Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings

Zykova, Yulia; Kudryavtseva, Valeriya; Gai, Meiyu; Kozelskaya, Anna; Frueh, Johannes; Sukhorukov, Gleb B.; Tverdokhlebov, Sergei I.

doi:10.1016/j.eurpolymj.2019.02.029

Cited by 24 publications

(27 citation statements)

References 62 publications

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“…Incorporation of ZnO in PLA matrix provide control over surface topography and Mg degradation rate. A free-standing PLLA micro-chamber array was developed by dip coat PLLA solution on PDMS stamp followed by drug loading and sealing with pre-coated polymer substrate, for drug delivery application [ 82 ]. A low frequency ultrasound trigger the release of drug and in vitro test revealed that the full cargo of drug was completely released in 13 days under physiological condition.…”

Section: Other Biopolymer Coatingsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Other Biopolymer Coatingsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…Rhodamine B was released within 13 days in a phosphate buffer solution. The PLA microchamber arrays can be applied as biodegradable drug depot system for the cover of implantable endovascular stent [ 223 ]. PLA/vancomycin-loaded noisome was designed through layer-by-layer nanocoating.…”

Section: Pla Applicationsmentioning

confidence: 99%

Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications

et al. 2021

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Environmental problems, such as global warming and plastic pollution have forced researchers to investigate alternatives for conventional plastics. Poly(lactic acid) (PLA), one of the well-known eco-friendly biodegradables and biobased polyesters, has been studied extensively and is considered to be a promising substitute to petroleum-based polymers. This review gives an inclusive overview of the current research of lactic acid and lactide dimer techniques along with the production of PLA from its monomers. Melt polycondensation as well as ring opening polymerization techniques are discussed, and the effect of various catalysts and polymerization conditions is thoroughly presented. Reaction mechanisms are also reviewed. However, due to the competitive decomposition reactions, in the most cases low or medium molecular weight (MW) of PLA, not exceeding 20,000–50,000 g/mol, are prepared. For this reason, additional procedures such as solid state polycondensation (SSP) and chain extension (CE) reaching MW ranging from 80,000 up to 250,000 g/mol are extensively investigated here. Lastly, numerous practical applications of PLA in various fields of industry, technical challenges and limitations of PLA use as well as its future perspectives are also reported in this review.

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“…An increasingly interesting approach to improving AISI 316LVM lies in its functionalization with coatings intended to prolong its lifespan [ 10 , 11 ], increase fast osteointegration [ 12 ], and/or provide improved long-term corrosion resistance [ 13 , 14 ]. Various materials have been employed for this purpose (e.g., selenium nanoparticles [ 15 ], hydroxyapatite in various forms [ 16 , 17 ], polylactic acid [ 18 ], peptide coatings [ 19 ], etc.). However, it seems that most of the interest lies in biocompatible coatings based on polysaccharides, such as alginate (ALG), carboxymethyl cellulose (CMC), and others [ 12 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone-Loaded Bioactive Coatings on Medical Grade Stainless Steel Promote Osteointegration

et al. 2021

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In this study, a multilayer bioactive coating based on carboxymethyl cellulose (CMC) and dexamethasone (DEX) was prepared on medical-grade stainless steel (AISI 316LVM). Its aim was the controlled drug delivery of the incorporated anti‑inflammatory drug, which at the same time promotes osteogenic differentiation of mesenchymal stem cells. Due to DEX’s limited solubility in physiological fluids, which limits the loading capacity of coatings, it was further combined with β-cyclodextrin to increase its concentration in the bioactive coating. Controlled release of DEX from the multilayer coating was achieved in four steps: a “burst”, i.e., very fast, release step (in an immersion interval of 0–10 min), a fast release step (10–30 min), a slow-release step (60–360 min), and a plateau step (360–4320 min), following a zero-order release or Higuchi model release mechanism. Successful layer-by-layer coating formation was confirmed using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). It was shown that the application of the coating significantly increases the hydrophilic character of AISI 316LVM, and also significantly increases the surface roughness, which is known to promote cell growth. In addition, electrochemical measurements demonstrated that the coating application does not increase the susceptibility of medical-grade stainless steel to corrosion. In vitro cell testing using all cell types with which such coatings come into contact in the body (osteoblasts, chondrocytes, and mesenchymal stem cells (MSCs)) showed very good biocompatibility towards all of the mentioned cells. It further confirmed that the coatings promoted MSCs osteogenic differentiation, which is the desired mode of action for orthopedic implants.

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Free-standing microchamber arrays as a biodegradable drug depot system for implant coatings

Cited by 24 publications

References 62 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications

Dexamethasone-Loaded Bioactive Coatings on Medical Grade Stainless Steel Promote Osteointegration

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