Free Radicals and Health: Indicators for a Unifying Concept

Boenig, Herman V.

doi:10.1111/j.1532-5415.1966.tb02922.x

Cited by 9 publications

(1 citation statement)

References 70 publications

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“…have long been implicated as causal factors in human illness (1,2). Although a number of enzymatic and nonenzymatic antioxidant defense mechanisms normally maintain an "uneasy truce" between oxidants and reductants, an imbalance can perturb homeostasis and result in disease.…”

Section: E Levated Concentrations Of Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Evidence of Oxidative Stress in Relation to Feeding Type During Early Life in Premature Infants

et al. 2011

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Morbidity in the premature (PT) infant may reflect difficult adaptation to oxygen. We hypothesized that feeding including formula feeding (F) and feeding mother's milk (HM) with added fortifier would affect redox status. Therefore, 65 PT infants (birth weight: 1146 Ϯ 261 g; GA: 29 Ϯ 2.5 wk; mean Ϯ SD) were followed biweekly, once oral feeds were introduced. Feeding groups: F (Ͼ75% total feeds) and HM (Ͼ75% total feeds) were further subdivided according to human milk fortifier (HMF) content of 0 -19, 20 -49, and Ն50%. Oxidative stress was quantified by F2-isoprostanes (F2-IsoPs) in urine, protein carbonyls, and oxygen radical absorbance capacity (ORAC) in plasma.

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Section: E Levated Concentrations Of Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Evidence of Oxidative Stress in Relation to Feeding Type During Early Life in Premature Infants

et al. 2011

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The effect of oxygen tension on the growth and metabolism of WI‐38 cells

Balin

Goodman

Rasmussen

et al. 1976

Journal Cellular Physiology

137

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The effect of oxygen tension on cellular growth and metabolism was studied in actively growing WI-38 cells [greater than 90% labeled nuclei (LN)] grown under atmospheres containing 5% CO2 and various combinations of O2 and N2. Cells grown under a partial pressure of oxygen (PO2) of 7.8 +/- 3.5 mm Hg had a significantly slower growth rate, lower saturation densities and higher rates of glucose consumption and lactate production than did cells grown under a PO2 of 44 +/- 7 mm Hg. There were no significant differences in saturation density or the rates of glucose consumption or lactate production between cells grown under PO2 26 +/- 4 mm Hg, 44 +/- 7 mm Hg, or 134 +/- 11 mm Hg. Population doubling time was slightly prolonged at a PO2 of 134 mm Hg compared to a PO2 of 44 mm Hg. Cells grown under a PO2 of 291 +/- 25 mm Hg showed only 20-30% of the growth rate and 10-20% of the saturation density of cells grown under a PO2 of 134 mm Hg. Despite this reduced growth, cells grown under a PO2 of 291 mm Hg consumed four to six times as much glucose and produced four to six times as much lactate per cell as cells grown at a PO2 of 134 mm Hg. Cells grown under a PO2 of 560 +/- 38 mm Hg attached but did not proliferate. This toxic effect of oxygen on cell proliferation was reversible and was not due to an effect of oxygen on the media.

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