Free versus total serum 25-hydroxyvitamin D in a murine model of colitis

Abstract

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The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

“…Thus, the interaction between DBP and 25-OH-D may play a key role in gastrointestinal responses to vitamin D. For example, mice raised on diets containing exclusively vitamin D2 showed much lower serum levels of 25-OH-D compared to mice raised on vitamin D3 only. However, because 25-OH-D2 binds with lower affinity to DBP than 25-OH-D3, the levels of free 25-OH-D were similar in the two groups of mice and both showed similar patterns of experimentally induced colitis [74]. These observations suggest that free 25-OH-D may be a more sensitive marker of the protective effects of vitamin D on IBD.…”