) in Streptozotocin-Induced Diabetic Rats

Whitening Effect of Storage Protein 2 from Silkworm Hemolymph

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