Freeze-dried whole plasma: Evaluating sucrose, trehalose, sorbitol, mannitol and glycine as stabilizers

Bakaltcheva, Irina; O’Sullivan, Anne Marie; Hmel, Peter J.; Ogbu, Helen

doi:10.1016/j.thromres.2006.07.005

Cited by 46 publications

(36 citation statements)

References 18 publications

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“…In concordance with previous observation, we found an increased prothrombin time and activated partial thromboplastin time in the same proportions. 25 This was in relation to a significant decrease in the activity of FVIII and FV. However, all parameters met the quality requirements of French regulations for plasma 26 and were within the physiologic ranges for coagulation factors (FIX, FXI, FXIII, fibrinogen, antithrombin, protein C and S, ␣ 2 antiplasmin).…”

Section: Critical Care Medicinementioning

confidence: 92%

In Vitro Hemostatic Properties of French Lyophilized Plasma

Martinaud¹,

Civadier

Ausset³

et al. 2012

Anesthesiology

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Background: French lyophilized plasma (FLyP) is used routinely by the French Armed Forces in war settings. The authors compared concentrations of coagulation proteins and global in vitro hemostatic properties in FLyP and in the same plasma before lyophilization to assess the impact of lyophilization on coagulation properties. Methods: Twenty-four batches of plasma before and after lyophilization were tested for coagulation proteins. Thrombin generation time, thrombin antithrombin concentration, prothrombin fragment 1 ϩ 2, and thromboelastography were assessed. Finally, the efficiencies of FLyP and plasma before lyophilization were compared on a hemorrhagic shock hemodilution model and tested on TEG

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Section: Critical Care Medicinementioning

confidence: 92%

In Vitro Hemostatic Properties of French Lyophilized Plasma

Martinaud¹,

Civadier

Ausset³

et al. 2012

Anesthesiology

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“…In contrast to FFP and SD plasma, lyophilised (freeze-dried) plasma can be stored at between 2 and 25°C, and reconstitution for transfusion usually requires less time than thawing frozen plasma 4. Lyophilised plasma is rarely used in clinical practice; it was introduced during World War II by the US Army,7 but its production in the USA was stopped because of the recognition at that time of the near-universal risk of pathogen transmission by pooled plasma products 8. A pathogen-inactivated, lyophilised plasma preparation has been approved for clinical use in Germany.…”

Section: Introductionmentioning

confidence: 99%

Lyophilised plasma: evaluation of clotting factor activity over 6 days after reconstitution for transfusion

et al. 2010

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“…It is classified as non hygroscopic (Kibbe, 2000). The use of mannitol as a protein stabilizer in dried protein formulations has been widely reviewed (Bakaltcheva et al, 2007;Schule et al, 2007;Torrado and Torrado, 2002).…”

Section: Introductionmentioning

confidence: 99%