Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair

Doiphode, Nikhil D.; Huang, Tieshu; Leu, Ming C.; Rahaman, Mohamed N.; Day, Delbert E.

doi:10.1007/s10856-011-4236-4

Cited by 91 publications

(46 citation statements)

References 35 publications

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“…SiC grid structures made by robocasting. [186] Fabrication/Freeze-Form Extrusion Fabrication (FEF), [125][126][127] Direct Ink Writing (DIW), [120] Slurry Deposition, [128] Dispense Plotting, [129] Bioplotting, [130] Rapid Prototyping Robotic Dispensing (RPRD), Microextrusion Freeforming (MF), Multiphase Jet Solidification (MJS), [131] 3D Fiber Deposition (3DFD), [132] and Robocasting (RC). [133] These synonyms exhibit mostly minor deviations regarding the process details.…”

Section: D Extrusion Freeforming Of Ceramics (Eff)mentioning

confidence: 99%

“…[135,144,146,150] Then a polymeric viscosifier/binder is added to prevent sedimentation and solvent migration, to ensure consistent extrusion and to provide green strength. After complete dissolution of the viscosifier, the suspension can be degassed by vacuum [125] or centrifugation [139,140] and then filled into the cartridge. If a colloidal gel is to be applied to EFF to offer improved shape retention for extrusion of free spanning filaments, tubes or special filament geometries, the slurry can be coagulated using several mechanisms (Van-derWaals forces, bridging flocculation and depletion flocculation) by adding salts, pH-modifiers or polymers.…”

Section: Feedstock Preparation and Propertiesmentioning

confidence: 99%

“…They include filters, laboratory equipment, catalysts, and catalyst carriers (Robocasting Enterprises LLC). Extrusion freeformed parts may find usage as solid ceramic prototypes, [137] photonic bandgap structures, [119,[167][168][169] piezoactuators, [145] microbatteries, [170] graded structures, [160] biomaterials, [125,144,147,154,155,164,[171][172][173][174][175][176][177][178][179][180][181][182] as well as military and aerospace applications, such as radomes and missile propulsion nozzles. [160] …”

Section: Present and Future Applicationsmentioning

confidence: 99%

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Additive Manufacturing of Ceramic‐Based Materials

et al. 2014

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This paper offers a review of present achievements in the field of processing of ceramic-based materials with complex geometry using the main additive manufacturing (AM) technologies. In AM, the geometrical design of a desired ceramic-based component is combined with the materials design. In this way, the fabrication times and the product costs of ceramic-based parts with required properties can be substantially reduced. However, dimensional accuracy and surface finish still remain crucial features in today's AM due to the layer-by-layer formation of the parts. In spite of the fact that significant progress has been made in the development of feedstock materials, the most difficult limitations for AM technologies are the restrictions set by material selection for each AM method and aspects considering the inner architectural design of the manufactured parts. Hence, any future progress in the field of AM should be based on the improvement of the existing technologies or, alternatively, the development of new approaches with an emphasis on parts allowing the near-net formation of ceramic structures, while optimizing the design of new materials and of the part architecture.

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Section: D Extrusion Freeforming Of Ceramics (Eff)mentioning

confidence: 99%

Section: Feedstock Preparation and Propertiesmentioning

confidence: 99%

Section: Present and Future Applicationsmentioning

confidence: 99%

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Additive Manufacturing of Ceramic‐Based Materials

et al. 2014

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“…Porous bioactive glass scaffolds can be fabricated with inter-connected pores and compressive strengths that match porous bone 5,6,7 , but they are too brittle for sites that are subjected to cyclic loading 5,8,9 . Inorganic-organic hybrids are of great interest because their molecular level interaction between the two components can provide synergistic properties while acting as a single phase material 10,11,12,13 .…”

Section: Introductionmentioning

confidence: 99%

Tailoring Mechanical Properties of Sol–Gel Hybrids for Bone Regeneration through Polymer Structure

Chung

Stevens

et al. 2016

Chem. Mater.

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Bioglass® was the first synthetic biomaterial that formed a chemical bond to bone. Although bioactive glass scaffolds can mimic bone's porous structure, they are brittle. Sol-gel derived hybrids could overcome this problem because their nanoscale co-networks of silica and organic polymer have the potential to provide unique physical properties and controlled homogenous biodegradation. Copolymers of methyl methacrylate (MMA) and 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) has been used as an organic source for hybrids to take advantage of its self-hardening property. However, the effect of well-defined poly(MMA-co-TMSPMA) architecture in the hybrid system has not been investigated. Here, linear, randomly branched and star shaped methacrylate based copolymers were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization method. These copolymers were then used to fabricate hybrids. The 3-D polymer structure had a significant effect on mechanical properties, providing higher strain to failure while maintaining a compressive strength similar to sol-gel glass. Star copolymer-SiO2 hybrids had a modulus of toughness 9.6 fold greater, and Young's modulus 4.5 fold lower than a sol-gel derived bioactive glass. During in vitro cell culture, MC3T3-E1 osteoblast precursor cells adhered on the surface regardless of the polymer structure. Introducing star polymers to inorganic-organic hybrids opens up possibilities for the fine-tuning physical properties of bone scaffold materials.

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“…Bioactive glass (13-93 or S53P4) scaffolds created with a grid-like microstructure (porosity ∼ 50%; pore width ∼ 300 µm) by additive manufacturing (3D printing) techniques have shown even higher compressive strength, comparable to human cortical bone (100-150 MPa) [20][21][22][23][24][25]. These scaffolds were shown to have a microstructure conducive to infiltration with new bone [26,27], elicited no adverse biological reaction over a long-term period in vivo (6 months) [26,28], and healed critical-size segmental defects in small and large rodents [29,30].…”

Section: Introductionmentioning

confidence: 99%

Review - bioactive glass implants for potential application in structural bone repair

Rahaman¹,

Xiao²,

Huang³

2017

Biomedical Glasses

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Bioactive glass particles and weak scaffolds have been used to heal small contained bone defects but an unmet challenge is the development of bioactive glass implants with the requisite mechanical reliability and in vivo performance to heal structural bone defects. Inadequate mechanical strength and a brittle mechanical response have been key concerns in the use of bioactive glass scaffolds in structural bone repair. Recent research has shown the capacity to create strong porous bioactive glass scaffolds and the ability of these scaffolds to heal segmental bone defects in small and large rodents at a rate comparable to autogenous bone grafts. Loading these strong porous scaffolds with bone morphogenetic protein-2 can significantly enhance their ability to regenerate bone. Recent work has also shown that coating the external surface of strong porous scaffolds with an adherent biodegradable polymer can dramatically improve their load-bearing capacity in flexural loading and their work of fracture (a measure of toughness). These tough and strong bioactive glass-polymer composites with an internal architecture conducive to bone infiltration could provide optimal synthetic implants for structural bone repair. Keywords:Bioactive glass for structural bone repair; bioactive glass composites; mechanical and in vivo evaluation of bioactive glass scaffolds

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Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair

Cited by 91 publications

References 35 publications

Additive Manufacturing of Ceramic‐Based Materials

Additive Manufacturing of Ceramic‐Based Materials

Tailoring Mechanical Properties of Sol–Gel Hybrids for Bone Regeneration through Polymer Structure

Review - bioactive glass implants for potential application in structural bone repair

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