Free Radical Scavenging Behavior of Antioxidant Compounds of Sesame (Sesamum indicum L.) in DPPH^• System

Abstract

The free radical scavenging capacity (RSC) of antioxidants from sesame cake extract was studied using the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(*)()) on a kinetic model. Pure lignans and lignan glycosides isolated from methanolic extract by preparative HPLC were used in the study. To understand the kinetic behavior better and to determine the RSC of sesame antioxidants, the second-order rate constant (k(2)) was calculated for the quenching reaction with [DPPH(*)] radical. The k(2) values of the sesame antioxidants were compared with those of butylated hydroxytoluene and alpha-tocopherol. The k(2) values for sesamol, sesamol dimer, sesamin, sesamolin, sesaminol triglucoside, and sesaminol diglucoside were 4.00 x 10(-)(5), 0.50 x 10(-)(5), 0.36 x 10(-)(5), 0.13 x 10(-)(5), 0.33 x 10(-)(5), and 0.08 x 10(-)(5) microM(-)(1) s(-)(1), respectively.

Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

“…Accumulating evidence suggests that the protective effects of SO against oxidative damage could be attributed to its antioxidative properties [9,11,24] . The antioxidant activity of SO could be attributed to its phenolic lignans-type compounds namely sesamol, sesamin and sesaminol [6] . These antioxidant compounds have been found to possess antioxidant effects against oxidative damage induced by cupper in vitro study [10] and endotoxin lipopolysaccharide [8,24] and ischemiareperfusion [12] in rats.…”

“…These include p-coumaric acid [4] , garlic acid [2] , erdosteine [5] and carvedilol [1] . Sesame Oil (SO) is extract from the plant Sesamum indicum (HS), family: Pedaliaceae [6] . SO offers protection over blood pressure, lipid profiles and lipid peroxidation in hypertensive patients [7] .…”

Sesame oil enhances endogenous antioxidants in ischemic myocardium of rat

“…Much research evidence suggests that the protective role of sesame oil against oxidative stress through its antioxidant mechanism (Kaur & Saini, 2000;Nakano et al, 2002;Hsu & Liu, 2004). It has been identified that presence of antioxidative principles like sesamin, sesamol and sesaminol might be a responsible components for its protective action (Suja et al, 2004). Therefore, the protection against myocardial IR injury in the treated rats is attributable to enhanced endogenous antioxidant activity.…”

Genetic Variability, Standardized Multiple Linear Regression and Principal Component Analysis to Determine Some Important Sesame Yield Components

“…Sesame is an important commodity supporting various industries and produce oil which is low in saturated fat (Suja, Jayalekshmy, & Arumughan, 2004). Sesame is normally self-pollinated species and a composite of various homozygous individuals in populations (Furat & Uzun, 2010).…”