Free radical scavenging is involved in the protective effect of l-propionyl-carnitine against ischemia-reperfusion injury of the heart

Packer, Lester; Valenza, M.; Serbinova, E. A.; Starke–Reed, Pamela; Frost, Kerry; Kagan, Valerian E.

doi:10.1016/0003-9861(91)90231-7

Cited by 113 publications

(50 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[75] However, a vitamin E-enriched diet was reported to increase GSH level and inhibit oxidative endothelial damage. [76] Regarding vitamin C, it functions as a cofactor for biosynthesis of carnitine, [77,78] and it exerts a protective role against the peroxidative damage through its lipid-lowering effect. [79] Carnitine itself has antioxidant action and a strong inhibitory effect on free radical production, [80,81] and it exerts thiol and methionine-sparing activity.…”

Section: Discussionmentioning

confidence: 99%

Multiple Antioxidants and L-Arginine Modulate Inflammation and Dyslipidemia in Chronic Renal Failure Rats

Korish

2010

Renal Failure

View full text Add to dashboard Cite

The kidney is an important source of L-arginine, the endogenous precursor of nitric oxide (NO). Surgical problems requiring extensive renal mass reduction (RMR) decrease renal NO production, leading to multiple hemodynamic and homeostatic disorders manifested by hypertension, oxidative stress, and increased inflammatory cytokines. Using the RMR model of chronic renal failure (CRF), we assessed the effects of twelve weeks' administration of L-arginine and/or a mixture of antioxidants (L-carnitine, catechin, vitamins E and C) on plasma cytokines, soluble intercellular adhesion molecule-1 (sICAM-1), nitrate and nitrites (NO 2 /NO 3 ), lipid profile, blood pressure, and renal function. CRF rats showed increased plasma IL-1a, IL1-b, IL-6, TNF-a, and sICAM-1 levels and decreased anti-inflammatory cytokines IL-4 and 10 levels, hypertension, and dyslipidemia. L-arginine treatment improved kidney functions, decreased systolic blood pressure, and decreased inflammatory cytokines levels. Antioxidants administration decreased inflammatory cytokines and sICAM-1 levels and increased IL-4 levels. Combined use of both L-arginine and the antioxidant mixture were very effective in their tendency to recover normal values of kidney functions, plasma cytokines, sICAM-1, blood pressure, NO 2 /NO 3 , cholesterol, and triglycerides concentrations. Indeed, the effects of L-arginine and the antioxidants on the reduction of proinflammatory cytokines may open new perspectives in the treatment of uremia.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple Antioxidants and L-Arginine Modulate Inflammation and Dyslipidemia in Chronic Renal Failure Rats

Korish

2010

Renal Failure

View full text Add to dashboard Cite

show abstract

“…Alternatively, elevated intracellular acetylcarnitine could serve as a substrate for aerobic metabolism which, when stimulated, inhibits anaerobic glycolysis by normal mechanisms of regulation. It has also been shown that the proprionyl esters of carnitine can inhibit free radical-mediated oxidative damage to proteins and lipids, 36 although it is not clear whether this is a direct effect of the drug or an indirect consequence of altered tissue energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine.

Rosenthal

Williams

Bogaert

et al. 1992

Stroke

134

View full text Add to dashboard Cite

Background and Purpose: Mechanisms of ischemia/reperfusion brain injury include altered patterns of energy metabolism that may be amenable to pharmacological manipulation. The purpose of this study was to test the effectiveness of postischemic acetyl-L-carnitine administration on potentiation of metabolic recovery and prevention of neurological morbidity in a clinically relevant model of complete, global cerebral ischemia and reperfusion.Methods: Neurological deficit scoring as well as spectrophotometric and fluorescent assays of frontal cortex lactate and pyruvate levels were used in a canine model employing 10 minutes of cardiac arrest followed by restoration of spontaneous circulation for 2 or 24 hours.Results: Dogs treated with acetyl-L-carnitine exhibited significantly lower neurological deficit scores (p=0.0037) and more normal cerebral cortex lactate/pyruvate ratios than did vehicle-treated control animals.Conclusions

show abstract

“…Furthermore, there is evidence that free radicals may be involved in the development of ascites (Bottje & Wideman, 1995). As L-carnitine (ester) is known to have free radical scavenging properties (Packer et al, 1991), this might also contribute to a beneficial effect of L-carnitine on ascites incidence. This hypothesis is currently under investigation (Buyse et al, 2001).…”

Section: Managing the Growth Ratementioning

confidence: 99%

Ascites syndrome in broilers: physiological and nutritional perspectives

2008

View full text Add to dashboard Cite

Broiler chickens are intensively selected for productive traits. The management of these highly productive animals must be optimal to allow their full genetic potential to be expressed. If this is not done, inefficient production and several metabolic diseases such as ascites become apparent. The causes of the ascites are multifactorial but diet and, particularly, interactions between diet, other environmental and genetic factors play an important role. The relatively high heritability estimates for ascites-related traits and the significance of maternal genetic effects for most of the traits indicate that direct and maternal genetic effects play an important role in development of the ascites syndrome. An imbalance between oxygen supply and the oxygen required to sustain rapid growth rates and high food efficiencies causes ascites in broiler chickens. Because of the relationship to oxygen demand, ascites is affected and/or precipitated by factors such as growth rate, altitude (hypoxia) and environmental temperature. As the high metabolic rate (fast growth) is a major factor contributing to the susceptibility of broilers to ascites, early-age feed or nutrient restriction (qualitative or quantitative) or light restriction in order to slow down the growth rate seem practically viable methods, since final body weight is not compromised. Manipulation of the diet composition and/or feed allocation system can have a major effect on the incidence of ascites. Optimization of the house temperature and ventilation in cold weather seem helpful practices to decrease ascites incidence.

show abstract

Free radical scavenging is involved in the protective effect of l-propionyl-carnitine against ischemia-reperfusion injury of the heart

Cited by 113 publications

References 29 publications

Multiple Antioxidants and L-Arginine Modulate Inflammation and Dyslipidemia in Chronic Renal Failure Rats

Multiple Antioxidants and L-Arginine Modulate Inflammation and Dyslipidemia in Chronic Renal Failure Rats

Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine.

Ascites syndrome in broilers: physiological and nutritional perspectives

Contact Info

Product

Resources

About