Free-standing multilayer films as growth factor reservoirs for future wound dressing applications

Hautmann, Adrian; Kedilaya, Devaki; Stojanović, Sanja; Radenković, Milena; Marx, Christian; Najman, Stevo; Pietzsch, Markus; Mano, João F.; Groth, Thomas

doi:10.1016/j.bioadv.2022.213166

Cited by 15 publications

(6 citation statements)

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“…In particular, the incorporation of the bone morphogenetic protein 2 (BMP-2) as an intrinsic LbL ingredient of [poly(baminoester)/chondroitin sulfate (CS)/BMP-2/CS] 100 multilayered films coated 3D printed scaffolds conducted to a very small burst release in the first few hours followed by a sustained linear release profile over a period of about 3 days, 91 corroborating the release profile of our (HTCC/ ALG/HTCC/FITC-BSA) 100 FS membranes. Besides, other studies have reported the production of either (CHT/ALG) 200 or (CHT/ALG) 100 FS multilayered membranes post-loaded with BMP-2 or FGF-2, 23,92 showcasing an initial burst release followed by a sustained and prolonged release along time until a plateau was reached, similar to the release kinetics observed for the (HTCC/ALG) 200 /HTCC/FITC-BSA FS membranes.…”

Section: Fitc-bsa Loading Capacity and In Vitro Release Profilesupporting

confidence: 66%

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery

et al. 2023

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Section: Fitc-bsa Loading Capacity and In Vitro Release Profilesupporting

confidence: 66%

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery

et al. 2023

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“…Self-healing is particularly valuable in applications where maintenance or repair may be challenging, such as in aerospace, automotive, biomedical, or structural materials. If successful, it will facilitate endless application opportunities for fabricating devices involving molecular machines, 133 multi-stimuli-responsiveness, 134 cell proliferation, 135 molecular recognition, 136 and others. Polymer interfacial extensive chain dynamics will facilitate longer range transport, which will have significant technological implications not only in self-healing, but also in adhesion, processing, welding, coalescence, and other dynamic processes.…”

Section: ■ Outlookmentioning

confidence: 99%

Dynamic Interfaces in Self-Healable Polymers

Liu,

Urban

2024

Langmuir

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It is well-established that interfaces play critical roles in biological and synthetic processes. Aside from significant practical applications, the most accessible and measurable quantity is interfacial tension, which represents a measure of the energy required to create or rejoin two surfaces. Owing to the fact that interfacial processes are critical in polymeric materials, this review outlines recent advances in dynamic interfacial processes involving physics and chemistry targeting self-healing. Entropic interfacial energies stored during damage participate in the recovery, and self-healing depends upon copolymer composition and monomer sequence, monomer molar ratios, molecular weight, and polymer dispersity. These properties ultimately impact chain flexibility, shape-memory recovery, and interfacial interactions. Self-healing is a localized process with global implications on mechanical and other properties. Selected examples driven by interfacial flow and shape memory effects are discussed in the context of covalent and supramolecular rebonding targeting self-healable materials development.

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“…It was found that the membranes with high cross-linking degree showcased enhanced mechanical properties and better cell adhesion and proliferation when compared with the membranes with low cross-linking degree or even the native ones ( Figure 15 ). Such cross-linked membranes also showed to be suitable reservoirs of biomolecules, including growth factors holding great potential for being used as wound dressing devices [ 255 ].…”

Section: Chitosan-based Layer-by-layer Assemblies For Biomedical Appl...mentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.

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Free-standing multilayer films as growth factor reservoirs for future wound dressing applications

Cited by 15 publications

References 62 publications

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery

Dynamic Interfaces in Self-Healable Polymers

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

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