Free radical-scavenging, antioxidant and immunostimulating effects of a licorice infusion (Glycyrrhiza glabra L.)

Cheel, José; Antwerpen, Pierre Van; Tůmová, Lenka; Onofre, Gabriela; Vokurková, Doris; Zouaoui-Boudjeltia, Karim; Vanhaeverbeek, Michel; Nève, Jean

doi:10.1016/j.foodchem.2010.02.060

Cited by 65 publications

(53 citation statements)

References 32 publications

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“…As the binding of free radical metabolites to cellular macromolecules was considered to be one of the mechanism of CCl 4 -mediated toxicity, the reported free-radical-scavenging activities of licorice infusion (Cheel et al 2010) and glycyrrhiza flavonoids (Okuda et al 1989) would certainly play an important role in the protective action of Glycyrrhiza glabra extract against hepatotoxicity. Another possibility could be that Glycyrrhiza glabra extract affected the binding conditions of the free radical metabolites to cellular macromolecules.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio)

Yin

Cao

et al. 2010

Fish Physiol Biochem

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The present study is aiming at evaluating the hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract (2.5, 5 and 10 μg/ml) on the carbon tetrachloride (CCl(4))-induced carp hepatocyte damage in vitro. Glycyrrhiza glabra extract was added to the carp primary hepatocytes before (pre-treatment), after (post-treatment) and both before and after (pre- and post-treatment) the incubation of the hepatocytes with CCl(4). CCl(4) at 8 mM in the culture medium produced significantly elevated levels of lactate dehydrogenase (LDH), glutamate oxalate transaminase (GOT), glutamate pyruvate transaminase (GPT) and malondialdehyde (MDA) and significantly reduced levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Pre-treatment (5 μg/ml) and pre- and post-treatment (5 and 10 μg/ml) of the hepatocytes with Glycyrrhiza glabra extract significantly reduced the elevated levels of LDH, GOT, GPT and MDA and increased the reduced levels of SOD and GSH-Px by CCl(4); post-treatment of the hepatocytes with Glycyrrhiza glabra extract at 5 μg/ml reduced the GPT and GOT levels and increased the GSH-Px level, but had no effect on the other parameters at all the studied concentrations. The results support the use of Glycyrrhiza glabra extract as a hepatoprotective and antioxidant agent in fish.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio)

Yin

Cao

et al. 2010

Fish Physiol Biochem

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“…[15][16][17][18] Its antioxidant properties have also been reported, either in aqueous, 7,19,20 ethanol, [20][21][22] methanol 20,[23][24][25] or methanol/water 26,27 extracts. There are several studies that focused on the phenolic characterization of Glycyrrhiza sp.…”

Section: -14mentioning

confidence: 99%

Characterization of phenolic compounds and antioxidant properties of Glycyrrhiza glabra L. rhizomes and roots

et al. 2015

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The present work aims to characterize and quantify the phenolic composition and to evaluate the antioxidant activity of Glycyrrhiza glabra L. (commonly known as licorice) rhizomes and roots. The antioxidant potential of its methanol/water extract could be related to flavones (mainly apigenin derivatives), flavanones (mainly liquiritin derivatives), a methylated isoflavone and a chalcone, identified in the extract. Lipid peroxidation inhibition was the most pronounced antioxidant effect (EC 50 ). In this sense, licorice extract could be used as a source of antioxidants for the pharmaceutical, cosmetic and/or food industries.

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“…Liquorice has been shown to exert numerous beneficial effects, such as anti-inflammation (Cho et al, 2010), hypocholesterolaemic and antioxidant effects (Cheel et al, 2010;Visavadiya & Narasimhacharya, 2006). In addition, GZ has been recognised to be responsible for the bioactivities of anti-inflammation (Yuan et al, 2006), anti-virus (Harada, 2005) and hepatitis improvement (Orlent et al, 2006;Sato et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A

2012

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Free radical-scavenging, antioxidant and immunostimulating effects of a licorice infusion (Glycyrrhiza glabra L.)

Cited by 65 publications

References 32 publications

Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio)

Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio)

Characterization of phenolic compounds and antioxidant properties of Glycyrrhiza glabra L. rhizomes and roots

Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A

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